Clinical studies of rosuvastatin from the GALAXY project in the context of the new EAS/ESC-2016 recommendations on dyslipidemia Part 1


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Abstract

Hypercholesterolemia is the most important risk factor for the development and progression of atherosclerosis in almost all populations, including the Russian Federation. Inhibitors of HMG-CoA reductase (statins) - the most well-known and well-studied class of lipid-lowering drugs with a convincing evidence base for reducing the risk of cardiovascular and total mortality. Rosuvastatin (Crestor®) - statin of the 4th generation, used in daily doses of 5-40 mg, has maximal activity in inhibiting HMG-CoA reductase and, accordingly, lowering the level of low-density lipoprotein cholesterol, has been well studied in the clinical studies program GALAXY in the period 2004-2011 In 2016, the European Society for the Study of Atherosclerosis and the European Society of Cardiology (EAS/ESC) on the diagnosis and treatment of dyslipidemias published a regular recommendation, in which statin therapy in patients with high cardiovascular risk is a priority (evidence of IA). This article discusses the role of classical studies of rosuvastatin from the GALAXY project in the light of the recommendations on dyslipidemia in 2016, as well as the current strategy of treatment with HMG-CoA reductase inhibitors in primary prevention patients with type 2 diabetes mellitus, patients with carotid arteriosclerosis, and platelet stabilization issues are discussed on the background of intensive therapy with statins.

About the authors

A. V Susekov

Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation

Email: asus99@mail.ru
д-р мед. наук, проф., проф. каф. клин. фармакологии и терапии 125993, Russian Federation, Moscow, ul. Barrikadnaia, d. 2/1

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