Gastric cancer: risk factors and possible prevention

  • Authors: Maev I.V1, Andreev D.N1
  • Affiliations:
    1. ГБОУ ВПО Московский государственный медико-стоматологический университет им. А.И.Евдокимова Минздрава России
  • Issue: Vol 16, No 12 (2014)
  • Pages: 45-50
  • Section: Articles
  • URL: https://journals.rcsi.science/2075-1753/article/view/94206
  • ID: 94206

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Abstract

Among all human malignancies gastric cancer (GC) is in 4th place in the incidence of, and in the 2nd - among the leading cancer mortality causes world - wide. Despite the trend of morbidity reduction in some parts of the world, GC continues to represent a serious clinical problem, because in most cases the disease is diagnosed at later stages and is associated with poor prognosis. Carcinogenesis GC is a complex and multifactorial process defines various causative and triggering factors, including genetic and epigenetic alterations. Many risk factors of gastric cancer, have been identified so far, and Helicobacter pylori, smoking, high salt intake and genetic predisposition are the most studied. Given the key role of H. pylori in the genesis of gastric cancer, eradication of the pathogen is regarded as the main tactic of cancer prevention.

About the authors

I. V Maev

ГБОУ ВПО Московский государственный медико-стоматологический университет им. А.И.Евдокимова Минздрава России

д-р мед. наук, проф., чл.-кор. РАН, зав. каф. пропедевтики внутренних болезней и гастроэнтерологии

D. N Andreev

ГБОУ ВПО Московский государственный медико-стоматологический университет им. А.И.Евдокимова Минздрава России

Email: dna-mit8@mail.ru
ассистент каф. пропедевтики внутренних болезней и гастроэнтерологии

References

  1. Abrams A.J, Wang T.C. Adenocarcinoma and other tumors of the stomach. In: Feldman M, Friedman L.S, Brandt L.J (eds): Sleisenger and Fordtran’s Gastrointestinal and Liver Disease. Pathophysiology/Diagnosis/Management. 9th ed. Philadelphia: WB Saunders, 2010.
  2. Jemal A, Bray F, Center M.M et al. Global cancer statistics. CA Cancer J Clin. 2011; 61: 69-90.
  3. Crew K.D, Neugut A.I. Epidemiology of gastric cancer. World J Gastroenterol 2006; 12 (3): 354-62.
  4. Parkin D.M. International variation. Oncogene 2004; 23: 6329-40.
  5. Parkin D.M, Whelan S.L, Ferlay J. Cancer Incidence in Five Continents, vol VII. Lyon, France: International Agency for Research on Cancer, 1997: 822-3.
  6. Nomura A. Stomach Cancer. In: Schottenfeld D, Fraumeni J.F, eds. Cancer Epidemiology and Prevention. 2nd ed. New York: Oxford University Press, 1996: 707-24.
  7. Parsonnet J. The incidence of Helicobacter pylori infection. Aliment Pharmacol Ther 1995; 9 (Suppl. 2): 45-51.
  8. Pandey R, Misra V, Misra S.P et al. Helicobacter pylori and gastric cancer. Asian Pac J Cancer Prev 2010; 11 (3): 583-8.
  9. Correa P. Helicobacter pylori and gastric cancer: state of the art. Cancer Epidemiol Biomarkers Prev 1996; 5: 477-81.
  10. Barreto-Zuniga R, Maruyama M, Kato Y et al. Significance of Helicobacter pylori infection as a risk factor in gastric cancer: serological and histological studies. J Gastroenterol 1997; 32: 289-94.
  11. Miehlke S, Hackelsberger A, Meining A et al. Histological diagnosis of Helicobacter pylori gastritis is predictive of a high risk of gastric carcinoma. Int J Cancer 1997; 73: 837-9.
  12. Nomura A.M, Stemmermann G.N, Chyou P.H. Gastric cancer among the Japanese in Hawaii. Jpn J Cancer Res 1995; 86: 916-23.
  13. Forman D, Newell D.G, Fullerton F et al. Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation. BMJ 1991; 302: 1302-5.
  14. Kamangar F, Qiao Y.L, Blaser M.J et al. Helicobacter pylori and oesophageal and gastric cancers in a prospective study in China. Br J Cancer 2007; 96:172-6.
  15. Uemura N, Okamoto S, Yamamoto S et al. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med 2001; 345: 784-9.
  16. Аруин Л.И. Из 100 инфицированных Helicobacter pylori РЖ возникает у двоих. Кто они? Эксперим. и клин. гастроэнтерология. 2004; 1: 12-8.
  17. Parsonnet J, Friedman G.D, Orentreich N, Vogelman H. Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection. Gut 1997; 40: 297-301.
  18. Hatakeyama M. Helicobacter pylori CagA and gastric cancer: a paradigm for hit - and - run carcinogenesis. Cell Host Microbe 2014; 15 (3): 306-16.
  19. Vicari J.J, Peek R.M, Falk G.W et al. The seroprevalence of cagA-positive Helicobacter pylori strains in the spectrum of gastroesophageal reflux disease. Gastroenterology 1998; 115: 50-7.
  20. Azuma T, Yamakawa A, Yamazaki S et al. Correlation between variation of the 3’ region of the CagA gene in Helicobacter pylori and disease outcome in Japan. J Infect Dis 2002; 186: 1621-30.
  21. Wroblewski L.E, Peek R.M.Jr. Helicobacter pylori in gastric carcinogenesis mechanisms. Gastroenterol Clin N Am 2013; 42: 285-98.
  22. Mowat C, Carswell A, Wirz A, Mc Coll K.E. Omeprazole and dietary nitrate independently affect levels of vitamin C and nitrite in gastric juice. Gastroenterology 1999; 116:813-22.
  23. Oldreive C, Rice-Evans C. The mechanisms for nitration and nitrotyrosine formation in vitro and in vivo: Impact of diet. Free Radic Res 2001; 35: 215-31.
  24. Sugimura T, Fujimura S, Baba T. Tumor production in the glandular stomach and alimentary tract of the rat by N-methyl-N -nitro- N-nitrosoguanidine. Cancer Res 1970; 30: 455-65.
  25. Bartsch H, Ohshima H, Pignatelli B, Calmels S. Human exposure to endogenous N-nitroso compounds: Quantitative estimates in subjects at high risk for cancer of the oral cavity, oesophagus, stomach and urinary bladder. Cancer Surv 1989; 8: 335-62.
  26. Knekt P, Jarvinen R, Dich J, Hakulinen T. Risk of colorectal and other gastro - intestinal cancers after exposure to nitrate, nitrite and N- nitroso compounds: A follow - up study. Int J Cancer 1999; 80: 852-6.
  27. Jakszyn P, Bingham S, Pera G et al. Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study. Carcinogenesis 2006; 27:1497-501.
  28. Van Loon A.J, Botterweck A.A, Goldbohm R.A et al. Intake of nitrate and nitrite and the risk of gastric cancer: A prospective cohort study. Br J Cancer 1998; 78:129-35.
  29. Fox J.G, Dangler C.A, Taylor N.S et al. High - salt diet induces gastric epithelial hyperplasia and parietal cell loss, and enhances Helicobacter pylori colonization in C57BL/6 mice. Cancer Res 1999; 59: 4823-8.
  30. Correa P, Haenszel W, Cuello C et al. Gastric precancerous process in a high risk population: Cohort follow - up. Cancer Res 1990; 50: 4737-40.
  31. Ramon J.M, Serra L, Cerdo C, Oromi J. Dietary factors and gastric cancer risk. A case - control study in Spain. Cancer 1993; 71: 1731-5.
  32. Nazario C.M, Szklo M, Diamond E et al. Salt and gastric cancer: A case - control study in Puerto Rico. Int J Epidemiol 1993; 22: 790-7.
  33. Gonzalez C.A, Jakszyn P, Pera G et al. Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC). J Natl Cancer Inst 2006; 98: 345-54.
  34. Gonzalez C.A, Pera G, Agudo A et al. Fruit and vegetable intake and the risk of stomach and oesophagus adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). Int J Cancer 2006; 118: 2559-66.
  35. Loh J.T, Torres V.J, Cover T.L. Regulation of Helicobacter pylori cagA expression in response to salt. Cancer Res 2007; 67: 4709-15.
  36. Gamboa-Dominguez A, Ubbelohde T, Saqui-Salces M et al. Salt and stress synergize H. pylori - induced gastric lesions, cell proliferation, and p21 expression in Mongolian gerbils. Dig Dis Sci 2007; 52:1517-26.
  37. Kuper H, Boffetta P, Adami H.O. Tobacco use and cancer causation: Association by tumour type. J Intern Med 2002; 252: 206-24.
  38. Gonzalez C.A, Pera G, Agudo A, et al. Smoking and the risk of gastric cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC). Int J Cancer 2003; 107: 629-34.
  39. Sung N.Y, Choi K.S, Park E.C et al. Smoking, alcohol and gastric cancer risk in Korean men: The National Health Insurance Corporation Study. Br J Cancer 2007; 97: 700-4.
  40. Sjodahl K, Lu Y, Nilsen T.I et al. Smoking and alcohol drinking in relation to risk of gastric cancer: A population - based, prospective cohort study. Int J Cancer 2007; 120: 128-32.
  41. Ladeiras-Lopes R, Pereira A.K, Nogueira A et al. Smoking and gastric cancer: Systematic review and meta - analysis of cohort studies. Cancer Causes Control 2008; 19: 689-701.
  42. Freedman N.D, Abnet C.C, Leitzmann M.F et al. A prospective study of tobacco, alcohol, and the risk of esophageal and gastric cancer subtypes. Am J Epidemiol 2007; 165: 1424-33.
  43. Larsson S.C, Bergkvist L, Naslund I et al. Vitamin A, retinol, and carotenoids and the risk of gastric cancer: A prospective cohort study. Am J Clin Nutr 2007; 85: 497-503.
  44. Larsson S.C, Giovannucci E, Wolk A. Alcoholic beverage consumption and gastric cancer risk: a prospective population - based study in women. Int J Cancer 2007; 120: 373-7.
  45. Gammon M.D, Schoenberg J.B, Ahsan H et al. Tobacco, alcohol, and socioeconomic status and adenocarcinomas of the esophagus and gastric cardia. J Natl Cancer Inst 1997; 89: 1277-84.
  46. Renehan A.G, Tyson M, Egger M et al. Body - mass index and incidence of cancer: a systematic review and meta - analysis of prospective observational studies. Lancet 2008; 371: 569-78.
  47. Abnet C.C, Freedman N.D, Hollenbeck A.R et al. A prospective study of BMI and risk of oesophageal and gastric adenocarcinoma. Eur J Cancer 2008; 44: 465-71.
  48. Merry A.H, Schouten L.J, Goldbohm R.A, van den Brandt P.A. Body mass index, height and risk of adenocarcinoma of the oesophagus and gastric cardia: A prospective cohort study. Gut 2007; 56: 1503-11.
  49. Mac Innis R.J, English D.R, Hopper J.L, Giles G.G. Body size and composition and the risk of gastric and oesophageal adenocarcinoma. Int J Cancer 2006; 118: 2628-31.
  50. Chow W.H, Blot W.J, Vaughan T.L et al. Body mass index and risk of adenocarcinomas of the esophagus and gastric cardia. J Natl Cancer Inst 1998; 90:150-5.
  51. Lindblad M, Rodriguez L.A, Lagergren J. Body mass, tobacco and alcohol and risk of esophageal, gastric cardia, and gastric non - cardia adenocarcinoma among men and women in a nested case - control study. Cancer Causes Control 2005; 16: 285-94.
  52. Zanghieri G, Di Gregorio C, Sacchetti C et al. Familial occurrence of gastric cancer in the 2-year experience of a population - based registry. Cancer 1990; 66: 2047-51.
  53. Brenner H, Arndt V, Sturmer T et al. Individual and joint contribution of family history and Helicobacter pylori infection to the risk of gastric carcinoma. Cancer 2000; 88: 274-9.
  54. Parsonnet J. When heredity is infectious. Gastroenterology 2000; 118: 222-4.
  55. Leung W.K, Ng E.K, Chan W.Y et al. Risk factors associated with the development of intestinal metaplasia in first - degree relatives of gastric cancer patients. Cancer Epidemiol Biomarkers Prev 2005; 14: 2982-6.
  56. Zwick A, Munir M, Ryan C.K et al. Gastric adenocarcinoma and dysplasia in fundic gland polyps of a patient with attenuated adenomatous polyposis coli. Gastroenterology 1997; 113: 659-63.
  57. Bianchi L.K, Burke C.A, Bennett A.E et al. Fundic gland polyp dysplasia is common in familial adenomatous polyposis. Clin Gastroenterol Hepatol 2008; 6:180-5.
  58. Aarnio M, Salovaara R, Aaltonen L.A et al. Features of gastric cancer in hereditary non - polyposis colorectal cancer syndrome. Int J Cancer 1997; 74: 551-5.
  59. Coburn M.C, Pricolo V.E, De Luca F.G, Bland K.I. Malignant potential in intestinal juvenile polyposis syndromes. Ann Surg Oncol 1995; 2: 386-91.
  60. Howe J.R, Mitros F.A, Summers R.W. The risk of gastrointestinal carcinoma in familial juvenile polyposis. Ann Surg Oncol 1998; 5: 751-6.
  61. Tamura G, Yin J, Wang S et al. E-cadherin gene promoter hypermethylation in primary human gastric carcinomas. J Natl Cancer Inst 2000; 92: 569-73.
  62. Yoon K.A, Ku J.L, Yang H.K et al. Germline mutations of E-cadherin gene in Korean familial gastric cancer patients. J Hum Genet 1999; 44: 177-80.
  63. El-Omar E.M, Carrington M, Chow W.H et al. Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature 2000; 404:398-402.
  64. El-Omar E.M, Rabkin C.S, Gammon M.D et al. Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology 2003; 124: 1193-201.
  65. Cheng D, Hao Y, Zhou W, Ma Y. Positive association between Interleukin-8 -251A>T polymorphism and susceptibility to gastric carcinogenesis: a meta - analysis. Cancer Cell Int 2013; 13 (1): 100.
  66. Wadhwa R, Song S, Lee J.S et al. Gastric cancer - molecular and clinical dimensions. Nat Rev Clin Oncol 2013; 10 (11): 643-55.
  67. Shimizu N, Ikehara Y, Inada K et al. Eradication diminishes enhancing effects of Helicobacter pylori infection on glandular stomach carcinogenesis in Mongolian gerbils. Cancer Res 2000; 60: 1512-4.
  68. Nozaki K, Shimizu N, Ikehara Y et al. Effect of early eradication on Helicobacter pylori - related gastric carcinogenesis in Mongolian gerbils. Cancer Sci 2003; 94: 235-9.
  69. Cai X, Carlson J, Stoicov C et al. Helicobacter felis eradication restores normal architecture and inhibits gastric cancer progression in C57BL/6 mice. Gastroenterology 2005; 128: 1937-52.
  70. You W.C, Brown L.M, Zhang L et al. Randomized double - blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions. J Natl Cancer Inst 2006; 98: 974-83.
  71. Take S, Mizuno M, Ishiki K et al. The effect of eradicating helicobacter pylori on the development of gastric cancer in patients with peptic ulcer disease. Am J Gastroenterol 2005; 100: 1037e42.
  72. Fuccio L, Zagari R.M, Eusebi L.H et al. Meta - analysis: can Helicobacter pylori eradication treatment reduce the risk for gastric cancer? Ann Intern Med 2009; 151: 121e8.
  73. De Vries A.C, Kuipers E.J. Review article: helicobacter pylori eradication for the prevention of gastric cancer. Aliment Pharmacol Ther 2007; 26(Suppl. 2): 25e35.
  74. De Vries A.C, Kuipers E.J. Epidemiology of premalignant gastric lesions: implications for the development of screening and surveillance strategies. Helicobacter 2007; 12 (Suppl. 2): 22-31.
  75. Wang J, Xu L, Shi R et al. Gastric atrophy and intestinal metaplasia before and after Helicobacter pylori eradication: a meta - analysis. Digestion 2011; 83: 253e60.
  76. Rokkas T, Pistiolas D, Sechopoulos P et al. The long - term impact of Helicobacter pylori eradication on gastric histology: a systematic review and meta - analysis. Helicobacter 2007; 12 (Suppl. 2): 32e8.
  77. Howe L.R, Dannenberg A.J. A role for cyclooxygenase-2 inhibitors in the prevention and treatment of cancer. Semin Oncol 2002; 29 (3 Suppl. 11):111-9.
  78. Saukkonen K, Rintahaka J, Sivula A et al. Cyclooxygenase-2 and gastric carcinogenesis. Apmis 2003; 111: 915-25.
  79. Wang W.H, Huang J.Q, Zheng G.F et al. Non - steroidal anti - inflammatory drug use and the risk of gastric cancer: a systematic review and meta - analysis. J Natl Cancer Inst 2003; 95 (23): 1784-91.
  80. Yang P, Zhou Y, Chen B et al. Aspirin use and the risk of gastric cancer: a meta - analysis. Dig Dis Sci 2010; 55 (6): 1533-9.
  81. Kobayashi M, Tsubono Y, Sasazuki S et al. Vegetables, fruit and risk of gastric cancer in Japan: A 10-year follow - up of the JPHC Study Cohort I. Int J Cancer 2002; 102: 39-44.
  82. Larsson S.C, Bergkvist L, Wolk A. Fruit and vegetable consumption and incidence of gastric cancer: A prospective study. Cancer Epidemiol Biomarkers Prev 2006; 15: 1998-2001.
  83. Freedman N.D, Subar A.F, Hollenbeck A.R et al. Fruit and vegetable intake and gastric cancer risk in a large United States prospective cohort study. Cancer Causes Control 2008; 19: 459-67.
  84. Zhang Z, Xu G, Ma M et al. Dietary fiber intake reduces risk for gastric cancer: a meta - analysis. Gastroenterology 2013; 145: 113.
  85. Plummer M, Vivas J, Lopez G et al. Chemoprevention of precancerous gastric lesions with antioxidant vitamin supplementation: A randomized trial in a high - risk population. J Natl Cancer Inst 2007; 99: 137-46.
  86. Masuda M, Suzui M, Lim J.T, Weinstein I.B. Epigallocatechin-3-gallate inhibits activation of HER-2/neu and downstream signaling pathways in human head and neck and breast carcinoma cells. Clin Cancer Res 2003; 9: 3486-91.
  87. Henning S.M, Wang P, Carpenter C.L, Heber D. Epigenetic effects of green tea polyphenols in cancer. Epigenomics 2013; 5 (6): 729-41.
  88. Hou I.C, Amarnani S, Chong M.T, Bishayee A. Green tea and the risk of gastric cancer: epidemiological evidence. World J Gastroenterol 2013; 19 (24): 3713-22.

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