Percutaneous coronary interventions in comparison with medical therapy in patients with chronic ischemic heart disease: results of long-term follow-up

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Abstract

Determining the optimal treatment strategy for patients with stable coronary heart disease is a matter of debate. Fr om the Register of Coronary Angiography Operations, 2 groups of patients with stable ischemic heart disease were selected. The first group consisted of 150 patients, for whom in addition to medical therapy (MT) was performed percutaneous coronary intervention (PCI). The comparison group included patients with stable coronary heart disease who were on isolated MT. The median of observation in both groups was 93 [48; 126] months. In the groups, the overall mortality rate, the presence of myocardial infarction (MI), coronary artery bypass grafting (CABG) were assessed. And also were analyzed the combined point of MACE (major adverse cardiac events), including MI, CABG and mortality. An analysis of the long-term results showed that the mortality rate in the PCI group was lower (3.5% vs 9.6%, p=0.037). In this case, the frequency of MI was higher in the group wh ere PCI was performed (16.7% vs 7.4%, p=0.018). The frequency of coronary bypass and the development of MACE events did not reveal statistically significant intergroup differences. Thus, percutaneous coronary interventions in combination with drug therapy are an effective and safe method for the treatment of stable coronary artery disease and are characterized by a significant decrease in the mortality rate in comparison only with MT. In patients with PCI, a higher incidence of non-fatal myocardial infarction is detected with remote observation.

About the authors

V. A Kuznetsov

Tyumen Cardiology Research Center of the Tomsk National Research Medical Center of the Russian Academy of Sciences

Email: Kuznets@cardio.tmn.ru
Тюменский кардиологический научный центр 625026, Russian Federation, Tyumen, ul. Melnikaite, d. 111

E. P Samoilova

Tyumen Cardiology Research Center of the Tomsk National Research Medical Center of the Russian Academy of Sciences

Email: Samoilova_elena1985@mail.ru
Тюменский кардиологический научный центр 625026, Russian Federation, Tyumen, ul. Melnikaite, d. 111

I. S Bessonov

Tyumen Cardiology Research Center of the Tomsk National Research Medical Center of the Russian Academy of Sciences

Email: bessonov@cardio.tmn.ru
Тюменский кардиологический научный центр 625026, Russian Federation, Tyumen, ul. Melnikaite, d. 111

E. P Gultyaeva

Tyumen Cardiology Research Center of the Tomsk National Research Medical Center of the Russian Academy of Sciences

Email: gultyaeva@cardio.tmn.ru
Тюменский кардиологический научный центр 625026, Russian Federation, Tyumen, ul. Melnikaite, d. 111

S. G Berdinskikh

Tyumen Cardiology Research Center of the Tomsk National Research Medical Center of the Russian Academy of Sciences

Email: berdinskikh@cardio.tmn.ru
Тюменский кардиологический научный центр 625026, Russian Federation, Tyumen, ul. Melnikaite, d. 111

E. A Gorbatenko

Tyumen Cardiology Research Center of the Tomsk National Research Medical Center of the Russian Academy of Sciences

Email: elena@cardio.tmn.ru
Тюменский кардиологический научный центр 625026, Russian Federation, Tyumen, ul. Melnikaite, d. 111

S. M Dyachkov

Tyumen Cardiology Research Center of the Tomsk National Research Medical Center of the Russian Academy of Sciences

Email: dyachkov@cardio.tmn.ru
Тюменский кардиологический научный центр 625026, Russian Federation, Tyumen, ul. Melnikaite, d. 111

E. I Yaroslavskaya

Tyumen Cardiology Research Center of the Tomsk National Research Medical Center of the Russian Academy of Sciences

Email: yaroslavskaya@cardio.tmn.ru
Тюменский кардиологический научный центр 625026, Russian Federation, Tyumen, ul. Melnikaite, d. 111

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