The role of glimepiride in combination with metformin in modern practice of using antihyperglycemic therapy for type 2 diabetes mellitus

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Abstract

The article describes the role of sulfonylurea medications in modern recommendations concerning the treatment of patients with diabetes mellitus type 2. We showed the characteristics of mechanism of action and pharmacokinetics of glimepiride associated with positive differences in the efficacy of treatment, the frequency of hypoglycemic reactions, effects on weight, the frequency of side effects and complications of the treatment. We described the results of clinical studies concerning extrapancreatic effects of glimepiride (effect on the synthesis of glycogen, lipid metabolism, ischemic preconditioning, insulin resistance index). We studied the efficacy of glimepiride (Amaryl) in combination with the rapid-release metformin fixed combination of Amaryl and metformin (Amaryl M).

About the authors

L. A Zhukova

Kursk State Medical University of the Ministry of Health of the Russian Federation

Email: profzhukova@mail.ru
д-р мед. наук, проф., зав. каф. эндокринологии ГБОУ ВПО КГМУ 305041, Russian Federation, Kursk, ul. Karla Marksa, d. 3

A. A Gulamov

Kursk State Medical University of the Ministry of Health of the Russian Federation

канд. мед. наук, доц. каф. эндокринологии ГБОУ ВПО КГМУ 305041, Russian Federation, Kursk, ul. Karla Marksa, d. 3

E. V Kuznetsov

Kursk State Medical University of the Ministry of Health of the Russian Federation

ассистент каф. эндокринологии ГБОУ ВПО КГМУ 305041, Russian Federation, Kursk, ul. Karla Marksa, d. 3

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