P2-ADRENERGIC RECEPTORS GENETIC POLYMORPHISM, CARDIOVASCULAR DISORDERS AND INFLUENCE OF P-BLOCKERS’ EFFECTIVENESS

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Abstract

A scientific review of clinical and genetic research data on the role of p2-adrenergic receptor polymorphism in the development and outcomes of cardiovascular diseases is presented. Of the greatest importance in the genetic polymorphism of p2-adrenergic receptors are three loci - Arg16Gly, Gln27Glu and Thr164Ile. Variant alleles Gly16 and Glu27 alter the degree of suppression (down-regulation) of receptor expression against the background of agonist stimulation, which also affects the response of p-blockers. The variant allele Ile164 is extremely rare and leads to a decrease in the functional activity of the receptor. Vascular effects in carriers of the Arg16 and Gln27 alleles are manifested by lower initial blood flow and significantly weakened agonist-stimulated vasodilation compared to carriers of variant alleles Gly16 and Glu27. However, their role in the development of arterial hypertension has not been confirmed. Polymorphism of p2-adre-nergic receptors showed the greatest significance in terms of its effect on cardiac function, the development of adverse outcomes and survival in chronic heart failure, acute coronary syndrome and other cardiovascular diseases. Key words: genetic polymorphism, p2-adrenergic receptors, p-blockers, cardiovascular outcomes, arterial hypertension, heart failure. For citation: Leonova M.V. p2-Adrenergic receptors genetic polymorphism, cardiovascular disorders and influence of p-blockers’ effectiveness. Consilium Medicum. 2020; 22 (5): 92-97. DOI: 10.26442/20751753.2020.5.200107

About the authors

Marina V. Leonova

Association of Clinical Pharmacologists

Email: anti23@mail.ru
д-р мед. наук, проф., чл.-кор. РАЕН, клин. фармаколог, член MOO Volgograd, Russia

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