Pathophysiologic aspects of resorption of intervertebral disk hernia

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Abstract

Spinal disc herniation is a pathological anatomical disorder that is associated with localized disk displacement beyond the intervertebral space. Although in most cases surgical intervention is not necessary for recovery, it still has an important role in this disorder treatment. In most patients a course of conservative treatment results in symptoms improvement and in some patients it allows to eliminate symptoms completely. Nevertheless the underlying mechanisms of this spontaneous improvement are still underexplored, though they may provide therapeutic potential that may speed up the recovery process and prevent development of long-term complications. The article considers in detail the origins of inflammatory response in spinal disc herniation development as well as interrelation between spinal disc herniation resorption and symptomatic improvement. Necessity for conduction of future research on the role of inflammatory response in spinal disc herniation formation and resorption is shown. It is important because understanding the reason why most of the patients recover without surgical intervention can speed up the recovery processes and allow many patients to avoid surgical treatment that will also result in improvement of quality of life in this group.

About the authors

Alexsander M. Tkachev

Dr.Berezin Medical Institute; Klinika Tkacheva

Email: tkachevclinic@gmail.com
neurologist Moscow, Russia

Anton V. Epifanov

Klinika Doktora Epifanova

Email: epifus@mail.ru
neurologist Moscow, Russia

Elena S. Akarachkova

International Society of Stress “Stress under Control”

Email: nevrorus@mail.ru
D. Sci. (Med.), Corr. Memb. RANS, president Moscow, Russia

Alina V. Smirnova

Dr.Berezin Medical Institute

Email: smirnova-av@ldc.ru
radiologis Moscow, Russia

Artem V. Iliushin

Dr.Berezin Medical Institute

radiologist Moscow, Russia

Daniil S. Archakov

Klinika Tkacheva

Email: danielsarch@yandex.ru
psychiatrist Moscow, Russia

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