Some aspects of the treatment of patients after surgery on the pancreas

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Abstract

Objective: to investigate the functional state of the pancreas (P) in patients after resection of pancreas operations for complications of chronic pancreatitis calcification (CPC), and tumors of the pancreas.The study included 52 patients: 30 CPC patients, 16 of which were subjected to surgical treatment, and 22 patients after resection surgery for tumors of the pancreas. The control group consisted of 20 people, not suffering from diseases of the digestive system.The level of C-peptide in CPC patients in all studied groups was significantly reduced in comparison with the control value. No significant difference between the groups treated with conservative and surgical treatment (14 and 16 patients, respectively) was noted. And the difference was not as the whole group with surgery and between subgroups with different types of surgical treatment (draining, resection, resection-draining operation). Similar results were obtained in studies of exocrine pancreatic (fecal elastase 1).The level of C-peptide for surgery for pancreatic cancer was 0,9 ± 0,3 mg/g and 1,9±0,3 mg/g for the control group, that is, there was a significant decrease in C-peptide (p=0.0005). However, this study was limited and required further expansion.It is concluded that the CPC on the background of complicated surgeries and developing functional insufficiency of the pancreas (exocrine like and endocrine). This surgery does not affect the development of functional pancreatic insufficiency.

About the authors

L. V Vinokurova

Moscow Clinical Scientific and Practical Center of the Department of Health of Moscow

Email: vinokurova1952@mail.ru
д-р мед. наук, вед. науч. сотр. отд-ния патологии поджелудочной железы и желчевыводящих путей ГБУЗ МКНЦ 111123, Russian Federation, Moscow, sh. Entuziastov, d. 86

D. S Bordin

Moscow Clinical Scientific and Practical Center of the Department of Health of Moscow

Email: d.bordin@mknc.ru
д-р мед. наук, зав. отд. патологии поджелудочной железы, желчных путей и верхних отделов пищеварительного тракта ГБУЗ МКНЦ 111123, Russian Federation, Moscow, sh. Entuziastov, d. 86

E. A Dubtsova

Moscow Clinical Scientific and Practical Center of the Department of Health of Moscow

Email: e.dubtsova@mknc.ru
д-р мед. наук, зав. отд-нием патологии поджелудочной железы и желчевыводящих путей ГБУЗ МКНЦ 111123, Russian Federation, Moscow, sh. Entuziastov, d. 86

K. A Nikolskaia

Moscow Clinical Scientific and Practical Center of the Department of Health of Moscow

Email: gastro2@yandex.ru
канд. мед. наук, науч. сотр. отд-ния патологии поджелудочной железы и желчевыводящих путей ГБУЗ МКНЦ 111123, Russian Federation, Moscow, sh. Entuziastov, d. 86

A. V Smirnova

Moscow Clinical Scientific and Practical Center of the Department of Health of Moscow

Email: smirn-ova@mail.ru
науч. сотр. лаб. доклинических исследований ГБУЗ МКНЦ 111123, Russian Federation, Moscow, sh. Entuziastov, d. 86

G. G Varvanina

Moscow Clinical Scientific and Practical Center of the Department of Health of Moscow

Email: varvaninag@mail.ru
ст. науч. сотр. лаб. научно-диагностических исследований ГБУЗ МКНЦ 111123, Russian Federation, Moscow, sh. Entuziastov, d. 86

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