Antiaritmicheskiy effekt statinov pri zheludochkovykh narusheniyakh ritma vysokoy gradatsii i mertsatel'noy aritmii

  • Authors: Aronov D.M1
  • Affiliations:
    1. ФГУ Государственный научно-исследовательский центр профилактической медицины Росздрава, Москва
  • Issue: Vol 9, No 11 (2007)
  • Pages: 90-96
  • Section: Articles
  • URL: https://journals.rcsi.science/2075-1753/article/view/92547
  • ID: 92547

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Abstract

Основное назначение статинов – антиатеросклеротическое действие после продолжительного (не менее 3–5 лет) лечения. В данном случае речь идет о первоначальном предназначении статинов – блокировать синтез холестерина на уровне ГМККоА-редуктазы, что приводит к развитию гипохолестеринемии и далее – к антиатеросклеротическому эффекту. Но фактически оказалось, что статины кроме гиполипидемического и, следовательно, антиатеросклеротического эффекта обладают самыми разнообразными терапевтическими свойствами, которые позволяют им влиять не только на нарушенные функции сердечно-сосудистой системы, но и различных других органов и систем, не имеющих отношения к обмену липидов и атеросклерозу. Эти дополнительные (плейотропные) нелипидные свойства статинов систематизированы в таблице. Как видно, среди этих свойств числится и такое свойство статинов, как антиаритмическое. Впервые антиаритмическое свойство статинов было показано в исследовании J. De Sutter и соавт. (2000 г.).

About the authors

D. M Aronov

ФГУ Государственный научно-исследовательский центр профилактической медицины Росздрава, Москва

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