Amyloid heart disease: pathomorphology, diagnostic approaches and treatment options

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Abstract

Systemic amyloidosis is a relatively rare multisystem disease caused by the deposition of misfolded protein in various tissues and organs. The deposits are derived from several amyloidogenic precursor proteins, and the prognosis of the disease is determined both by the organ(s) involved and the type of amyloid. Cardiac involvement is a leading cause of morbidity and mortality, especially in AL- and ATTR-amyloidosis. The last decade has seen considerable progress in understanding of cardiac amyloidosis. This review focuses on changes in intracardiac hemodynamics and their evaluation using novel diagnostic approaches (strain and speckle tracking imaging, cardiovascular magnetic resonance and cardiac biomarkers). New histological typing techniques and current treatments are discussed

About the authors

A. S Rameeva

I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation

Email: anna.rameeva@yandex.ru
аспирант каф. внутренних, профессиональных болезней и ревматологии 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2

V. V Rameev

I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation

Email: vvrameev@mail.ru
канд. мед. наук, доц. каф. внутренних, профессиональных болезней и ревматологии 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2

S. V Moiseev

I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation; M.V.Lomonosov Moscow State University

Email: clinpharm@mtu-net.ru
д-р мед. наук, проф., зав. каф. внутренних, профессиональных болезней и ревматологии; проф. каф. внутренних болезней 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2; 119991, Russian Federation, Moscow, Leninskiye gory, d. 1

P. P Tao

I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation

Email: pavel.tao@mail.ru
аспирант каф. внутренних, профессиональных болезней и ревматологии 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2

L. V Kozlovskaya

I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation

д-р мед. наук, проф., проф. каф. внутренних, профессиональных болезней и ревматологии 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2

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