New perspectives for the treatment of tension-type headache

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Abstract

In the pathogenesis of acute and chronic tension-type headache (TTH) both peripheral and central mechanismsare of key importance. An important role is played by the peculiarities of personality development, a special type of nervous system response to stress, the rapid formation of a "pain behaviour". Preventive pharmacotherapy is individually applied in frequent attacks and chronic TTH cases. Antinociceptive effect of antidepressants appears no earlier than in 2 weeks, and at the same time, often there has been increasing concern. The aim of our study was to examine the effectiveness of flupirtine (Katadolon®) in combination with an antidepressant escitalopram in patients with frequent episodic and chronic TTH. The use of flupirtine for 2 weeks in patients with TTH is accompanied by a decrease in the frequency and intensity of headaches, as well as reducing the number of additional used cupping analgesics. The combination of flupirtine and escitalopram was effective and safe in patients with chronic TTH. Flupirtine significantly increases the threshold of pain sensitivity in patients with TTH.

About the authors

A. V Amelin

I.M.Pavlov First Saint Petersburg State Medical University of the Ministry of Health of the Russian Federation

Email: avamelin@mail.ru
д-р мед. наук, проф. каф. неврологии ГБОУ ВПО Первый СПбГМУ им. акад. И.П.Павлова 197022, Russian Federation, Saint Petersburg, ul. L'va Tolstogo, d. 6/8

L. E Babayan

I.M.Pavlov First Saint Petersburg State Medical University of the Ministry of Health of the Russian Federation

аспирант каф. неврологии ГБОУ ВПО Первый СПбГМУ им. акад. И.П.Павлова 197022, Russian Federation, Saint Petersburg, ul. L'va Tolstogo, d. 6/8

M. I Myatleva

I.M.Pavlov First Saint Petersburg State Medical University of the Ministry of Health of the Russian Federation

197022, Russian Federation, Saint Petersburg, ul. L'va Tolstogo, d. 6/8

S. V Tarasova

V.D.Seredavin Samara Regional clinical hospital

д-р мед. наук, зав. неврологическим отд-нием ГБУЗ Самарская ОКБ им. В.Д.Середавина 443095, Russian Federation, Samara, ul. Tashkentskaia, d. 159

B. Ch Tumelevich

I.M.Pavlov First Saint Petersburg State Medical University of the Ministry of Health of the Russian Federation

канд. мед. наук, врач-невролог клиники нервных болезней ГБОУ ВПО Первый СПбГМУ им. акад. И.П.Павлова 197022, Russian Federation, Saint Petersburg, ul. L'va Tolstogo, d. 6/8

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