Psyho-neurological aspects of obstructive sleep apnea syndrome

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Abstract

Obstructive sleep apnoea syndrome (OSAS) is one of the most frequent forms of sleep-disordered breathing. Increase of risk of development and progressing of most cardiovascular disorders is typical for this condition. In clinical presentation manifestations from nervous system such as severe daytime sleepiness, cognitive decline, anxiety and depressive disorders often predominate. OSAS occurs in most widespread neurologic disorders, at present a lot of studies emerge describing its interconnections. On the one hand, sleep-related breathing disorders are often a risk factor for neurological disorders and may complicate their flow; on the other hand, they are often the result of nerve diseases. Intermittent hypoxia that develops against the background of breathing disorders plays a key role in the pathophysiology of cardiovascular and neurological complications. Article presents existing studies that describe the relationship between obstructive sleep apnea syndrome and neurological diseases such as cerebral apoplexy, Alzheimer's disease, Parkinson's disease, epilepsy, neurodegenerative and neuromuscular diseases. At the present time, CPAP therapy remains the gold standard for the treatment of obstructive sleep apnea syndrome throughout the world. When neurological pathology is combined with the syndrome of obstructive sleep apnea, the addition of CPAP therapy to the main drug treatment often has a statistically significant positive effect on the course and prognosis of neurological diseases.

About the authors

Karina I. Lavrenikova

City Clinical Hospital №2 “Sosnovaia roshcha”

Email: karina1606@rambler.ru
канд. мед. наук, врач-кардиолог, ГБУЗ КО «ГКБ №2 Сосновая роща»

Evgeniia M. Elfimova

National Medical Research Center for Cardiology

канд. мед. наук, науч. сотр. лаб. апноэ сна отд. гипертонии ИКК им. А.Л. Мясникова ФГБУ «НМИЦ кардиологии»

Oksana O. Mikhailova

National Medical Research Center for Cardiology

канд. мед. наук, мл. науч. сотр. лаб. апноэ сна отд. гипертонии ИКК им. А.Л. Мясникова ФГБУ «НМИЦ кардиологии»

Narine T. Khachatryan

National Medical Research Center for Cardiology

ординатор отд. гипертонии ИКК им. А.Л. Мясникова ФГБУ «НМИЦ кардиологии»

Vera I. Fedorova

National Medical Research Center for Cardiology

д-р мед. наук, врач-невролог ИКК им. А.Л. Мясникова ФГБУ «НМИЦ кардиологии»

Aleksandr Yu. Litvin

National Medical Research Center for Cardiology 3Pirogov Russian National Research Medical University

д-р мед. наук, рук. лаб. апноэ сна, гл. науч. сотр. отд. гипертонии, проф. отд. высшего и дополнительного профессионального образования ФГБУ «НМИЦ кардиологии», проф. каф. поликлинической терапии лечебного фак-та ФГБОУ ВО «РНИМУ им. Н.И. Пирогова».

Irina E. Ohazova

National Medical Research Center for Cardiology

акад. РАН, д-р мед. наук, проф., дир. ИКК им. А.Л. Мясникова ФГБУ «НМИЦ Кардиологии»

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