Dvoynoe otkrytoe parallel'noe issledovanie vliyaniya kvinaprila po sravneniyu s lizinoprilom na disfunktsiyu endoteliya u kuryashchikh patsientov, stradayushchikh myagkoy i umerennoy arterial'noy gipertenziey v sochetanii so stenokardiey i imeyushchikh mikroal'buminuriyu i dislipidemiyu


Cite item

Full Text

Abstract

До настоящего времени остается неясным, как курение влияет на тонус сосудов, в частности коронарных артерий, предопределяя изменение коронарного кровотока.Цель исследования – сравнить эффективность выраженности влияния двух ингибиторов ангиотензинпревращающего фермента (ИАПФ) лизиноприла и квинаприла на эндотелиальную дисфункцию и факторы риска у длительно курящих пациентов с артериальной гипертензией (АГ).В нашем исследовании впервые проводилось прямое сопоставление двух ИАПФ, различающихся сродством к тканевой ренин-ангиотензин-альдостероновой системе.

About the authors

G. P Arutyunov

ГОУ ВПО РГМУ Росздрава

Zh. D Kobalava

РУДН

Yu. A Karpov

ФГУ РКНПК Федерального агентства по высокотехнологичной медицинской помощи, Москва

T. K Chernyavskaya

ГОУ ВПО РГМУ Росздрава

R. S Ovchinnikov

ГКБ №4, Москва

N. A Bylova

ГКБ №4, Москва

M. I Dzidzariya

ГКБ №4, Москва

O. N Volgina

ГКБ №4, Москва

P. V Mitrofanov

ГКБ №4, Москва

K. B Shavgulidze

ГКБ №4, Москва

E. B Liskina

ГОУ ВПО РГМУ Росздрава

A. A Beytuganov

ГОУ ВПО РГМУ Росздрава

K. I Ivanov

ГКБ №4, Москва

N. O Balanina

ГКБ №4, Москва

N. Yu Voevodina

ГКБ №4, Москва

L. V Stepanova

ГКБ №4, Москва

A. A Marfunina

ГКБ №4, Москва

References

  1. Онищенко Г.Г. Информационное письмо главного санитарного врача. 04.05.2000. www.nonsmoking.ru
  2. EUROASPIRE II Study Group. Lifestyle and risk factor management and use of drug therapies in coronary patients from 15 countries; principal results from EUROASPIRE II Euro Heart Survey Programme. Eur Heart J. 2001; 22 (7): 554–72.
  3. Александров А.А., Шальнова С.А., Деев А.Д. Распространение курения среди врачей РФ. Информационная статья.www.nonsmoking.ru
  4. Pittilo R.M, Cigarette smoking, endothelial injury and atherosclerosis. J. Smoking Related Dis., 1993; 4: 17–25.
  5. Hamasaki H, Sato J, Masuda H et al. Effect of nicotine on the intimal hyperplasia after endothelial removal of the rabbit carotid artery. Gen Pharmacol 1997; 28 (5): 653–9.
  6. Davis J.W, Shelton L, Eigenberg D.A et al. Effects of tobacco and non - tobacco cigarette smoking on endothelium and platelets. Clin Pharmacol Ther 1985; 37 (5): 529–33.
  7. Vita J.A, Treasure C.B, Yeung A.C et al. Patients with evidence of coronary endothelial dysfunction as assessed by acetylcholine infusion demonstrate marked increase in sensitivity to constrictor effects of catecholamines. Circulation. 1992; 85 (4): 1390–7.
  8. Nabel E.G, Ganz P, Gordon J.B et al., Dilation of normal and constriction of atherosclerotic coronary arteries caused by the cold pressor test. Circulation. 1988; 77 (1): 43–52.
  9. Butler R, Morris A.D, Struthers A.D. Lisinopril improves endothelial function in chronic cigarette smokers. Clin Sci (Lond). 2001; 101 (1): 53–8.
  10. Higgins J.P. Can angiotensin - converting enzyme inhibitors reverse atherosclerosis? South Med J. 2003; 96 (6): 569–79.
  11. Chalon S, Moreno H. Jr, Hoffman B.B et al. Angiotensin - converting enzyme inhibition improves venous endothelial dysfunction in chronic smokers. Clin Pharmacol Ther. 1999; 65 (3): 295–303.
  12. Pellegrini M.P, Newby D.E, Johnston N.R et al. Vitamin C has no effect on endothelium - dependent vasomotion and acute endogenous fibrinolysis in healthy smokers. J Cardiovasc Pharmacol. 2004; 44 (1): 117–124.
  13. Schindler T.H, Magosaki N, Jeserich M et al. Effect of ascorbic acid on endothelial dysfunction of epicardial coronary arteries in chronic smokers assessed by cold pressor testing. Cardiology. 2000; 94 (4): 239–46.
  14. Drossos G.E, Toumpoulis I.K, Katritsis D.G et al. Is vitamin C superior to diltiazem for radial artery vasodilation in patients awaiting coronary artery bypass grafting? J Thorac Cardiovasc Surg. 2003; 125 (2): 330–5.
  15. Zanchetti A, Hansson L, Clement D et al. Benefits and risks of more intensive blood pressure lowering in hypertensive patients of the HOT study with different risk profiles: does a J - shaped curve exist in smokers? J Hypertens. 2003; 21 (4): 797–804.
  16. Schlaifer J.D, Wargovich T.J, O'Neill B et al. Effects of quinapril on coronary blood flow in coronary artery disease patients with endoth elial dysfunction. TREND Investigators. Trial on Reversing Endothelial Dysfunction. Am J Cardiol. 1997; 80 (12): 1594–7.
  17. Yamasaki K, Aoki M, Makino H et al. Effect of nifedipine on endothelial function in normotensive smokers: potential contribution of increase in circulating hepatocyte growth factor. J Hum Hypertens. 2004; 18 (10): 701–5.
  18. Oida K, Ebata K, Kanehara H et al. Effect of cilostazol on impaired vasodilatory response of the brachial artery to ischemia in smokers. J Atheroscler Thromb. 2003; 10 (2): 93–8.
  19. Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high - risk individuals: a randomised placebo - controlled trial. Lancet. 2002; 360 (9326): 7–22.
  20. Milionis H.J, Rizos E, Mikhailidis D.P. Smoking diminishes the beneficial effect of statins: observations from the landmark trials. Angiology. 2001; 52 (9): 575–87.

Copyright (c) 2008 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies