Periodontal and cardiovascular diseases: In parallel or in a bundle?

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Abstract

The review deals with a multi-faceted relationship between periodontal disease and cardiovascular disease.

About the authors

D. I Trukhan

Omsk State Medical Academy of the Ministry of Health of the Russian Federation

Email: dmitry_trukhan@mail.ru
д-р мед. наук, доц., проф. каф. внутренних болезней и поликлинической терапии ГБОУ ВПО ОмГМА 644099, Russian Federation, Omsk, ul. Lenina, d. 12

L. Yu Trukhan

Omsk State Medical Academy of the Ministry of Health of the Russian Federation

канд. мед. наук, врач-стоматолог, ГБОУ ВПО ОмГМА 644099, Russian Federation, Omsk, ul. Lenina, d. 12

References

  1. Трухан Д.И., Тарасова Л.В. Рациональная фармакотерапия и лекарственная безопасность в кардиологии. Справ. поликлин. врача. 2013; 5: 21-6.
  2. Трухан Д.И., Тарасова Л.В. Оптимизация лекарственной терапии ишемической болезни сердца и артериальной гипертензии: выбор ингибитора ангиотензинпревращающего фермента. Системные гипертензии. 2014; 1: 73-7.
  3. Демографический ежегодник России. 2013. URL: http://www.gks.ru/bgd/regl/ B13_16/Main.htm
  4. Трухан Л.Ю., Трухан Д.И. Стоматологические проблемы гастроэнтерологических пациентов. Dental Tribune Russia. 2015; 2: 12.
  5. Клинические рекомендации (протоколы лечения) при диагнозе пародонтит. URL: http://www.e-stomatology.ru/director/protokols_30-09-2014/
  6. Van Dyke T.E, Starr J.R. Unraveling the link between periodontitis and cardiovascular disease. J Am Heart Assoc 2013; 2 (6): e000657.
  7. Carramolino-Cuéllar E, Tomás I, Jiménez-Soriano Y. Relationship between the oral cavity and cardiovascular diseases and metabolic syndrome. Med Oral Patol Oral Cir Bucal 2014; 19 (3): 289-94.
  8. Rettori E, De Laurentiis A, Dees W.L et al. Host neuro - immuno - endocrine responses in periodontal disease. Curr Pharm Des 2014; 20 (29): 4749-59.
  9. Gurav A.N. The association of periodontitis and metabolic syndrome. Dent Res J (Isfahan). 2014; 11 (1): 1-10.
  10. Hatipoglu H, Yaylak F, Gungor Y. A brief review on the periodontal health in metabolic syndrome patients. Diabetes Metab Syndr 2015. pii: S1871-4021(15)00020-X.
  11. Watanabe K, Cho Y.D. Periodontal disease and metabolic syndrome: a qualitative critical review of their association. Arch Oral Biol 2014; 59 (8): 855-70.
  12. Benguigui C, Bongard V, Ruidavets J.B et al. Metabolic syndrome, insulin resistance, and periodontitis: a cross - sectional study in a middle - aged French population. J Clin Periodontol 2010; 37 (7): 601-8.
  13. Timonen P, Niskanen M, Suominen-Taipale L et al. Metabolic syndrome, periodontal infection, and dental caries. J Dent Res 2010; 89 (10): 1068-73.
  14. Andriankaja O.M, Sreenivasa S, Dunford R, De Nardin E. Association between metabolic syndrome and periodontal disease. Aust Dent J 2010; 55 (3): 252-9.
  15. Patel S.P, Kalra N, Pradeep A.R et al. Association of metabolic syndrome and periodontal disease in an Indian population. J Int Acad Periodontol 2014; 16 (4): 98-102.
  16. Pires J.R, Dos Santos I.P, de Camargo L.F et al. Framingham cardiovascular risk in patients with obesity and periodontitis. J Indian Soc Periodontol 2014; 18 (1): 14-8.
  17. Zeigler C.C, Wondimu B, Marcus C, Modeer T. Pathological periodontal pockets are associated with raised diastolic blood pressure in obese adolescents. BMC Oral Health. 2015; 15 (1): 41.
  18. Bascones-Martinez A, Munoz-Corcuera M, Bascones-Ilundain J. Diabetes and periodontitis: A bidirectional relationship. Med Clin (Barc) 2014. pii: S0025-7753(14)00571-5.
  19. Трухан Д.И., Викторова И.А., Трухан Л.Ю. Изменение органов и тканей полости рта при заболеваниях внутренних органов. М.: Практическая медицина, 2012.
  20. Трухан Л.Ю. Клинико - лабораторная характеристика состояния полости рта и уровни резистентности зубов к кариесу у больных инсулинзависимым сахарным диабетом. Автореф. дис. … канд. мед. наук. Омск, 1994.
  21. Гришечкина И.А., Трухан Л.Ю., Трухан Д.И., Коншу Н.В. Оценка состояния гигиены полости рта и тканей пародонта у больных сахарным диабетом II типа. Dental Forum. 2014; 3: 45-50.
  22. Трухан Л.Ю., Тарасова Л.В., Трухан Д.И. Изменения со стороны органов и тканей полости рта при эндокринных заболеваниях. Dental Tribune Russia. 2013; 6: 19.
  23. Трухан Д.И., Тарасова Л.В., Трухан Л.Ю. Гастроэнтерологические нарушения у пациентов с сахарным диабетом. Справ. врача общей практики. 2013; 8: 51-9.
  24. Трухан Д.И., Голошубина В.В., Трухан Л.Ю. Изменение верхних отделов желудочно - кишечного тракта у пациентов с сахарным диабетом: актуальные вопросы диагностики, лечения и контроля. Справ. поликлин. врача. 2014; 11: 40-3.
  25. Трухан Л.Ю., Трухан Д.И., Викторова И.А. Изменение органов и тканей полости рта при сахарном диабете и других эндокринных заболеваниях. Материалы ХХ международной научно - практической конференции «Актуальные вопросы стоматологии». Сб. статей. Омск: Изд - во ОмГМА, 2014; с. 199-202.
  26. Franek E, Napora M, Blach A et al. Blood pressure and left ventricular mass in subjects with type 2 diabetes and gingivitis or chronic periodontitis. J Clin Periodontol 2010; 37 (10): 875-80.
  27. Franek E, Januszkiewicz-Caulier J, Blach A et al. Intima - media thickness and other markers of atherosclerosis in patients with type 2 diabetes and periodontal disease. Kardiol Pol 2012; 70 (1): 7-13.
  28. Boillot A, Bouchard P, Moss K et al. Periodontitis and retinal microcirculation in the Atherosclerosis Risk in Communities study. J Clin Periodontol 2015; 42 (4): 342-9.
  29. Bascones-Martinez A, Gonzalez-Febles J, Sanz-Esporrin J. Diabetes and periodontal disease. Review of the literature. Am J Dent 2014; 27 (2): 63-7.
  30. Zhang D.H, Yuan Q.N, Zabala P.M et al. Diabetic and cardiovascular risk in patients diagnosed with periodontitis. Aust Dent J 2014. doi: 10.1111/adj.12253.
  31. Трухан Д.И., Викторова И.А. Внутренние болезни. Кардиология. Ревматология. М.: Медицинское информационное агентство, 2013.
  32. Salvi G.E, Carollo-Bittel E, Lang N.P. Effects the diabetes mellitus on periodontal and peri - implant conditions: update on associations and risks. J Clin Periodontol 2008; 35 (8); Suppl.: 398-409.
  33. Vieira C.L, Cury P.R, Miname M.H et al. Severe periodontitis is associated with diastolic blood pressure elevation in individuals with heterozygous familial hypercholesterolemia: a pilot study. J Periodontol 2011; 82 (5): 683-8.
  34. Golpasand Hagh L, Zakavi F, Hajizadeh F, Saleki M. The association between hyperlipidemia and periodontal infection. Iran Red Crescent Med J 2014; 16 (12): e6577.
  35. Sandi R.M, Pol K.G, Basavaraj P et al. Association of Serum Cholesterol, Triglyceride, High and Low Density Lipoprotein (HDL and LDL) Levels in Chronic Periodontitis Subjects with Risk for Cardiovascular Disease (CVD): A Cross Sectional Study. J Clin Diagn Res 2014; 8 (1): 214-6.
  36. Vieira R.W. Cardiovascular and periodontal diseases. Rev Bras Cir Cardiovasc 2014; 29 (1): VII-IX.
  37. Leite A.C, Carneiro V.M, Guimaraes Mdo C. Effects of periodontal therapy on C-reactive protein and HDL in serum of subjects with periodontitis. Rev Bras Cir Cardiovasc 2014; 29 (1): 69-77.
  38. Caula A.L, Lira-Junior R, Tinoco E.M, Fischer R.G. The effect of periodontal therapy on cardiovascular risk markers: a 6-month randomized clinical trial. J Clin Periodontol 2014; 41 (9): 875-82.
  39. Tsioufis C, Kasiakogias A, Thomopoulos C, Stefanadis C. Periodontitis and blood pressure: the concept of dental hypertension. Atherosclerosis. 2011; 219 (1): 1-9.
  40. Leong X.F, Ng C.Y, Badiah B, Das S. Association between hypertension and periodontitis: possible mechanisms. Scientific World Journal 2014; 2014: 768237.
  41. Vidal F, Figueredo C.M, Cordovil I, Fischer R.G. Higher prevalence of periodontitis in patients with refractory arterial hypertension: a case - control study. Oral Dis 2011; 17 (6): 560-3.
  42. Zhang L, Li Y.F, Liang Z.Z et al. The association between chronic periodontitis and hypertension in rural adult Uygur residents. Zhonghua Xin Xue Guan Bing Za Zhi 2011; 39 (12): 1140-4.
  43. Iwashima Y, Kokubo Y, Ono T et al. Additive interaction of oral health disorders on risk of hypertension in a Japanese urban population: the Suita Study. Am J Hypertens 2014; 27 (5): 710-9.
  44. Pralhad S, Thomas B, Kushtagi P. Periodontal disease and pregnancy hypertension: a clinical correlation. J Periodontol 2013; 84 (8): 1118-25.
  45. Jockel-Schneider Y, Harks I, Haubitz I et al. Arterial stiffness and pulse wave reflection are increased in patients suffering from severe periodontitis. PLoS One 2014; 9 (8): e103449.
  46. Vidal F, Cordovil I, Figueredo C.M, Fischer R.G. Non - surgical periodontal treatment reduces cardiovascular risk in refractory hypertensive patients: a pilot study. J Clin Periodontol 2013; 40 (7): 681-7.
  47. Choi H.M, Han K, Park Y.G, Park J.B. Associations Among Oral Hygiene Behavior and Hypertension Prevalence and Control: The 2008-2010 Korea National Health and Nutrition Examination Survey. J Periodontol 2015: 1-19.
  48. Kim H.D, Sim S.J, Moon J.Y et al. Association between periodontitis and hemorrhagic stroke among Koreans: a case - control study. J Periodontol 2010; 81 (5): 658-65.
  49. Lafon A, Tala S, Ahossi V et al. Association between periodontal disease and non - fatal ischemic stroke: a case - control study. Acta Odontol Scand 2014; 72 (8): 687-93.
  50. Diouf M, Basse A, Ndiaye M et al. Stroke and periodontal disease in Senegal: case - control study. Public Health 2015. pii: S0033-3506(15)00100-6.
  51. De Stefano F, Anda R.F, Kahn H.S et al. Dental disease and risk of coronary heart disease and mortality. BMJ 1993; 306: 688-91.
  52. Wu T, Trevisan M, Genco R.J et al. Periodontal disease and risk of cerebrovascular disease: the first national health and nutrition examination survey and its follow - up study. Arch Intern Med 2000; 160: 2749-55.
  53. Beck J.D, Elter J.R, Heiss G et al. Relationship of periodontal disease to carotid artery intima - media wall thickness: the atherosclerosis risk in communities (ARIC) study. Arterioscler Thromb Vasc Biol 2001; 21: 1816-22.
  54. Meurman J.H, Sanz M, Janket S. Oral health, atherosclerosis, and cardiovascular disease. Crit Rev Oral Biol Med 2004; 15 (6): 403-13.
  55. Dietrich T, Jimenez M, Krall Kaye E.A et al. Age - dependent associations between chronic periodontitis/edentulism and risk of coronary heart disease. Circulation 2008; 117: 1668-74.
  56. Jimenez M, Krall E.A, Garcia R.I et al. Periodontitis and incidence of cerebrovascular disease in men. Ann Neurol 2009; 66: 505-12.
  57. Friedewald V.E, Kornman K.S, Beck J.D et al. The American Journal of Cardiology and Journal of Periodontology Editors' Consensus: periodontitis and atherosclerotic cardiovascular disease. J Periodontol 2009; 80: 1021-32.
  58. Schenkein H.A, Loos B.G. Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases. J Periodontol 2013; 84 (4 Suppl.): 51-69.
  59. Kholy K.E, Genco R.J, van Dyke T.E. Oral infections and cardiovascular disease. Trends Endocrinol Metab 2015. pii: S1043-2760(15)00045-4.
  60. Friedewald V.E, Kornman K.S, Beck J.D et al. The American Journal of Cardiology and Journal of Periodontology editors' consensus: periodontitis and atherosclerotic cardiovascular disease. J Periodontol 2009; 80: 1021-32.
  61. Kodovazenitis G, Pitsavos C, Papadimitriou L et al. Periodontal disease is associated with higher levels of C-reactive protein in non - diabetic, non - smoking acute myocardial infarction patients. J Dent 2011; 39 (12): 849-54.
  62. Heaton B, Applebaum K.M, Rothman K.J et al. The influence of prevalent cohort bias in the association between periodontal disease progression and incident coronary heart disease. Ann Epidemiol 2014; 24 (10): 741-6.
  63. Marfil-Alvarez R, Mesa F, Arrebola-Moreno A et al. Acute myocardial infarct size is related to periodontitis extent and severity. J Dent Res 2014; 93 (10): 993-8.
  64. Orlandi M, Suvan J, Petrie A et al. Association between periodontal disease and its treatment, flow - mediated dilatation and carotid intima - media thickness: a systematic review and meta - analysis. Atherosclerosis 2014; 236 (1): 39-46.
  65. Yu H, Qi L.T, Liu L.S et al. Association of Carotid Intima - media Thickness and Atherosclerotic Plaque with Periodontal Status. J Dent Res 2014; 93 (8): 744-51.
  66. Desvarieux M, Demmer R.T, Jacobs D.R et al. Changes in Clinical and Microbiological Periodontal Profiles Relate to Progression of Carotid Intima-Media Thickness: The Oral Infections and Vascular Disease Epidemiology Study. J Am Heart Assoc 2013; 2 (6): e000254.
  67. Desvarieux M, Demmer R.T, Rundek T et al. Periodontal microbiota and carotid intima - media thickness: the oral infections and vascular disease epidemiology study (INVEST). Circulation 2005; 111: 576-82.
  68. Yakob M, Soder B, Meurman J.H et al. Prevotella nigrescens and Porphyromonas gingivalis are associated with signs of carotid atherosclerosis in subjects with and without periodontitis. J Periodontal Res 2011; 46 (6): 749-55.
  69. Tapashetti R.P, Guvva S, Patil S.R et al. C-reactive Protein as Predict of Increased Carotid Intima Media Thickness in Patients with Chronic Periodontitis. J Int Oral Health 2014; 6 (4): 47-52.
  70. Liu R, Moroi M, Yamamoto M et al. Presence and severity of Chlamydia pneumoniae and Cytomegalovirus infection on coronary plaques are associated with acute coronary syndromes. Int Heart J 2006; 47 (4): 511-9.
  71. Offenbacher S, Beck J.D, Moss K et al. Results from Periodontitis and Vascular Events (PAVE) Study: a pilot multicentered, randomized, controlled trial to study effects of periodontal therapy in a secondary prevention model of cardiovascular disease. J Periodontol 2009; 80 (2): 190-201.
  72. Oliveira F.J, Vieira R.W, Coelho O.R et al. Inflamacao sistemica causada pela periodontite cronica em pacientes vitimas de ataque cardiaco isquemico agudo. Rev Bras Cir Cardiovasc 2010; 25 (1): 51-8.
  73. Leishman S.J, Do H.L, Ford P.J. Cardiovascular disease and the role of oral bacteria. J Oral Microbiol 2010; 2. doi: 10.3402/jom.v2i0.5781.
  74. Soares G.M, Teles F, Starr J.R et al. Effects of Azithromycin, Metronidazole, Amoxicillin, and Metronidazole plus Amoxicillin on an In Vitro Polymicrobial Subgingival Biofilm Model. Antimicrob Agents Chemother 2015; 59 (5): 2791-8.
  75. Socranski S, Haffajee A.D. Periodontal microbial ecology. Peridontol 2000. 2005; 38: 135-87.
  76. Olsen I. From the acta prize lecture 2014: the periodontal - systemic connection seen from a microbiological standpoint. Acta Odontol Scand 2015: 1-6.
  77. Pussinen P.J, Nyyssonen K, Alfthan G et al. Serum antibody levels to actinobacillus actinomycetemcomitans predict the risk for coronary heart disease. Arterioscler Thromb Vasc Biol 2005; 25: 833-8.
  78. Beck J.D, Eke P, Lin D et al. Associations between IgG antibody to oral organisms and carotid intima - medial thickness in community - dwelling adults. Atherosclerosis 2005; 183: 342-8.
  79. Beck J.D, Eke P, Heiss G et al. Periodontal disease and coronary heart disease: a reappraisal of the exposure. Circulation 2005; 112: 19-24.
  80. Pussinen P.J, Alfthan G, Jousilahti P et al. Systemic exposure to Porphyromonas gingivalis predicts incident stroke. Atherosclerosis 2007; 193: 222-8.
  81. Pussinen P.J, Tuomisto K, Jousilahti P et al. Endotoxemia, immune response to periodontal pathogens, and systemic inflammation associate with incident cardiovascular disease events. Arterioscler Thromb Vasc Biol 2007; 27: 1433-9.
  82. Serra e Silva Filho W, Casarin R.C, Nicolela E.L. Microbial diversity similarities in periodontal pockets and atheromatous plaques of cardiovascular disease patients. PLoS One 2014; 9 (10): e109761.
  83. Kozarov E, Dorn B, Shelburne C et al. Human atherosclerotic plaque contains viable invasive Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans. Arterioscler Thromb Vasc Biol 2005; 25: 17-8.
  84. Kozarov Е. Bacterial invasion of vascular cell types: vascular infectology and atherogenesis. Future Cardiol 2012; 8 (1): 123-38.
  85. Humphrey L.L, Fu R, Buckley D.I et al. Periodontal disease and coronary heart disease incidence: a systematic review and meta - analysis. J Gen Intern Med. 2008;23(12):2079-2086.
  86. Gibson F.C, Hong C, Chou H.H et al. Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation 2004; 109: 2801-6.
  87. Reyes L, Herrera D, Kozarov E et al. Periodontal bacterial invasion and infection: contribution to atherosclerotic pathology. J Periodontol 2013; 84: 30-50.
  88. Jain A, Batista E.L, Serhan C et al. Role for periodontitis in the progression of lipid deposition in an animal model. Infect Immun 2003; 71: 6012-8.
  89. Page R.C. The pathobiology of periodontal disease may affect systemic diseases: inversion of a paradigm. Ann Periodontol 1998; 3 (1): 108-20.
  90. Loos B.G, Craandijk J, Hoek F.J et al. Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. J Periodontol 2000; 71 (10): 1528-34.
  91. Badran Z, Struillou X, Verner C et al. Periodontitis as a risk factor for systemic disease: Are microparticles the missing link? Med Hypotheses 2015. pii: S0306-9877(15)00090-0.
  92. Kalburgi V, Sravya L, Warad S et al. Role of systemic markers in periodontal diseases: a possible inflammatory burden and risk factor for cardiovascular diseases? Ann Med Health Sci Res 2014; 4 (3): 388-92.
  93. Sharma A, Astekar M, Metgud R et al. A study of C-reactive protein, lipid metabolism and peripheral blood to identify a link between periodontitis and cardiovascular disease. Biotech Histochem 2014; 89 (8): 577-82.
  94. Ramirez J.H, Parra B, Gutierrez S et al. Biomarkers of cardiovascular disease are increased in untreated chronic periodontitis: a case control study. Aust Dent J 2014; 59 (1): 29-36.

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