Electrocardiographic predictors of sudden cardiac death

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Abstract

The article deals with electrocardiographic predictors of sudden cardiac death. The authors pay attention to ventricular arrhythmias, analysis of heart rate, variability and turbulence of rhythm, electrocardiographic criteria of ischemia and myocardial hypertrophy. The role of the analysis of the microwave alternation of the wave T, ventricular late potentials and QT interval is shown. The importance of an integrated approach in stratifying the risk of sudden cardiac death and the need for further multicenter studies are noted

About the authors

V. S Nikiforov

North-West State Medical University named after I.I.Mechnikov

Email: viktor.nikiforov@szgmu.ru
д-р мед. наук, проф., проф. каф. функциональной диагностики 191015, Russian Federation, Saint Petersburg, ul. Kirochnaia, d. 41

K. V Metso

North-West State Medical University named after I.I.Mechnikov

Email: metso.kr@gmail.com
аспирант каф. функциональной диагностики 191015, Russian Federation, Saint Petersburg, ul. Kirochnaia, d. 41

References

  1. Priori S.G, Blomström-Lundqvist C, Mazzanti A et al. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC). Eur Heart J 2015; 36 (41): 2793-867.
  2. Внезапная сердечная смерть. Под ред. Е.В.Шляхто, Г.П.Арутюнова, Ю.Н.Беленкова, А.В.Ардашева. М.: Медпрактика-М, 2015.
  3. Eckart R.E, Shry E.A, Burke A.P et al. Sudden death in young adults: an autopsy-based series of a population undergoing active surveillance. J Am Coll Cardiol 2011; 58: 1254-61.
  4. Wellens H.J.J. Risk stratification for sudden cardiac death: current status and challenges for the future. Eur Heart J 2014; 35: 1642-51.
  5. Лебедев Д.С., Седов В.М., Немков А.С. и др. Имплантируемые устройства в лечении желудочковых тахиаритмий и сердечной недостаточности. СПб., 2005.
  6. Narayanan K, Chugh S.S. The 12-lead electrocardiogram and risk of sudden death: current utility and future prospects. Europace 2015; 17: ii7-ii13.
  7. Никитин А.Э., Гришаев С.Л., Свистов А.С., Никифоров В.С. Электрическая нестабильность миокарда: причины, диагностика, лечение. СПб.: ВиТ-Принт, 2010.
  8. Abdelghani S.A, Rosenthal T.M, Morin D.P. Surface Electrocardiogram Predictors of Sudden Cardiac Arrest. Ochsner J 2016; 16 (3): 280-9.
  9. Santangeli P, Muser D, Maeda S et al. Comparative effectiveness of antiarrhythmic drugs and catheter ablation for the prevention of recurrent ventricular tachycardia in patients with implantable cardioverter-defibrillators: a systematic review and meta-analysis of randomized controlled trials. Heart Rhythm 2016; 13 (7): 1552-9.
  10. Marine J.E, Shetty V, Chow G.V et al. Prevalence and prognostic significance of exercise-induced nonsustained ventricular tachycardia in asymptomatic volunteers: BLSA (Baltimore Longitudinal Study of Aging). J Am Coll Cardiol 2013; 62: 595-600.
  11. Национальные российские рекомендации по применению методики холтеровского мониторирования в клинической практике. Рос. кардиологический журн. 2014; 2 (106): 6-71.
  12. Никифоров В.С., Никитин А.Э., Тыренко В.В., Свистов А.С. Ишемическая дисфункция миокарда. М.: АПКППРО, 2005.
  13. Soliman E.Z, Elsalam M.A, Li Y. The relationship between high resting heart rate and ventricular arrhythmogenesis in patients referred to ambulatory 24 h electrocardiographic recording. Europace 2010; 12 (2): 261-5.
  14. Jouven X, Zureik M, Desnos M et al. Resting heart rate as a predictive risk factor for sudden death in middle-aged men. Cardiovasc Res 2001; 50: 373-8.
  15. Zhang D, Shen X, Qi X. Resting heart rate and all-cause and cardiovascular mortality in the general population: a metaanalysis. CMAJ 2016; 188 (3): E53-E63.
  16. Cale R, Mendes M, Brito J et al. Resting heart rate is a powerful predictor of arrhythmic events in patients with dilated cardiomyopathy and implantable cardioverter-defibrillator. Rev Port Cardiol 2011; 30: 199-212.
  17. Teodorescu C, Reinier K, Uy-Evanado A et al. Resting heart rate and risk of sudden cardiac death in the general population: influence of left ventricular systolic dysfunction and heart rate-modulating drugs. Heart Rhythm 2013; 10: 1153-8.
  18. Makarov L, Kyrileva T, Chuprova S. Short PR interval, high circadian index and bradycardia - pattern with high risk of syncope and sudden death in children with catecholaminergic ventricular tachycardia. Europ Heart J 2004; 25: 22-3.
  19. Bauer A, Malik M, Schmidt G et al. Heart rate turbulence: standards of measurement, physiological interpretation, and clinical use: International Society for Holter and Noninvasive Electrophysiology Consensus. J Am Coll Cardiol 2008; 52 (17): 1353-65.
  20. Watanabe M.A. Heart rate turbulence: a review. Indian Pacing Electrophysiol J 2003; 3 (1): 10-22.
  21. Francis J, Watanabe M.A, Schmidt G. Heart rate turbulence: a new predictor for risk of sudden cardiac death. Ann Noninvasive Electrocardiol 2005; 10 (1): 102-9.
  22. Morin D.P, Oikarinen L, Viitasalo M et al. QRS duration predicts sudden cardiac death in hypertensive patients undergoing intensive medical therapy: the LIFE study. Eur Heart J 2009; 30 (23): 2908-14.
  23. Kurl S, Makikallio T.H, Rautaharju P et al. Duration of QRS complex in resting electrocardiogram is a predictor of sudden cardiac death in men. Circulation 2012; 125: 2588-94.
  24. Loring Z, Zareba W, McNitt S et al. ECG quantification of myocardial scar and risk stratification in MADIT-II. Ann Noninvasive Electrocardiol 2013; 18: 427-35.
  25. Das M.K, Saha C, El Masry H et al. Fragmented QRS on a 12-lead ECG: a predictor of mortality and cardiac events in patients with coronary artery disease. Heart Rhythm 2007; 4 (11): 1385-92.
  26. Gong B, Li Z. Total mortality, najor adverse cardiac events, and echocardiographic-derived cardiac parameters with fragmented QRS complex. Ann Noninvasive Electrocardiol 2016; 21 (4): 404-12.
  27. Brenyo A, Pietrasik G, Barsheshet A et al. QRS fragmentation and the risk of sudden cardiac death in MADIT II. J Cardiovasc Electrophysiol 2012; 23: 1343-8.
  28. Terho H.K, Tikkanen J.T, Junttila J.M et al. Prevalence and prognostic significance of fragmented QRS complex in middle-aged subjects with and without clinical or electrocardiographic evidence of cardiac disease. Am J Cardiol 2014; 114: 141-7.
  29. Canpolat U, Kabakçi G, Aytemir K et al. Fragmented QRS complex predicts the arrhythmic events in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia. J Cardiovasc Electrophysiol 2013; 24 (11): 1260-6.
  30. Pietrasik G, Zaręba W. QRS fragmentation: diagnostic and prognostic significance. Cardiol J 2012; 19 (2): 114-21.
  31. Громова О.И., Александрова С.А., Макаренко В.Н., Голухова Е.З. Современные предикторы жизнеугрожающих аритмий. Креативная кардиология. 2012; 2: 30-46.
  32. Marcus F.I, McKenna W.J, Sherrill D et al. Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the Task Force Criteria. Eur Heart J 2010; 31 (7): 806-14.
  33. Bauer A, Guzik P, Barthel P et al. Reduced prognostic power of ventricular late potentials in post-infarction patients of the reperfusion era. Eur Heart J 2005; 26 (8): и755-761.
  34. Kitamura H, Ohnishi Y, Okajima K et al. Onset heart rate of microvolt-level T-wave alternans provides clinical and prognostic value in nonischemic dilated cardiomyopathy. J Am Coll Cardiol 2002; 39 (2): 295-300.
  35. Bloomfield D.M, Bigger J.T, Steinman R.C et al. Microvolt T-wave alternans and the risk of death or sustained ventricular arrhythmias in patients with left ventricular dysfunction. J Am Coll Cardiol 2006; 47: 456-63.
  36. Verrier R.L, Nieminen T.T. Usefulness of T-wave alternans in sudden death risk stratification and guiding medical therapy. Ann Noninvasive Electrocardiol 2010; 15 (3): 276-88.
  37. Exner D.V, Kavanagh K.M, Slawnych M.P et al.; REFINE Investigators. Noninvasiverisk assessment early after a myocardial infarction: the REFINE study. J Am Coll Cardiol 2007; 50: 2275-84.
  38. Stein P.K, Sanghavi D, Domitrovich P.P et al. Ambulatory ECG-based T-wave alternans predicts sudden cardiac death in high-risk post-MI patients with left ventricular dysfunction in the EPHESUS study. J Cardiovasc Electrophysiol 2008; 19: 1037-42.
  39. Nieminen T, Lehtimaki T, Viik J et al. T-wave alternans predicts mortality in a population undergoing a clinically in dicated exercise test. Eur Heart J 2007; 28: 2332-7.
  40. Sakaki K, Ikeda T, Miwa Y et al. Time-domain T-wave alternans measured from Holter electrocardiograms predicts cardiac mortality in patients with left ventricular dysfunction: A prospective study. Heart Rhythm 2009; 6: 332-7.
  41. Opthof T, Coronel R, Janse M.J. Is there a significant transmural gradient in repolarization time in the intact heart?: repolarization gradients in the intact heart. Circ Arrhythm Electrophysiol 2009; 2 (1): 89-96.
  42. Taggart P, Sutton P.M, Opthof T et al. Transmural repolarisation in the left ventricle in humans during normoxia and ischaemia. Cardiovasc Res 2001; 50 (3): 454-62.
  43. Gupta P, Patel C, Patel H et al. T(p-e)/QT ratio as an index of arrhythmogenesis. J Electrocardiol 2008; 41: 567-74.
  44. Liu T, Brown B.S, Wu Y et al. Blinded validation of the isolated arterially perfused rabbit ventricular wedge in preclinical assessment of drug-induced proarrhythmias. Heart Rhythm 2006; 3: 948-56.
  45. Panikkath R, Reinier K, Uy-Evanado A et al. Prolonged Tpeak-to-tend interval on the resting ECG is associated with increased risk of sudden cardiac death. Circ Arrhythm Electrophysiol 2011; 4: 441-7.
  46. Letsas K.P, Weber R, Astheimer K et al. Tpeak-Tend interval and Tpeak-Tend/QT ratio as markers of ventricular tachycardia inducibility in subjects with Brugada ECG phenotype. Europace 2010; 12: 271-4.
  47. Shimizu M, Ino H, Okeie K et al. T-peak to T-end interval may be a better predictor of high-risk patients with hypertrophic cardiomyopathy associated with a cardiac troponin I mutation than QT dispersion. Clin Cardiol 2002; 25: 335-9.
  48. Ali A, Butt N, Sheikh A.S. Early repolarization syndrome: a cause of sudden cardiac death. World J Cardiol 2015; 7 (8): 466-75.
  49. Haïssaguerre M, Derval N, Sacher F et al. Sudden cardiac arrest associated with early repolarization. N Engl J Med 2008; 358 (19): 2016-23.
  50. Tikkanen J.T, Wichmann V, Junttila M.J et al. Association of early repolarization and sudden cardiac death during an acute coronary event. Circ Arrhythm Electrophysiol 2012; 5: 714-8.
  51. Nunn L.M, Bhar-Amato J, Lowe M.D et al. Prevalence of J-point elevation in sudden arrhythmic death syndrome families. J Am Coll Cardiol 2011; 58 (3): 286-90.
  52. ESH/ESC guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 2013; 34 (28): 2159-219.
  53. Marwick T.H, Gillebert T.C, Aurigemma G et al. Recommendations on the use of echocardiography in adult hypertension: a report from the European Association of Cardiovascular Imaging (EACVI) and the American Society of Echocardiography (ASE). Eur Heart J Cardiovasc Imaging 2015; 16 (6): 577-605.
  54. Wachtell K, Okin P.M, Olsen M.H et al. Regression of electrocardiographic left ventricular hypertrophy during antihypertensive therapy and reduction in sudden cardiac death: the LIFE Study. Circulation 2007; 116: 700-5.
  55. Narayanan K, Reinier K, Teodorescu C et al. Electrocardiographic versus echocardiographic left ventricular hypertrophy and sudden cardiac arrest in the community. Heart Rhythm 2014; 11: 1040-6.
  56. Zhang Y, Post W.S, Blasco-Colmenares E et al. Electrocardiographic QT interval and mortality: a meta-analysis. Epidemiology 2011; 22: 660-70.
  57. Chugh S.S, Reinier K, Singh T et al. Determinants of prolonged QT interval and their contribution to sudden death risk in coronary artery disease: the Oregon Sudden Unexpected Death Study. Circulation 2009; 119: 663-70.
  58. Yang P, Kanki H, Drolet B et al. Allelic variants in long-QT disease genes in patients with drug-associated torsades de pointes. Circulation 2002; 105: 1943-8.

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