Influence of preoperative oral carbohydrate loading on perioperative period (a pilot study)

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Abstract

Objective. To evaluate influence of preoperative oral carbohydrate loading on perioperative surgery results. Materials and methods. The prospective study included 51 patients in whom routine abdominal and retroperitoneal surgeries were performed. The patients were divided into 2 groups: study group and control group. In both groups surgeries were performed in identical conditions. In preoperative period control group (n=27) patients kept to a traditional protocol of preoperative fasting that meant consumption of solid food no later than 6 hours before the surgery and consumption of clear transparent liquids no later than 2 hours before the surgery. The patients in study group (n=24) consumed a carbohydrate drink before surgery (33.5 g of carbohydrates and 4 g of hydrolyzed protein in 100 ml): 400 ml in the evening before surgery and 200 ml 2 hours before surgery. Results. No differences in perioperative glycemia levels were observed, intraoperative infusion volume was lower, hemodynamic parameters were more stable, and the number of patients with organ dysfunction was significantly lower in the study group in comparison with control group. Conclusion. Preoperative carbohydrate loading resulted in decrease of infusion volume and more stable hemodynamic parameters in the intraoperative period as well as in decrease of organ dysfunction manifestations.

About the authors

Ivan A. Smeshnoi

Central State Medical Academy; Clinical Hospital

Email: iva2305@yandex.ru
Cand. Sci. (Med.)

Igor N. Pasechnik

Central State Medical Academy; Clinical Hospital

D. Sci. (Med.), Prof.

Denis A. Timashkov

Clinical Hospital

Email: denistima@gmail.com
anesthesiologist-intensivist

Mikhail A. Onegin

Clinical Hospital

Cand. Sci. (Med.)

Artem V. Cheparnov

Clinical Hospital

anesthesiologist-intensivist

References

  1. Rothman D, Magnusson I, Katz L.D et al. Quantification of hepatic glycogenolysis and gluconeogenesis in fasting humans with 13C NMR. Science 1991; 254 (5031): 573-6.
  2. Sunzel H. Effects of surgical trauma on the liver glycogen in fasting and in glucose-fed patients. Acta Chirurgica Scandinavica 1963; 125: 118-28.
  3. Nygren J. The metabolic effects of fasting and surgery. Best Pract Res Clin Anaesthesiol 2006; 20: 429-38.
  4. Пасечник И.Н., Назаренко А.Г., Губайдуллин Р.Р. и др. Современные подходы к ускоренному восстановлению после хирургических вмешательств. Доктор.ру. Анестезиология и реаниматология. Медицинская реабилитация. 2015; 15 (116), 16 (117): 10-7. @@Pasechnik I.N., Nazarenko A.G., Gubaidullin R.R. et al. Sovremennye podkhody k uskorennomu vosstanovleniiu posle khirurgicheskikh vmeshatel'stv. Doktor.ru. Anesteziologiia i reanimatologiia. Meditsinskaia reabilitatsiia. 2015; 15 (116), 16 (117): 10-7 (in Russian)
  5. Lee Q.Y, Liu H.M, Lim Y.L et al. Preoperative carbohydrate loading in diabetic patients within an enhanced recovery after surgery programme for colorectal surgery - Are there any ill effects? Clinical Nutrition ESPEN 2018; 25: 167.
  6. Read N.W, Houghton L.A. Physiology of gastric emptying and pathophysiology of gastroparesis. Gastroenterology Clinics North America 1989; 18 (2): 359-73.
  7. Tudor-Drobjewski B.A, Marhofer P, Kimberger O et al. Randomised controlled trial comparing preoperative carbohydrate loading with standard fasting in paediatric anaesthesia. Br J Anaesthesia 2018; 121 (3): 656-61.
  8. Li L, Wang Z, Ying X et al. Preoperative carbohydrate loading for elective surgery: a systematic review and meta-analysis. Surgery Today 2012; 42 (7): 613-24.
  9. Пасечник И.Н., Губайдуллин Р.Р., Борисов А.Ю. Основы нутритивной поддержки больных в критических состояниях. М.: РИА «Колизей», 2012.@@Pasechnik I.N., Gubaidullin R.R., Borisov A.Yu. Fundamentals of nutritional support for patients in critical conditions. Moscow: RIA "Colosseum", 2012 (in Russian).
  10. Van den Berghe G.H. Role of intravenous insulin therapy in critically ill patients. Endocr Pract 2004; 2: 17-20.
  11. Sato H, Carvalho G, Sato T et al. The association of preoperative glycemic control, intraoperative insulin sensitivity, and outcomes after cardiac surgery. J Clin Endocrinol Metab 2010; 95: 4338-44.
  12. Hausel J, Nygren J, Lagerkranser M et al. A carbohydrate-rich drink reduces preoperative discomfort in elective surgery patients. Anesth Analg 2001; 93: 1344-50.
  13. Hausel J, Nygren J, Thorell A et al. Randomized clinical trial of the effects of oral preoperative carbohydrates on postoperative nausea and vomiting after laparoscopic cholecystectomy. Br J Surg 2005; 92: 415-21.
  14. Singh B.N, Dahiya D, Bagaria D et al. Effects of preoperative carbohydrates drinks on immediate postoperative outcome after day care laparoscopic cholecystectomy. Surgical Endoscopy 2015; 29 (11): 3267-72.
  15. Adamova Z, Slováček R. Effects of preoperative carbohydrate drinks on postoperative outcome after colorectal surgery. Eur Surg 2017; 49 (4): 180-6.
  16. Weledji E.P, Njong S.N, Chichom A et al. The effects of preoperative carbohydrate loading on the metabolic response to surgery in a low resource setting. Int J Surg Open 2017; 8: 18-23.
  17. Смешной И.А., Пасечник И.Н., Скобелев Е.И. и др. Оптимизация инфузионной терапии в плановой абдоминальной хирургии. Общая реаниматология. 2018; 14 (5): 4-15. @@Smeshnoi I.A., Pasechnik I.N., Skobelev E.I. et al. Optimizatsiia infuzionnoi terapii v planovoi abdominal'noi khirurgii. Obshchaia reanimatologiia. 2018; 14 (5): 4-15 (in Russian).

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