Trimetazidine (review of the latest foreign publications)

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Abstract

Review of the latest data of randomized studies, meta-analyses and experimental studies proving the effectiveness of trimetazidine in cardiovascular diseases and comorbid pathology.

About the authors

E. V Akatova

A.I.Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian Federation

Email: akev@list.ru
д-р мед. наук, проф. каф. госпитальной терапии №1 127473, Russian Federation, Moscow, ul. Delegatskaia, d. 20, str. 1

References

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  3. Szwed H, Sadowski Z, Elikowski W. Combination treatment in stable effort angina using trimetazidine and metoprolol Results of a randomized, double-blind, multicentre study (TRIMPOL II). Eur Heart J 2011; 22: 2267-74.
  4. Song Peng, Min Zhao, Jing Wan. The efficacy of trimetazidine on stable angina pectoris: A meta-analysis of randomized clinical trials. Int J Cardiol 2014; 177: 780-5.
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  6. Jinsong Chen, Shanshan Zhou, Jing Jin. Chronic treatment with trimetazidine after discharge reduces the incidence of restenosis in patients who received coronary stent implantation: A 1-year prospective follow-up study. doi: 10.3892/mmr.2016.5773
  7. Glezer M.G, Vygodin V.A. Anti-Anginal Effectiveness and Tolerability of Trimetazidine Modified Release 80 Mg Once Daily in Stable Angina Patients in Real-World Practice. On behalf of ODA investigators. Adv Ther. https://doi.org/10.1007/s12325-018-0756-3//
  8. Dedkova E.N, Seidlmayer L.K, Blatter L.A. Mitochondria-mediated cardioprotection by trimetazidine in rabbit heart failure. J Mol Cell Cardiol 2013. pii: S0022-2828(13)00054-0. doi: 10.1016/j.yjmcc.2013.01.016
  9. Belardinelli R, Solenghi M, Volpe L. Trimetazidine improves endothelial dysfunction in chronic heart failure: an antioxidant effect. Online publish-ahead-of-print 24 April 2007.
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  11. Dengfeng Gao, Ning Ning, Xiaolin Niu. Trimetazidine: a meta-analysis of randomised controlled trials in heart failure. Heart 2011; 97: 278-86.
  12. Lei Zhang, Yizhou Lu, Hong Jiang. Additional Use of Trimetazidine in Patients With Chronic Heart Failure A Meta-Analysis. J Am Col Cardiol 2012; 59 (10).
  13. Xiaohan Xu, Weijun Zhang, Yujie Zhou. Effect of Trimetazidine on Recurrent Angina Pectoris and Left Ventricular Structure in Elderly Multivessel Coronary Heart Disease Patients with Diabetes Mellitus After Drug-Eluting Stent Implantation: A Single-Centre, Prospective, Randomized, Double-Blind Study at 2-Year Follow-Up. Springer International Publishing Switzerland 2014. Clin Drug Invest. doi: 10.1007/s40261-014-0170-9

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