Optimization of approaches to the management of adult patients with severe atopic dermatitis: analysis of real clinical practice outcomes

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Abstract

Atopic dermatitis (AD) is a multifactorial genetically determined immune-mediated skin disease. It is difficult to treat and significantly affects patients’ quality of life. The development of an integrated approach focusing on atopic multimorbidity, implementation of validated control tools and distinction of clinical parameters specific for different phenotypes of severe forms of disease is especially relevant to patients resistant to standard therapy techniques. Dupilumab, a biologic, is approved for the treatment of the resistant group of patients with moderate to severe AD in the Russian Federation. Dupilumab inhibits the functions of two key cytokines of T2-mediated inflammation – IL-4 and IL-13. The article presents personal experience of the authors concerning individual approach to the choice of therapy for the management of this cohort of patients in routine clinical practice. The disease aggravating criteria were determined, which are fundamental for the formation of individual patient portrait for the biologic (dupilumab) treatment for severe AD.

About the authors

Daria S. Fomina

City Clinical Hospital №52; Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: daria_fomina@mail.ru
ORCID iD: 0000-0002-5083-6637

Cand. Sci. (Med.)

Russian Federation, Moscow; Moscow

Sofya A. Serdotetskova

City Clinical Hospital №52

Email: darklynx813@gmail.com
ORCID iD: 0000-0001-8472-1152

allergist-immunologist

Russian Federation, Moscow

Anton A. Chernov

City Clinical Hospital №52; Russian Medical Academy of Continuous Professional Education

Email: sbornay1med@yandex.ru
ORCID iD: 0000-0001-6209-387X

therapist

Russian Federation, Moscow; Moscow

Marina S. Lebedkina

Sechenov First Moscow State Medical University (Sechenov University)

Email: marina.ivanova0808@yandex.ru
ORCID iD: 0000-0002-9545-4720

Clinical Resident

Russian Federation, Moscow

Asel Iu. Nurtazina

City Clinical Hospital №52; Sechenov First Moscow State Medical University (Sechenov University)

Email: asel26nurtazina@mail.ru
ORCID iD: 0000-0002-2337-3307

allergist-immunologist

Russian Federation, Moscow; Moscow

Mirada K. Gadzhieva

City Clinical Hospital №52

Email: mirada05@mail.ru
ORCID iD: 0000-0001-8899-0851

allergist-immunologist

Russian Federation, Moscow

Olga A. Mukhina

City Clinical Hospital №52

Email: mukhina.a.o@gmail.com
ORCID iD: 0000-0002-3794-4991

allergist-immunologist

Russian Federation, Moscow

Elena N. Bobrikova

City Clinical Hospital №52

Email: elena.bobrikova.69@mail.ru
ORCID iD: 0000-0002-6534-5902

Head of the Consultative and Diagnostic Department of the Center for Allergology and Immunology

Russian Federation, Moscow

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