Angiotensin II receptor antagonist - candesartan in the arsenal of therapist

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Abstract

The article deals with the comparison of pharmacological characteristics and the clinical efficacy of angiotensin II receptor blockers in patients with arterial hypertension, chronic heart failure (CHF) and chronic kidney disease. High binding affinity to the angiotensin type 1 receptors, slow dissociation and repeated fixation of candesartan provide the expressed and prolonged duration of the antihypertensive and organoprotective actions. Therapeutic efficacy of candesartan is equivalent to that of other major classes of antihypertensive agents. The application of candesartan is highly effective in CHF associated with left ventricular systolic dysfunction. In the group of patients with preserved left ventricular function, candesartan efficacy is statistically significant. We show the decrease of risk of the developing atrial fibrillation in the course of candesartan treatment in hypertension patients with CHF.

About the authors

A. A Kirichenko

Russian Medical Academy of Postgraduate Education of the Ministry of Health of the Russian Federation

Email: andrey.apollonovich@yandex.ru
д-р мед. наук, проф., зав. каф. терапии ГБОУ ДПО РМАПО 125993, Russian Federation, Moscow, ul. Barrikadnaia, d. 2/1

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