Functional disorders of the gallbladder in the practice of the therapist

Cover Page

Cite item

Full Text

Abstract

The article discusses the problem of functional biliary disorders, particularly functional disorders of the gallbladder: new views of etiopathogenetic mechanisms of development of this pathology, modern clinical and laboratory criteria for diagnosis, the rules of the formulation of the diagnosis, approaches to pharmacological and surgical treatment proposed working scheme of therapy and prevention of the disease, from the perspective of the Roman criteria IV taken in 2016, and our own clinical experience.

About the authors

S. N Mekhtiev

I.M.Pavlov First Saint Petersburg State Medical University of the Ministry of Health of the Russian Federation

Email: sabirm@mail.ru
д-р мед. наук, проф. каф. госпитальной терапии им. акад. М.В.Черноруцкого 197022, Russian Federation, Saint Petersburg, ul. L’va Tolstogo, d. 6/8

O. A Mekhtieva

I.M.Pavlov First Saint Petersburg State Medical University of the Ministry of Health of the Russian Federation

канд. мед. наук, доц. каф. госпитальной терапии им. акад. М.В.Черноруцкого 197022, Russian Federation, Saint Petersburg, ul. L’va Tolstogo, d. 6/8

References

  1. Ильченко А.А. Болезни желчного пузыря и желчных путей. Руководство для врачей. 2-е изд., перераб. и доп. М.: Медицинское информационное агентство, 2011.
  2. Amaral J, Xiao Z.L, Chen Q. et al. Gallbladder muscle dysfunction in patients with chronic acalculous disease. Gastroenterology 2001; 120: 506-11.
  3. Лейшнер У. Практическое руководство по заболеваниям желчных путей. М.: ГЭОТАР-Медицина, 2001.
  4. Behar J, Corazziari E, Guelrud M. et al. Functional Gallbladder and Sphincter of Oddi Disorders. Gastroenterology 2006; 130: 1498-509.
  5. Bielefeldt K, Saligram S, Zickmund S.L. et al. Cholecystectomy for biliary dyskinesia: how did we get there? Dig Dis Sci 2014; 59: 2850-63.
  6. Preston J.F, Diggs B.S, Dolan J.P. et al. Biliary dyskinesia: a surgical disease rarely found outside the United States. Am J Surg 2015; 209: 799-803.
  7. Cotton P.B, Elta G.H, Carter C.R. et al. Rome IV. Gallbladder and Sphincter of Oddi Disorders. Gastroenterology 2016; pii: S0016-5085(16)00224-9.
  8. Маев И.В., Вьючнова Е.С., Левченко О.Б. Дисфункция билиарного тракта: от патогенеза к выбору оптимальной терапии. РМЖ. 2011; 28: 1736-41
  9. Alcon S, Morales S, Camello P.J. et al. Contribution of different phospholipases and arachidonic acid metabolites in the response of gallbladder smooth muscle to cholecystokinin. Biochem Pharmacol 2002; 64: 1157-67.
  10. Lee Y.S, Kang B.K, Hwang I.K. et al. Long-term Outcomes of Symptomatic Gallbladder Sludge. J Clin Gastroenterol 2015; 49 (7): 594-8.
  11. Pozo M.J, Camello P.J, Mawe G.M. Chemical mediators of gallbladder dysmotility. Curr Med Chem 2004; 11: 1801-12.
  12. Sharma B.C, Agarwal D.K, Dhiman R.K. et al. Bile lithogenicity and gallbladder emptying in patients with microlithiasis: effect of bile acid therapy. Gastroenterology 1998; 115: 124-8.
  13. Ozden N, DiBaise J.K. Gallbladder ejection fraction and symptom outcome in patients with acalculous biliary-like pain. Dig Dis Sci 2003; 48: 890-7.
  14. Delgado-Aros S, Cremonini F, Bredenoord A.J. et al. Systematic review and meta-analysis: does gall-bladder ejection fraction on cholecystokinin cholescintigraphy predict outcome after cholecystectomy in suspected functional biliary pain? Aliment Pharmacol Ther 2003; 18: 167-74.
  15. DiBaise J.K, Richmond B.K, Ziessman H.A. et al. Cholecystokinin-cholescintigraphy in adults: consensus recommendations of an interdisciplinary panel. Clin Nucl Med 2012; 37: 63-70.
  16. Corwin M.T, Lamba R, McGahan J.P. Functional MR cholangiography of the cystic duct and sphincter of Oddi using gadoxetate disodium: is a 30-minute delay long enough? J Magn Reson Imaging 2013; 37: 993-8.
  17. Fidler J.L, Knudsen J.M, Collins D.A. et al. Prospective assessment of dynamic CT and MR cholangiography in functional biliary pain. AJR Am J Roentgenol 2013; 201: W271-W282.
  18. Abate A, Dimartino V, Spina P. et al. Hymecromone in the treatment of motor disorders of the bile ducts: a multicenter, double-blind, placebo-controlled clinical study. Drugs Exp Clin Res 2001; 27 (5-6): 223-31.
  19. Garrett E.R, Venitz J. Comparisons of detections, stabilities, and kinetics of degradation of hymecromone and its glucuronide and sulfate metabolites. J Pharm Sci 1994; 83 (1): 115-6.
  20. Hoffmann R.M, Schwarz G, Pohl C. et al. Bile acid-independent effect of hymecromone on bile secretion and common bile duct motility. DMW 2005; 130 (34-35): 1938-43.
  21. Hoult J.R, Paya M. Pharmacological and biochemical actions of simple coumarins: natural products with therapeutic potential. Gen Pharmacol 1996; 27 (4): 713-22.
  22. Najmanova I, Dosedel M, Hrdina R. et al. Cardiovascular effects of coumarins besides their antioxidant activity. Curr Top Med Chem 2015; 15 (9): 830-49.
  23. Насонова С.В., Цветкова Л.И. Опыт применения Одестона в лечении хронических заболеваний желчного пузыря и желчевыводящих путей. Рос. журн. гастроэнтерологии, гепатологии, колопроктологии. 2000; 3: 87-90.
  24. Симаненков В.И. и др. Применение урсодезоксихолевой кислоты (Урдоксы) у пациентов с дискинезиями желчевыводящих путей. Методические рекомендации. СПб.: Фармпроект, 2010.
  25. Goussous N, Kowdley G.C, Sardana N. et al. Gallbladder dysfunction: how much longer will it be controversial? Digestion 2014; 90 (3): 147-54.
  26. Carr J.A, Walls J, Bryan L.J. et al. The treatment of gallbladder dyskinesia based upon symptoms: results of a 2- year, prospective, nonrandomized, concurrent cohort study. Surg Laparosc Endosc Percutan Tech 2009; 19: 222-6.
  27. Veenstra B.R, Deal R.A, Redondo R.E et al. Long-term efficacy of laparoscopic cholecystectomy for the treatment of biliary dyskinesia. Am J Surg 2014; 207: 366-70

Copyright (c) 2017 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies