Clinical aspects of application of candesartan

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Abstract

One of the key systems of the body, affecting the functioning of the heart and blood vessels, - the renin-angiotensin-aldosterone system (RAAS). Amplification RAAS activation plays an important role in the development of cardiovascular diseases. It proved that inhibition of the RAAS activity reduces the incidence of complications of cardiovascular diseases and mortality. Candesartan is a selective blocker of angiotensin II receptor type 1. Distinctive features of its pharmacokinetics and pharmacodynamics are longer duration of antihypertensive action, high selectivity and good bioavailability. In the treatment of hypertension with candesartan is able to effectively prevent the early morning rise in blood pressure. For preparation characterized cerebro and cardioprotective effects, the ability to reduce the risk of new cases of diabetes. The drug is effective in the treatment of nephropathy different genesis, including patients with a severely reduced renal function. The metabolic neutrality, the ability to prevent the development of micro - and macroangiopathy allow us to recommend the angiotensin receptor blocker in the treatment of patients with diabetes mellitus. The favorable pharmacokinetic profile of the candesartan creates performance advantage compared to other drugs of the same group.

About the authors

Yu. V Rybachkova

Yaroslavl State Medical University of the Ministry of Health of the Russian Federation

Email: julia3111@mail.ru
канд. мед. наук, ассистент каф. клин. фармакологии с курсом ИПДО ГБОУ ВПО ЯГМУ 150000, Russian Federation, Yaroslavl, ul. Revoliutsionnaia, d. 5

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