GENETIC POLYMORPHISM OF HAEMOSTASIS SYSTEM IN ISHEMIC STROKE PATIENTS IN KABARDINIAN AND BALKARIAN POPULATIONS

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Abstract

Introduction. Stroke is one of the leading causes of morbidity and mortality both in the Russian Federation and worldwide. Stroke morbidity varies significantly in different populations. Aim. To evaluate the role of genetic polymorphisms of genes related to haemostasis system as predictors of ischemic stroke (IS) in Kabardinian and Balkarian populations. Materials and methods. Allelle and genotype frequencies of 6 polymorphisms in 176 IS patients from Kabardinian and Balkarian populations and in 201 patients without stroke, matched by gender, age and ethnic origin were assessed. Polymorphic alleles of ITGB3, GP1 BA and FGB genes were assessed using real-time polymerase chain reaction. Results. Polymorphic variant rs6065 of GP1 BA gene was associated with elevated risk of IS in Kabardinian population and polymorphic variant rs1800790 of FGB gene - both in Kabardinian and Balkarian populations. Conclusion. A significant association of single nucleotide polymorphisms of GP1 BA (rs6065) and FGB (rs1800790) genes with stroke was demonstrated in Ka-bardinian and Balkarian populations.

About the authors

Liana T. Khasanova

Pirogov Russian National Research Medical University

Email: kabarda_89@mail.ru
соискатель каф. неврологии, нейрохирургии и медицинской генетики лечебного фак-та ФГБОУ ВО «РНИМУ им. Н.И. Пирогова». Москва, Россия

Petr A. Slominskiy

Pirogov Russian National Research Medical University; institute of Molecular Genetics

д-р биол. наук, проф., зам. дир. по научной работе ФГБУН ИМГ, зав. лаб. молекулярной генетики наследственных болезней ФГБУН ИМГ, ФГБОУ ВО «РНИМУ им. Н.И. Пирогова» Москва, Россия

Liudmila R. Laypanova

Pirogov Russian National Research Medical University

аспирант каф. неврологии, нейрохирургии и медицинской генетики лечебного фак-та ФГБОУ ВО «РНИМУ им. Н.И. Пирогова». Москва, Россия

Dinara T. Chipova

City Clinical Hospital №1, Nalchik

Email: kabarda_89@mail.ru
канд. мед. наук, зав. первично-сосудистым отд-нием ГБУЗ ГКБ №1 Нальчик, Россия

Vera L. Shomahova

Republican Clinical Hospital, Nalchik

канд. мед. наук, зав. отд-нием неврологии для больных с ОНМК ГБУЗ РКБ Нальчик, Россия

Nikolai A. Shamalov

Federal Center for Cerebrovascular Pathology and Stroke

д-р мед. наук, и.о. дир. ФГБУ ФЦЦПИ, гл. внештатный невролог Департамента здравоохранения г. Москвы Москва, Россия

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