Prospective short-term observational study of glucosamine complex with chondroprotectors effect in adults with diagnosed knee and/or hip osteoarthritis (Translation to Russian)

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Abstract

Background. Osteoarthritis (OA) of the knee and/or hip is a chronic degenerative disease that severely impacts quality of life. Current treatments, such as NSAIDs, provide only symptomatic relief and are associated with significant side effects. This study evaluates whether short-term supplementation with a glucosamine complex (glucosamine, chondroitin, hyaluronic acid, omega-3, type II collagen) can improve OA symptoms.

Materials and methods. A prospective observational study recruited 200 OA patients from family physician practices in Latvia. Patients were divided into 1) Study group (n=100) receiving Artroveron® 5in1 COMPLEX WITH OMEGA-3 (Glucosamine hydrochloride 300 mg, Omega-3 fatty acids 100 mg, Chondroitin sulfate 50 mg, Hyaluronic acid 20 mg, Type II collagen 20 mg); 2) Control group (n=100) receiving no chondroprotectors. Pain levels were assessed at baseline and after 30 days using: Western Ontario and McMaster Universities Arthritis Index (WOMAC), Visual Analogue Scale (VAS).

Results. Study group (glucosamine complex) had a statistically significant reduction in pain scores compared to the control group (p<0.001). WOMAC pain score decreased from 7.3±3.8 to 6.0±3.6 (p<0.001). WOMAC stiffness score improved from 3.4±1.7 to 2.6±1.8 (p<0.001). WOMAC difficulty score reduced from 26.6±11.3 to 21.0±11.5 (p<0.001). VAS pain score decreased from 5.8±1.6 to 4.9±1.5 in the study group, compared to 4.8±1.8 to 4.2±2.0 in controls (p<0.001).

Conclusion. Shortterm supplementation with Artroveron® 5in1 COMPLEX WITH OMEGA-3 significantly reduced OA pain and stiffness compared to untreated control group. These findings suggest that glucosamine supplementation may serve as an effective alternative for OA symptom management.

This article is published in the journal Consilium Medicum in Russian with the permission of the copyright holders. The original article: Puce M, Medne-Simsone A, Sprudza K. Prospective Short-Term Observational Study of Glucosamine Complex with Chondroprotectors Effect in Adults with Diagnosed Knee and/or Hip Osteoarthritis. Health 2025;17:405-424. doi: 10.4236/health.2025.174027 is distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0).

About the authors

Maija Puce

Dinas Puhartes Family Doctors Practice Ltd.

Author for correspondence.
Email: editor@omnidoctor.ru

Medical Doctor (MD), General Practitioner

Latvia, Sigulda

Anna Medne-Simsone

Annas Mednes-Simsones Family Doctors Practice Ltd.

Email: editor@omnidoctor.ru

Medical Doctor (MD), General Practitioner

Latvia, Bauska

Klinta Luize Sprudza

Riga Stradins University

Email: editor@omnidoctor.ru

MBBS (Bachelor of Medicine, Bachelor of Surgery), Faculty of Medicine

Latvia, Riga

References

  1. Coaccioli S, Sarzi-Puttini P, Zis P, et al. Osteoarthritis: New Insight on Its Pathophysiology. J Clinl Med. 2022;11(20):6013. doi: 10.3390/jcm11206013
  2. Anandacoomarasamy A, March L. Current Evidence for Osteoarthritis Treatments. Ther Adv Musculoskelet Dis. 2010;2(1):17-28. doi: 10.1177/1759720x09359889
  3. Sukhikh S, Babich O, Prosekov A, et al. Future of Chondroprotectors in the Treatment of Degenerative Processes of Connective Tissue. Pharmaceuticals (Basel). 2020;13(9):220. doi: 10.3390/ph13090220
  4. Zhu X, Sang L, Wu D, et al. Effectiveness and Safety of Glucosamine and Chondroitin for the Treatment of Osteoarthritis: A Meta-Analysis of Randomized Controlled Trials. J Orthop Surg Res. 2018;13(1):170. doi: 10.1186/s13018-018-0871-5
  5. Honvo G, Reginster J, Rabenda V, et al. Safety of Symptomatic Slow-Acting Drugs for Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis. Drugs Aging. 2019;36:65-99. doi: 10.1007/s40266-019-00662-z
  6. Arden NK, Perry TA, Bannuru RR, et al. Non-Surgical Management of Knee Osteoarthritis: Comparison of ESCEO and OARSI 2019 Guidelines. Nat Rev Rheumatol. 2021:17(1):59-66. doi: 10.1038/s41584-020-00523-9
  7. Téllez Méndez R, Cabeza L, González Yibirin M, et al. Randomized, Double-Blind, Double-Masked, Parallel Group Clinical Study to Compare the Effectiveness of Diclofenac Potassium 150 Mg, LP OD, vs Diclofenac Potassium 50 Mg, TID, Three Times a Day, in Knee Osteoarthritis. Int J Clin Med. 2023;14:239-49. doi: 10.4236/ijcm.2023.145020
  8. Wang Y, Li D, Lv Z, et al. Efficacy and Safety of Gutong Patch Compared with Nsaids for Knee Osteoarthritis: A Real-World Multicenter, Prospective Cohort Study in China. Pharmacol Res. 2023;197:106954. doi: 10.1016/j.phrs.2023.106954
  9. Fox B. Glucosamine Hydrochloride for the Treatment of Osteoarthritis Symptoms. Clin Interv Aging. 2007;2(4):599-604. doi: 10.2147/cia.s1632
  10. Migliore A. Effectiveness and Utility of Hyaluronic Acid in Osteoarthritis. Clinl Cases Miner Bone Metab. 2015;12(1):31-3. doi: 10.11138/ccmbm/2015.12.1.031
  11. Materkowski M. Efficacy Treatment of Osteoarthritis with Combine Chondroitin and Glucosamine. Ortop Traumatol Rehabil. 2021;23(3):239-44. doi: 10.5604/01.3001.0014.9842
  12. Vasiliadis HS, Tsikopoulos K. Glucosamine and Chondroitin for the Treatment of Osteoarthritis. World J Orthop. 2017;8(1):1-11. doi: 10.5312/wjo.v8.i1.1
  13. Gupta RC, Lall R, Srivastava A, Sinha A. Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory. Front Vet Sci. 2019;6:192. doi: 10.3389/fvets.2019.00192
  14. Bakilan F, Armagan O, Ozgen M, et al. Effects of Native Type II Collagen Treatment on Knee Osteoarthritis: A Randomized Controlled Trial. Eurasian J Med. 2016;48(2):95-101. doi: 10.5152/eurasianjmed.2015.15030
  15. Cordingley DM, Cornish SM. Omega-3 Fatty Acids for the Management of Osteoarthritis: A Narrative Review. Nutrients. 2022;14(16):3362. doi: 10.3390/nu14163362
  16. Meng Z, Liu J, Zhou N. Efficacy and Safety of the Combination of Glucosamine and Chondroitin for Knee Osteoarthritis: A Systematic Review and Meta-Analysis. Arch Orthop Trauma Surg. 2023;143(1):409-21. doi: 10.1007/s00402-021-04326-9
  17. Heller GZ, Manuguerra M, Chow R. How to Analyze the Visual Analogue Scale: Myths, Truths and Clinical Relevance. Scand J Pain. 2016;13:67-75. doi: 10.1016/j.sjpain.2016.06.012
  18. Silva MDC, Perriman DM, Fearon AM, et al. Minimal Important Change and Difference for Knee Osteoarthritis Outcome Measurement Tools after Non-Surgical Interventions: A Systematic Review. BMJ Open. 2023;13(5):e063026. doi: 10.1136/bmjopen-2022-063026
  19. Clement ND, Bardgett M, Weir D, et al. What Is the Minimum Clinically Important Difference for the WOMAC Index after TKA? Clin Orthop Relat Res. 2018;476(10):2005-14. doi: 10.1097/corr.0000000000000444
  20. Olaiya OR, Abraha B, Gallo L, et al. Estimating the Minimal Clinically Important Difference on the Visual Analogue Scale for Carpometacarpal Thumb Joint Osteoarthritis. HAND. 2025;20(5):720-4. doi: 10.1177/15589447241235344
  21. Sumsuzzman DM, Khan ZA, Jung JH, et al. Comparative Efficacy of Glucosamine-Based Combination Therapies in Alleviating Knee Osteoarthritis Pain: A Systematic Review and Network Meta-Analysis. J Clin Med. 2024;13(23):7444. doi: 10.3390/jcm13237444
  22. Varagani DS, Kumar DMU, Ahamad T, et al. Role of Glucosamine and Hyaluronic Acid in the Treatment of Osteoarthritis. Int J Advanc Res Biol Sci. 2024;11(7):112-26. doi: 10.22192/ijarbs.2024.11.07.011
  23. Jerosch J. Effects of Glucosamine and Chondroitin Sulfate on Cartilage Metabolism in OA: Outlook on Other Nutrient Partners Especially Omega-3 Fatty Acids. Int J Rheumatol. 2011;2011:969012. doi: 10.1155/2011/969012
  24. Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, Chondroitin Sulfate, and the Two in Combination for Painful Knee Osteoarthritis. New Engl J Med. 2006;354(8):795-808. doi: 10.1056/nejmoa052771
  25. Čeh T, Šarabon N. Effects of Adding Glucosamine or Glucosamine Combined with Chondroitin to Exercise on Pain and Physical Function in Adults with Knee Osteoarthritis: A Systematic Review and Meta-Analysis. Eur J Transl Myol. 2023;33(4):12013. doi: 10.4081/ejtm.2023.12013
  26. Sconza C, Romano D, Scaturro D, et al. Safety and Efficacy of Hybrid Cooperative Complexes of Sodium Hyaluronate and Sodium Chondroitin for the Treatment of Patients with Symptomatic Knee Osteoarthritis. Rheumatol Ther. 2024;11:381-95. doi: 10.1007/s40744-024-00643-8
  27. Price D, Staud R, Robinson M. How Should We Use the Visual Analogue Scale (VAS) in Rehabilitation Outcomes? II: Visual Analogue Scales as Ratio Scales: An Alternative to the View of Kersten et al. J Rehabil Med. 2012;44:800-1. doi: 10.2340/16501977-1031
  28. Neogi T. The Epidemiology and Impact of Pain in Osteoarthritis. Osteoarthritis Cartilage. 2013;21(9):1145-53. doi: 10.1016/j.joca.2013.03.018
  29. Kim C, Nevitt MC, Niu J, et al. Association of Hip Pain with Radiographic Evidence of Hip Osteoarthritis: Diagnostic Test Study. BMJ. 2015;351:h5983. doi: 10.1136/bmj.h5983
  30. Slayton MH, Baravarian B, Amodei RC, et al. Intense Therapeutic Ultrasound for Pain Relief in the Treatment for Chronic Plantar Fasciopathy. Foot Ankle Orthop. 2019;4(3):1-8. doi: 10.1177/2473011419862228
  31. Zhang Y, Chen T, Luo P, et al. Associations of Dietary Macroelements with Knee Joint Structures, Symptoms, Quality of Life, and Comorbid Conditions in People with Symptomatic Knee Osteoarthritis. Nutrients. 2022;14(17):3576. doi: 10.3390/nu14173576
  32. Dobson F, Hinman RS, Hall M, et al. Measurement Properties of Performance-Based Measures to Assess Physical Function in Hip and Knee Osteoarthritis: A Systematic Review. Osteoarthritis Cartilage. 2012;20(12):1548-62. doi: 10.1016/j.joca.2012.08.015
  33. Whittaker JL, Truong LK, Dhiman K, Beck C. Osteoarthritis Year in Review 2020: Rehabilitation and Outcomes. Osteoarthritis Cartilage. 2021;29(2):190-207. doi: 10.1016/j.joca.2020.10.005
  34. Tubach F, Baron G, Falissard B, et al. Using Patients’ and Rheumatologists’ Opinions to Specify a Short Form of the WOMAC Function Subscale. Ann Rheum Diseas. 2005;64(1):75-9. doi: 10.1136/ard.2003.019539

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