Traditional lifestyle change as a reason for metabolic disorders risk increase in residents of Gornaya Shoriya

Actuality. Abdominal obesity, hypertension, carbohydrate and lipid metabolism disturbance are the major components of metabolic syndrome (MS) and important risk factors for cardiovascular disease development. Lifestyle and living conditions play a significant part in MS components prevalence. Aim. To estimate prevalence of MS and carbohydrate metabolism disturbance in native and non-indigenous population of Mountain Shoria. Materials and methods. We assessed 718 people: the first group included native population (shorians) - 403 people, the second group - non-indigenous population - 315 people. All patients were divided into groups according to sex, ethnicity and age. MS was diagnosed according to International Diabetes Federation criteria. Statistical analysis was performed with Statistica 10.0 application software programs. The significance value was less than 0.05. Results. MS was diagnosed in 40.2% if inhabitants. Among native population it was found in 12.4%, in non-indigenous population - in 47.8% (р=0.00001). In native female inhabitants MS was found in 36.8%, in non-indigenous female inhabitants - in 60.7% cases (р=0.00002). Impaired fasting glycemia (IFG) was found in 11.4% native female inhabitants and in 22.6% non-indigenous female inhabitants (р=0.0004). Impaired glucose tolerance (IGT) was found in 7.6% female shorians and in 10.7% female non-shorians (р=0.204). New onset diabetes mellitus (DM) was found in 6.5% female shorians and in 8.7% female non-shorians (р=0.326), in total DM was found in 12.1%, native female inhabitants and in 16.9% non-indigenous female inhabitants (р=0.113). IFG was found in 14.7% of male shorians and in 26.7% male non-shorians (р=0.027). IGT was found in 5.1% of native male inhabitants and in 7.0% non-indigenous male inhabitants (р=0.785). New onset DM accounted for 5.0% in shorians and 2.3% in non-shorians (р=0.299), in total DM was found in в 5.9 and 7.0%, respectively (р=0.965). Conclusions. MS is more frequent in non-indigenous population than in native population. Carbohydrate metabolism disturbance (IFG, IGT, DM) was less frequent in shorians than in non-shorians mostly because of increased prevalence of IFG in non-indigenous population, irrespective of gender. A discovered negative trend in MS and carbohydrate metabolism disturbance prevalence increase that is associated with native population lifestyle change requires more active awareness education and medical interventions such as glycemia self-control

metabolic syndrome, diabetes mellitus, carbohydrate metabolism, shorians, glycemia self-control