Correction of late violations of atrioventricular conduction in patients with lower myocardial infarction: the case of ivabradin

The study is concerned with the possibility of eliminating late persistent abnormalities of AV-condaction of II-III grades in patients with lower MI through selective blocks of the sinus node automatic activity by ivabradine. The effect of the drug was evaluated with the reference to reduction of automatic activity rate of the sinus node on ECG. Patients were divided into three groups: the 1st group received an inhibitor of ion currents If - ivabradine in a dose of 10 mg/day, in addition to standard therapy; 2nd group received standard therapy; 3rd group received ivabradine in a dose of 15 mg/day, in addition to standard therapy. General characteristics of patients show that steadiness of AV blocks of 2-3 degrees with kept-on function of the sinus node in patients with lower MI is retained by left ventricular heart failure. The results of the observation demonstrate that the restoration of sinus rhythm with AV 1: 1 conduction in patients of all groups occurred with a decrease in the frequency of the automatic activity of the sinus node. The dependence of the outcome of treatment on the dosage of the drug was found by application of logistic regression. Use of the maximum dosage of ivabradine at 15 mg/day provides a faster and uniform decrease in the frequency of automatic activity of the sinus node and elimination of AV abnormalities than dosage of 10 mg/day.

lower myocardial infarction, frequency of automatic activity of the sinus node, AV blocks, heart failure, ivabradine