Treatment of hepatotoxic reactions to chemotherapy in patients with colorectal cancer

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Abstract

In 2013, in Russia were found 15.0% more cases of malignancies as compared to 2003. In the overall structure of the incidence of colorectal cancer is the 5th place and revealed often already at common forms of the disease, for which chemotherapy (CT) is necessary stage of treatment. Hepatotoxicity - one of the most common side effects of chemotherapy. The article assesses the effectiveness ademetionine in the treatment of liver toxicity in patients with colorectal cancer on the background of chemotherapy. According to the results of our study and literature data ademetionine is an effective hepatoprotector.

About the authors

G. V Varlan

City clinical hospital №5 of the Department of Health of Moscow

д-р мед. наук, врач-онколог, зав. отд-нием химиотерапии ГБУЗ ГКБ №5 107014, Russian Federation, Moscow, ul. Stromynka, d. 7

S. E Galtsova

City clinical hospital №5 of the Department of Health of Moscow

Email: rocalla@list.ru
врач-онколог ГБУЗ ГКБ №5 107014, Russian Federation, Moscow, ul. Stromynka, d. 7

References

  1. Bodingbauer M, Tamandl D, Schmid K et al. Size of surgical margin does not influence recurrence rates after curative liver resection for colorectal cancer liver meta - stases. Br J Surg 2007; 94: 1133-8.
  2. Brunt E.M. Nonalcoholic steatohepatitis. Semin Liver Dis 2004; 24: 3-20.
  3. Казюлин А.Н., Вельшер Л.З., Королева И.А. Проблемы гепатотоксичности при проведении противоопухолевой химиотерапии рака молочной железы и методы ее коррекции. Фарматека. 2010; 17 (211): 82-90.
  4. Казюлин А.Н., Вельшер Л.З., Королева И.А. Возможности преодоления гепатотоксичности при проведении комбинированного и комплексного лечения рака молочной железы. Эффективная фармакотерапия. 2011; 3: 66-72.
  5. Буторова Л.И., Калинин А.В., Логинов А.Ф. Лекарственные поражения печени. Учебно - методическое пособие. Институт усовершенствования врачей. ФГУ «НМХЦ им. Н.И. Пирогова». М., 2010.
  6. Lee W. Drug - induced hepatotoxicity. N Engl J Med 2003; 349: 474-85.
  7. Andrade R.J, Lucena M.I, Fernandes M.C et al. Drug - induced liver injury: an analysis of 461 incidences submitted to the Spanish registry over a 10-year period. Gastroenterology 2005; 129 (2): 512-21.
  8. Floyd J, Mirza I, Sachs B et al. Hepatotoxicity of chemotherapy. Semin Oncol 2006; 33 (1): 50-67.
  9. Rodriguez-Frias E.A, Lee W.M. Cancer chemotherapy I: hepatocellular injury. Clin Liver Dis 2007; 11 (3): 641-62.
  10. Loriot Y, Perlemuter G, Malka D et al. Drug insight: gastrointestinal and hepatic adverse effects of molecular - targeted agents in cancer therapy. Nat Clin Pract Oncol 2008; 5 (5): 268-78.
  11. Ларионова В.Б., Зейналова П.А., Снеговой А.В. и др. Предварительные результаты проспективной многоцентровой наблюдательной программы оценки популяции пациентов с ЛИПП вследствие химиотерапии, получающих Гептрал в РФ. Вестн. РОНЦ им Н.Н.Блохина. 2015; 26: 41-7.

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