The importance of b-CrossLaps as the marker of remodelling of bony tissue in women after the conservative operation with endometrioid cysts

The conservative surgery consequences on the ovaries are the most controversial in the scientific world. The position of modern authors comes down to the fact that surgical treatment of endometrioid cysts of the ovaries serves as a background for the development of pathology not only of the reproductive system, but also leads to endocrinopathies, including disturbance of a bone metabolism. Aim of the study. The aim of this research is the bone metabolism condition assessment and ovarian reserve of reproductive-aged women after a surgical treatment of endometrioid ovarian cysts and also the study of gestagen preventive therapy effect on changes of the direction of bone metabolism processes. 27 female-patients with endometrioid cysts (the 1st group) were examined and operated. The second (control) group included 50 patients who were healthy. All patients before the operation were carried out a determination of follicle-stimulating and antimullerian hormons and also bone metabolism biochemical markers: osteocalcin and b-CrossLaps in blood serum. The results. The level of b-CrossLaps before operation in the group of patients with endometrioid cysts was almost 1.5 times higher than in the control group (0.495 and 0.371 ng/ml respectively). The bone tissue formation marker of osteocalcin in group 1 was significantly lower (1.2 times) compared to group 2 (20.19 and 23.64 ng/ml respectively). 6 months after the operation, the similar parameters were measured. In group 1, the level of b-CrossLaps decreased significantly in 1.5 times compared to the initial data (0.437 and 0.495 ng/ml respectively), and the osteocalcin index increased significantly compared to the initial data (23.67 and 20.19 ng/ml respectively). In 12 months there was a decrease of b-CrossLaps level (in 1.3 times), which has no statistically significant differences with the control group (0.385 and 0.371 ng/ml respectively). 12 months after the operation the osteocalcin in group 1 significantly increases in 1.3 times (26.07 and 20.19 ng/ml respectively), which is an indicator of the prevalence of bone formation over the osteoresorption. Conclusion. As the result of the study it was established that gestagen preventive therapy slows down osteoresorption processes in a group of women who were removed endometrioid ovarian cysts.

b-CrossLaps, ovarian reserve, osteocalcin, b-CrossLaps, endometrioid ovarian cysts, conservative operation