Obstructive sleep apnea syndrome and arterial hypertension: bidirectional relationship

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Abstract

Arterial hypertension (AH) is a modifiable wide-spread risk factor for common cardiovascular diseases. The large number of observations during several studies showed that obstructive sleep apnea syndrome (OSA) was an independent risk factor for AH. This article deals with OSA pathogenetic mechanisms, considering the model of bidirectional relationship between OSA and AH, as well as the effect of CPAP-therapy (Constant Positive Airway Pressure, CPAP) on blood pressure in hypertensive patients. There are many open questions concerning the pathogenesis of OSA, its effect on the cardiovascular system and prognosis, nowadays. Despite the fact that the decrease in blood pressure during CPAP-therapy in patients with OSA is usually small, a small drop in blood pressure, even a few mm Hg can significantly reduce the cardiovascular risk, but the combination of drug therapy and CPAP-therapy can result in significant decrease in blood pressure, especially in people with poorly controlled AH. Patients who have been attended clinics, specializing in the diagnosis and treatment of hypertension should be examined for the presence or absence of OSA as a possible modifiable risk factor.

About the authors

A. Yu Litvin

A.L.Myasnikov Institute of Clinical Cardiology Russian Cardiological Scientific-Industrial Complex of the Ministry of Health of the Russian Federation

Email: alelitvin@yandex.ru
д-р мед. наук, рук. лаб. апноэ сна, отд. гипертонии ИКК им. А.Л.Мясникова ФГБУ РКНПК 121552, Russian Federation, Moscow, ul. 3-ia Cherepkovskaia, d. 15a

O. O Mikhailova

A.L.Myasnikov Institute of Clinical Cardiology Russian Cardiological Scientific-Industrial Complex of the Ministry of Health of the Russian Federation

аспирант отд. гипертонии ИКК им. А.Л.Мясникова ФГБУ РКНПК 121552, Russian Federation, Moscow, ul. 3-ia Cherepkovskaia, d. 15a

E. M Elfimova

A.L.Myasnikov Institute of Clinical Cardiology Russian Cardiological Scientific-Industrial Complex of the Ministry of Health of the Russian Federation

лаборант-исследователь, лаб. апноэ сна, отд. гипертонии ИКК им. А.Л.Мясникова ФГБУ РКНПК 121552, Russian Federation, Moscow, ul. 3-ia Cherepkovskaia, d. 15a

T. D Bugaev

A.L.Myasnikov Institute of Clinical Cardiology Russian Cardiological Scientific-Industrial Complex of the Ministry of Health of the Russian Federation

аспирант отд. гипертонии ИКК им. А.Л.Мясникова ФГБУ РКНПК 121552, Russian Federation, Moscow, ul. 3-ia Cherepkovskaia, d. 15a

I. E Chazova

A.L.Myasnikov Institute of Clinical Cardiology Russian Cardiological Scientific-Industrial Complex of the Ministry of Health of the Russian Federation

чл.-кор. РАН, д-р мед. наук, проф., дир. ИКК им. А.Л.Мясникова ФГБУ РКНПК 121552, Russian Federation, Moscow, ul. 3-ia Cherepkovskaia, d. 15a

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