The role of molecular genetic factors in the development of the first episode and recurrent noncardioembolic ischemic stroke
- Authors: Shishkova V.N.1,2, Adasheva T.V.2, Stakhovskaia L.V.3, Remennik A.I.1, Valiaeva V.V.1
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Affiliations:
- Center for Speech Pathology and Neurorehabilitation
- Yevdokimov Moscow State University of Medicine and Dentistry
- Pirogov Russian National Research Medical University
- Issue: Vol 22, No 9 (2020)
- Pages: 14-22
- Section: Articles
- URL: https://journals.rcsi.science/2075-1753/article/view/95334
- DOI: https://doi.org/10.26442/20751753.2020.9.200324
- ID: 95334
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Abstract
Aim. To assess the polymorphic allele distribution of the APO A5 (rs34282181), APO A5 (rs619054), APO E (rs5174), APO C4 (rs1132899), APO H (rs4581), LPL (rs199675233), LP (a) (rs41267) genes B (rs1042031), APO B (rs676210), APO D (rs7659), ANGPT4 (rs1044250), TNF-а (rs1800620), VEGFA (rs62401172), IL8 (rs1803205), IL6 (rs56383910), MTH1801131), ADIPOQ-AS1 (rs17366743), ADIPOQ-AS1 (rs185847354), ADIPOR2 (rs12342), GRM 1 (rs1047005), GRM 3 (rs2228595), BDNF (rs6265) genes to reveal the association with the development of the first episode and recurrent noncardioembolic ischemic stroke (IS). Materials and methods. As part of the study, conducted in two stages, where the first stage is a case-control study and the second is an observational cohort study, we identified 23 variants of single-nucleotide polymorphisms in 206 patients who had the first episode of noncardioembolic IS and in 206 sex-, age- and residence-matched healthy volunteer. Polymorphisms genotyping was performed with ready-to-use TaqMan probes. Results. For single-nucleotide polymorphic variants of the ADIPOQ-AS1 (rs17366743), APO B (rs676210), APO A5 (rs619054), APO D (rs7659) and IL8 (rs1803205) genes, an association with the development of first episode of noncardioembolic IS was established. For the single-nucleotide polymorphic variant of the ADIPOR2 (rs12342) gene, an association with the protection against the development of recurrent noncardioembolic ischemic stroke was established. Conclusion. Significant associations for single-nucleotide polymorphic variants of genes with the development of first episode and recurrent noncardioembolic IS were found.
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##article.viewOnOriginalSite##About the authors
Veronika N. Shishkova
Center for Speech Pathology and Neurorehabilitation; Yevdokimov Moscow State University of Medicine and Dentistry
Email: veronika-1306@mail.ru
канд. мед. наук, ст. науч. сотр., врач-эндокринолог Moscow, Russia
Tatiana V. Adasheva
Yevdokimov Moscow State University of Medicine and Dentistryд-р мед. наук, проф. каф. поликлинической терапии Moscow, Russia
Liudmila V. Stakhovskaia
Pirogov Russian National Research Medical Universityд-р мед. наук, проф. каф. неврологии, нейрохирургии и медицинской генетики Moscow, Russia
Alla Iu. Remennik
Center for Speech Pathology and Neurorehabilitationканд. мед. наук, зав. клинико-биохимической лаб Moscow, Russia
Vera V. Valiaeva
Center for Speech Pathology and Neurorehabilitationврач-лаборант клинико-биохимической лаб Moscow, Russia
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