ENDOTHELIN RECEPTOR ANTAGONISTS IN PULMONARY HYPERTENSION TREATMENT

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The article presents new data on the use of endothelin receptor antagonists (ERA) in treatment of patients with different variants of pulmonary hypertension. The medications mechanisms of action are described and results of clinical studies on effectiveness and safety of the medications, perspectives on ERA use in clinical practice are presented. ERA is one of the best studied class of medications recommended for use in patients with idiopathic pulmonary arterial hypertension (PAH), PAH associated with generalized scleroderma and in Eisenmenger's syndrome in early stages of pulmonary hypertension. It was shown that this group of medications had a positive effect on functional, clinical and hemodynamic parameters, and increases life expectancy and quality of life in these serious cases. These medications are effective not only as monotherapy but also in combination treatment. Among medications for PAH treatment bosentan has the best evidence-based results according to the number of randomized clinical trials. It is the only medication from this group registered in Russia for children treatment. According to Russian register data among ERA in PAH patients 31.6% of patients use bosentan, 3.6% - ambrisentan, and 2.1% - macitentan. Bosentan is the second medication after sildenafil that is being used in PAH, in 31.6 and 54.5% of patients, respectively.

About the authors

Nadezhda A. Shostak

Pirogov Russian National Research Medical University

Moscow, Russia

Alesia A. Klimenko

Pirogov Russian National Research Medical University

Moscow, Russia

Darya lu. Andriyashkina

Pirogov Russian National Research Medical University

Email: andryashkina.darya@yandex.ru
канд. мед. наук, доц. каф. факультетской терапии Moscow, Russia

Natalia A. Demidova

Pirogov Russian National Research Medical University

канд. мед. наук, ассистент каф. факультетской терапии Moscow, Russia

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