Differentsial'naya diagnostika osteoartrita i podagry: osnovnye podkhody k terapii

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Abstract

The article presents differential diagnosis of osteoarthritis and gout, aspects of clinical presentation, laboratory and instrumental studies results. Algorithm on osteoarthritis management and renewed European League Against Rheumatism (EULAR) guidelines on gout treatment are presented. Aims and main principles of gout and osteoarthritis therapy are discussed. Data on mechanism of action, characteristics, clinical effectiveness and safety of diacerein (interleukine-1 inhibitor) are presented. Results of clinical studies of febuxostat (selective inhibitor of xanthinoxidase) are presented, its effectiveness in uric acid level control, possibilities of use in patients with chronic kidney disease, non-responsive or allergic to allopurinol therapy, are shown

About the authors

E. Yu Pogozheva

V.A.Nasonova Research Institute of Rheumatology

Email: lifequality@yandex.ru
канд. мед. наук, науч. сотр 115522, Russian Federation, Moscow, Kashirskoe sh., d. 34A

V. N Amirdzhanova

V.A.Nasonova Research Institute of Rheumatology

д-р мед. наук, вед. науч. сотр. 115522, Russian Federation, Moscow, Kashirskoe sh., d. 34A

A. E Karateev

V.A.Nasonova Research Institute of Rheumatology

Email: aekarat@yandex.ru
д-р мед. наук, рук. лаб. патофизиологии боли и полиморфизма скелетно-мышечных заболеваний 115522, Russian Federation, Moscow, Kashirskoe sh., d. 34A

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