Acute renal injury in obstetric practice: focus on atypical hemolytic uremic syndrome

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Abstract

Acute kidney injury (AKI) in obstetrics is a serious complication of pregnancy and postpartum period that threatens life of the mother and of the child. In recent decades the percent of AKI associated with thrombotic microangiopathies (TMA) in obstetrics has increased. Among various TMA forms that may develop in the second half of pregnancy and in postpartum period, the worst kidney injury is associated with atypical hemolytic uremic syndrome (AHUS) that is followed with AKI development in 100% of cases. In most patients AHUS is followed by multiple organ dysfunction syndrome. Modern AHUS diagnostics and undelayed start of therapy with eculizumab allows not only to save patients' lives but also to have them recovered

About the authors

Yu. V Korotchaeva

I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation

Email: lumis-j@bk.ru
доц. каф. внутренних, профессиональных болезней и ревматологии медико-профилактического фак-та 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2

N. L Kozlovskaya

A.K.Eramishantsev City Clinical Hospital of the Department of Health of Moscow

Email: nkozlovskaya@yandex.ru
д-р мед. наук, проф., рук. Центра помощи беременным с патологией почек и мочевыделительных путей 129327, Russian Federation, Moscow, ul. Lenskaya, d. 15

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