THE PLACE OF RIOCIGUAT IN THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION AND CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION

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Abstract

Pulmonary hypertension (PH) is a group of diseases characterized by a progressive increase of pressure in the pulmonary arteries and pulmonary vascular resistance, quickly leading to the right ventricular heart failure and patient death. Increasing interest in the PH problem is due to the lack of epidemiological data on the prevalence of PH, rapidly progressing diseases with severe complications and considerable mortality. If for some groups of PH (PH associated with the left heart failure or lung diseases) it all boils down to treatment and control of the underlying disease, for others (pulmonary arterial hypertension - PAH or chronic thromboembolic pulmonary hypertension - CTEPH), an attractive approach is the specific therapy, given the malignant nature of the course and the complexity of the pathogenesis of PAH. Riociguat is the first representative of a new class of PAH-specific drugs, indicated for the treatment of CTEPH, and some forms of PAH, an innovative drug that has shown a high survival rate for patients. The purpose of this article is to provide contemporary data on the management and treatment of patients, as well as the role of specific therapy and the place of riociguat in the treatment of patients with PAH and CTEPH.

About the authors

Dmitrii lu. Platonov

Tver State Medical University; Regional Clinical Hospital

Email: diplato64@mail.ru
д-р мед. наук, магистр общественного здоровья (MPH), зав. каф. терапии и кардиологии Тверь, Россия

Olga E. Iakovleva

Chelyabinsk Regional Cardiological Dispensary

рук. центра ЛГ, врач-кардиолог Челябинск, Россия

Sergei N. Bel'diev

Tver State Medical University; Regional Clinical Hospital

канд. мед. наук, доц. каф. терапии и кардиологии ФДПО, интернатуры и ординатуры, кафедры терапии и кардиологии Тверь, Россия

Nikolai V. Il'in

Republican Hospital №1 - National Medical Center

врач-кардиолог Якутск, Россия

Tatiana lu. Tomskaia

Republican Hospital №1 - National Medical Center

канд. мед. наук, зав. кардиологическим отд-нием, врач-кардиолог Якутск, Россия

Kiundiul I. Ivanov

Republican Hospital №1 - National Medical Center

д-р мед. наук, дир. Республиканского кардиологического диспансера Якутск, Россия

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