Side effects of non-steroidal anti-inflammatory drugs


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Abstract

The side effects of drugs, including renal and cardiovascular complications, are a topical medical problem throughout the world. The leading place in their development is occupied by non-steroidal anti-inflammatory drugs (NSAIDs), which are the most frequently prescribed classes of drugs. The mechanism of action of NSAIDs is associated with the block of synthesis of vasodilator renal prostaglandins due to inactivation of the cyclooxygenase enzyme. This can lead to the development of vasomotor nephropathy, acute tubulointerstitial nephritis, chronic kidney disease and other renal side effects. In patients with hypertension, NSAIDs can lead to both a significant increase in blood pressure and a change in the pharmacokinetics of the antihypertensive drugs. Therefore, the appointment of NSAIDs should be strictly regulated, health workers should use minimally effective doses and duration of use; need competencies in cardiovascular and renal risk factors assessment.

About the authors

A. I Dyadyk

M.Gorky Donetsk National Medical University

д-р мед. наук, проф., зав. каф. терапии фак-та интернатуры и последипломного образования 83003, Donetsk, pr. Illicha, d. 16

T. E Kugler

M.Gorky Donetsk National Medical University

Email: kugler2@mail.ru
канд. мед. наук, ассистент каф. терапии фак-та интернатуры и последипломного образования 83003, Donetsk, pr. Illicha, d. 16

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