Skin reactions to cardiac drugs: a clinical case
- Authors: Nevozinskaia Z.A.1,2, Piruzian A.L.3, Korsunskaia I.M.3
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Affiliations:
- Pirogov Russian National Research Medical University
- Moscow Scientific and Practical Center for Dermatovenereology and Cosmetology
- Center for Theoretical Problems of Physicochemical Pharmacology
- Issue: Vol 22, No 10 (2020)
- Pages: 80-82
- Section: Articles
- URL: https://journals.rcsi.science/2075-1753/article/view/95368
- DOI: https://doi.org/10.26442/20751753.2020.10.200267
- ID: 95368
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Abstract
Drug-induced photodermatitis is an important problem in a doctor's practice. This is due to the fact that a number of drugs widely used in medicine can cause the development of photodermatitis - antibiotics and sulfonamides, non-steroidal anti-inflammatory drugs, antineoplastic drugs, diuretics, antihypertensive and antiarrhythmic drugs, antidiabetic and psychiatric drugs, tretinoin and isotretinoin, as well as some others. Drug-induced photodermatitis proceeds as phototoxic reactions. In this situation, medicinal substances in the skin can act as a photosensitizer. The pathological mechanism of development of phototoxic reactions involves both an accumulation in the skin of a substance that possess effect of a photosensitizer and the simultaneous effect of solar radiation on the skin. The photosensitizer causes rashes by increasing skin sensitivity to visible or ultraviolet part of the spectrum. This article describes the case of a 64-year-old patient who developed photodermatitis while taking amiodarone for a long time.
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##article.viewOnOriginalSite##About the authors
Zofiia A. Nevozinskaia
Pirogov Russian National Research Medical University; Moscow Scientific and Practical Center for Dermatovenereology and Cosmetologyканд. мед. наук, врач-дерматовенеролог Moscow, Russia
Anastas L. Piruzian
Center for Theoretical Problems of Physicochemical Pharmacologyд-р мед. наук, проф., гл. науч. сотр Moscow, Russia
Irina M. Korsunskaia
Center for Theoretical Problems of Physicochemical Pharmacology
Email: marykor@bk.ru
д-р мед. наук, проф., зав. лаб. Moscow, Russia
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