The association between gastroesophageal reflux disease and interstitial lung fibrosis in systemic sclerosis

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Abstract

Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease characterized by thickening of the skin and multiple organ involvement. Gastroesophageal reflux disease (GERD) is a common disease manifestation of SSc, as well as interstitial lung disease (ILD), the latter is the main cause of SSc related mortality. Several studies broached the issue of a potential association of GERD with SSc-ILD and indicated that microaspiration of gastric acid may cause inflammation consecutively leading to lung fibrosis. The aim of this review is to recapitulate current evidence for a link between GERD and ILD in SSc patients and emphasize the necessity of early diagnosis and treatment in order to hopefully slow down the progression of mortality driving SSc-ILD.

About the authors

A. V Sosnovskaya

I.M.Sechenov First Moscow State Medical University

Email: antonina.sosnovskaya@live.de
аспирант каф. внутренних, профессиональных болезней и пульмонологии медико-профилактического фак-та ГБОУ ВПО Первый МГМУ им. И.М.Сеченова 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2

V. V Fomin

I.M.Sechenov First Moscow State Medical University

Email: fomin_vic@mail.ru
д-р мед. наук, проф. каф. внутренних, профессиональных болезней и пульмонологии медико-профилактического фак-та, проректор по лечебной работе ГБОУ ВПО Первый МГМУ им. И.М.Сеченова 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2

M. V Lebedeva

I.M.Sechenov First Moscow State Medical University

Email: marinaamica@mail.ru
канд. мед. наук, доц. каф. внутренних, профессиональных болезней и пульмонологии медико-профилактического фак-та ГБОУ ВПО Первый МГМУ им. И.М.Сеченова 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2

E. N Popova

I.M.Sechenov First Moscow State Medical University

Email: ela12@yandex.ru
д-р мед. наук, проф. каф. внутренних, профессиональных болезней и пульмонологии медико-профилактического фак-та ГБОУ ВПО Первый МГМУ им. И.М.Сеченова 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2

N. A Muhin

I.M.Sechenov First Moscow State Medical University

Email: mukhin-nephro@yandex.ru
акад. РАН, д-р мед. наук, проф., зав. каф. внутренних, профессиональных болезней и пульмонологии медико-профилактического фак-та, дир. НОКЦ здоровьесберегающих технологий ГБОУ ВПО Первый МГМУ им. И.М.Сеченова 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2

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