Mogut li kholesterin vysokoy plotnosti i triglitseridy byt' otdel'nymi mishenyami dlya gipolipidemicheskoy terapii?


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Abstract

В настоящее время все более очевидно, что нормализация уровня общего холестерина (ХС) является важной задачей гиполипидемической терапии, однако такой подход лишь частично может решить проблему снижения индивидуального сердечно-сосудистого риска. Это связано с тем, что у значительной части пациентов (например, у лиц с метаболическим синдромом – МС, ожирением, сахарным диабетом, гиперурикемией) имеется повышение уровня триглицеридов (ТГ) и снижение липопротеинов высокой плотности (ЛПВП).Являются ли ТГ и ЛПВП самостоятельными мишенями при гиполипидемической терапии? Основной проблемой в настоящее время является отсутствие четких рекомендаций по коррекции уровня ТГ и ЛПВП.

About the authors

S. V Nedogoda

Волгоградский государственный медицинский университет

References

  1. Assmann G, Schulte H, von Eckardstein A. Hypertriglyceridemia and elevated lipoprotein(a) are risk factors for major coronary events in middle - aged men. Am J Cardiol 1996; 77: 1179–84.
  2. Ballantyne C.M, Olsson A.G, Cook T.J et al. Influence of low high - density lipoprotein cholesterol and elevated triglyceride on coronary heart disease events and response to simvastatin therapy in 4S. Circulation 2001; 104: 3046–51.
  3. Bansal S, Buring J.E, Rifai N et al. Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women. JAMA 2007; 207: 309–16.
  4. Cannon C.P, Braunwald E, Mc Cabe C.H et al. Pravastatin or Atorvastatin Evaluation and Infection Therapy - Thrombolysis in Myocardial Infarction 22 Investigators. Intensive versus moderate lipid lowering with statins after acute coronary syndromes. N Engl J Med 2004; 350: 1495–504.
  5. Carroll M.D, Lacher D.A, Sorlie P.D et al. Trends in serum lipids and lipoproteins of adults, 1960–2002. JAMA 2005; 294: 1773–81.
  6. Davidson M.H, Stein E.A, Bays H.E et al. Comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin, and pravastatin across doses (STELLAR trial). Am J Cardiol 2003; 92: 152–60.
  7. Davidson M, Ma P, Stein E.A et al. Comparison of effects on low - density lipoprotein cholesterol with rosuvastatin versus atorvastatin in patients with type IIa or IIb hypercholesterolemia. Am J Cardiol 2002; 89: 268–75.
  8. Dunbar R.L, Rader D.J. Demystifying triglycerides: A practical approach for the clinician. Cleveland Clinic J Med 2005; 5: 661–8.
  9. Ellison R.C, Zhang Y, Qureshi M.M et al. Lifestyle determinants of high - density lipoprotein cholesterol: the National Heart, Lung, and Blood Institute Family Heart Study. Am Heart J 2004; 147: 529–35.
  10. Erdogan D, Gullu H, Caliskan M et al. Fasting hypertriglyceridaemia increases carotid intima - media thickness and impairs coronary microvascular functions in non - obese middle aged women but not in men. Heart 2006; 92: 259–60.
  11. Ford E.S, Liu S. Glycemic index and serum high - density lipoprotein cholesterol concentration among US adults. Arch Intern Med 2001; 161: 572–6.
  12. Genest J.J, Mc Namara J.R, Salem D.N, Schaefer E.J. Prevalence of risk factors in men with premature coronary artery disease. Am J Cardiol 1991; 67 (15): 1185–9.
  13. Ginsberg H.N. Nonpharmacologic management of low levels of high - density lipoprotein cholesterol. Am J Cardiol 2000; Suppl. 86: 41–5.
  14. Grundy S.M, Cleeman J.I, Merz C.N.B et al. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation 2004; 110: 227–39.
  15. Hata Y, Nakajima K. Life - style and serum lipids and lipoproteins. J Atheroscler Throm 2000; 7: 177–97.
  16. Hayness W.G. Triglyceride-Rich Lipoproteins and Vascular Function. Arteriosclerosis, Thrombosis, and Vascular Biology 2003; 23: 153–61.
  17. Imamura H, Teshima K, Miyamoto N, Shirota T. Cigarette smoking, high - density lipoprotein cholesterol subfractions, and lecithin: Cholesterol acyltransferase in young women. Metabolism 2002; 51: 1313–6.
  18. Imke C, Rodriguez B.L, Grove J.S et al. Are remnant - like particles independent predictors of coronary heart disease incidence? The Honolulu Heart study. Arterioscler Thromb Vasc Biol 2005; 25: 1718–22.
  19. Koppes L.L, Twisk J.W, Van Mechelen W et al. Cross - sectional and longitudinal relationship between alcohol consumption and lipids, blood pressure and body weight indices. J Stud Alcohol 2005; 66: 713–21.
  20. Lee W.Y, Jung C.H, Park J.S et al. Effects of smoking, alcohol, exercise, education, and family history on the metabolic syndrome as defined by the ATP III. Diabetes Res Clin Pract 2005; 67: 70–7
  21. Ma Y, Chiriboga D.E, Olendzki B.C et al. Association between Carbohydrate Intake and Serum Lipids. J Am Coll Nutr 2005; 25: 155–63.
  22. Manninen V, Tenkanen L, Koskinen P et al. Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study. Implications for treatment. Circulation 1992; 85: 37–45.
  23. Mazza A, Tikhonoff V, Schiavon L, Casiglia E. Triglycerides + hygh - density - lipoprotein - cholesterol dyslipidaemia, a coronary risk factor in elderly women: the Cardiovascular Study in the elderly. Intern Med J 2005; 35: 604–10.
  24. Miller M, Cannon C.P, Murphy S.A et al. PROVE IT - TIMI 22 Investigators. Impact of triglyceride levels beyond low - density lipoprotein cholesterol after acute coronary syndrome in the PROVE IT-TIMI 22 trial. J Am Coll Cardiol 2008; 51: 724–30.
  25. Miller M. Current perspectives on the management of hypertriglyceridemia. Am Heart J 2000; 140: 232–40.
  26. Nagra P.K, Ho A.C, Dugan J.D. Jr. Lipemia retinalis associated with branch retinal vein occlusion. Am J Ophthalmol 2003; 135: 539–42.
  27. Nash D.T, Cardiovascular risk beyond LDL - C levels. Other lipids are performers in cholesterol story. Postgrad Med 2004; 116 (3): 11–5.
  28. No authors listed. Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease: the Bezafibrate Infarction Prevention (BIP) study. Circulation 2000; 102: 21–7.
  29. Nordestgaard B.G, Benn M, Schnohr P, Tybjaerg-Hansen A. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA 2007; 298: 299–308.
  30. Onat A, Sansoy V, Yildirim B. Which fasting triglyceride levels best reflect coronary risk? Evidence from the Turkish Adult Risk Factor Study. Clin Cardiol 2001; 24: 9–14.
  31. Sacks F.M. The relative role of low - density lipoprotein cholesterol and high - density lipoprotein cholesterol in coronary artery disease: evidence from large - scale statin and fibrate trials. Am J Cardiol 2001; 88 (suppl.): 14N–18N.
  32. Sarwar N, Danesh J, Eiriksdottir G et al. Triglycerides and the risk of coronary heart disease. 10158 incident Cases Among 262525 Participants in 29 Western Prospective Studies. Circulation 2007; 115: 450–8.
  33. Schillaci G, Pirro M, Mannarini E. Serum triglyceride concentration and coronary heart disease. Circulation 2002; 105: 54–5.
  34. Singh I.M, Shishehbor M.H, Ansell B.J. High-Density Lipoprotein as a Therapeutic Target A Systematic Review. JAMA 2007; 298 (7): 786–98.
  35. von Muhlen D, Langer R.D, Barrett-Connor E. Sex and time differences in the associations of non - high - density lipoprotein cholesterol versus other lipid and lipoprotein factors in the prediction of cardiovascular death (The Rancho Bernardo Study). Am J Cardiol 2003; 91: 1311–5.
  36. Yang E.J, Chung .HK, Kim W.Y et al. Carbohydrate intake is associated with diet quality and risk factors for cardiovascular diseases in US adults: NHANES III. J Am Coll Nutr 2003; 22: 71–9.
  37. Чепетова Т.В., Мешков А.Н. Гипертриглицеридемия: этиология, патогенез, диагностика. Кардиоваск. тер. и профил. 2006; 5: 94–100.

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