Complex of amino acids, choline, and B-group vitamins for the improvement of early-stage metabolic dysfunction-associated steatotic liver disease (Translation to Russian)

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Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the most common cause of chronic liver disease worldwide, affecting an estimated 25% of the global population. Up to 80% of individuals with hepatic steatosis remain asymptomatic and may show no biochemical abnormalities, meaning that MASLD is frequently silent until complications occur, which makes early diagnosis challenging. Lifestyle modification, including dietary changes, regular physical activity, and sustained weight reduction, is the cornerstone of MASLD management. At present, however, there is still no universally standardized pharmacological treatment for MASLD all over the world, and management continues to rely primarily on lifestyle modification. The amino acids and B-group vitamin complex is expected to be effective in treating the early stage of steatohepatosis and steatohepatitis, reducing aminotransferases levels and decreasing liver fat cell accumulation.

This article is published in the journal Consilium Medicum in Russian with the permission of the copyright holders. The original article: Murane N, Sprudza KL, Ivanova J, Zalizko P. Complex of Amino Acids, Choline, and B-Group Vitamins for the Improvement of Early-Stage Metabolic Dysfunction-Associated Steatotic Liver Disease. Health. 2025;17:1252-71. DOI: 10.4236/health.2025.1710083 is distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0).

About the authors

Natalija Murane

University of Latvia

Email: polina.zalizko@lu.lv

Student

Latvia, Riga

Klinta Luize Sprudza

Riga Stradins University

Email: polina.zalizko@lu.lv
ORCID iD: 0009-0001-6686-021X

D. Sci. (Med.)

Latvia, Riga

Jelena Ivanova

Riga Stradins University; Olivia Clinic

Email: polina.zalizko@lu.lv

gastroenterologist

Latvia, Riga; Riga

Polina Zalizko

University of Latvia; Riga Stradins University; Olivia Clinic

Author for correspondence.
Email: polina.zalizko@lu.lv
ORCID iD: 0000-0003-3657-6418

D. Sci. (Med.)

Latvia, Riga; Riga; Riga

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* Murane N, Sprudza KL, Ivanova J, Zalizko P. Complex of Amino Acids, Choline, and B-Group Vitamins for the Improvement of Early-Stage Metabolic Dysfunction-Associated Steatotic Liver Disease. Health. 2025;17:1252-71. https://doi.org/10.4236/health.2025.1710083
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Оригинал статьи опубликован в Health 2025;17:1252-71.
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