The characteristics of pathogenesis and therapy of acute rhinosinusitis in patients with allergic rhinitis

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Abstract

The relationships between acute rhinosinusitis and allergic rhinitis are not fully understood, and therefore the question concerning the characteristics of ARS therapy in patients with concomitant allergy remains open. Multiple pathomechanisms including aspects of the immune response, specific cytokine profile, molecular mechanisms at the level of epithelial cells and intercellular matrix are common for allergic rhinitis and rhinosinusitis. The mechanism of TGCSs action is inhibition of the synthesis of proinflammatory cytokines and preventing the migration of inflammatory cells. The use of intranasal glucocorticosteroids to leveling allergic inflammation may stop the development and increase the effectiveness of acute rhinosinusitis therapy.

About the authors

A. I Kirdeeva

Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation

аспирант каф. оториноларингологии ФГБОУ ДПО РМАНПО 125993, Russian Federation, Moscow, ul. Barrikadnaia, d. 2/1

S. Ya Kosiakov

Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation

Email: serkosykov@yandex.ru
д-р мед наук, проф., зав. каф. оториноларингологии ФГБОУ ДПО РМАНПО 125993, Russian Federation, Moscow, ul. Barrikadnaia, d. 2/1

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