Statins and the liver: a point of view from the gastroenterologist


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Abstract

Millions of people in the world should be given statins, and these drugs are taken by the large group of patients. Objective information concerning any adverse event associated with statin drugs is very important, because even the data showing low liver toxicity rate can lead to abrupt withdrawal or dose interruption of these life-saving drugs in a significant number of patients with increased risk of acute cardiovascular events. Statins are the agents of choice because of the existence of a dose-dependent effect and have the most significant hypolipidemic effect, and doctors can prescribe statins in a reduced dosing regimen. On the other hand, the needed drug is exposed to the minimal metabolism via the cytochrome P450 system and this can prevent the overloading of this system, drug metabolism disorders and development toxic (drug-induced) hepatitis. These effects are associated with rosuvastatin application. Rosuvastatin has the low frequency of unwanted drug reactions and best hypolipidemic activity of this class of drugs.

About the authors

A. N Kazyulin

A.I.Evdokimov Moscow State Medical and Dental University of the Ministry of Health of the Russian Federation

Email: alexander.kazyulin@yandex.ru
д-р мед. наук, проф., акад. РАЕН, проф. каф. пропедевтики внутренних болезней и гастроэнтерологии 127473, Russian Federation, Moscow, ul. Delegatskaia, d. 20, str. 1

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