Klotho protein and obstructive sleep apnea: A review

Cover Page

Cite item

Full Text

Abstract

Sleep and Klotho share physiological pathways with the aging process, as both play a significant role in the endocrine and immune systems and, consequently, in the processes of oxidative stress and chronic inflammation, which in turn are the main pathogenetic links of obstructive sleep apnea and Klotho deficiency. Improving the quantity and quality of sleep can be considered a therapeutic approach against aging to prevent, slow down and even reverse physiological decline and degenerative pathologies.

About the authors

Irina M. Madaeva

Scientific Сentre for Family Health and Human Reproduction Problems

Author for correspondence.
Email: nightchild@mail.ru
ORCID iD: 0000-0003-3423-7260

D. Sci. (Med.)

Russian Federation, Irkutsk

Alena A. Pytkina

Scientific Сentre for Family Health and Human Reproduction Problems

Email: nightchild@mail.ru
ORCID iD: 0009-0006-0269-5928

Laboratory research assistant

Russian Federation, Irkutsk

References

  1. Kim B, Kim T, Im H, et al. α-Klotho regulates mouse embryonic neural stem cell proliferation and differentiation. Biochem Biophys Res Commun. 2025;742:151157. doi: 10.1016/j.bbrc.2024.151157
  2. Khan P, Saha N, Nidhi. Neuroprotective effect of naringin by modulation of klotho and HMGB1- TLR4 axis in PTZ-induced kindling in mice. Biochem Biophys Res Commun. 2025;742:151080. doi: 10.1016/j.bbrc.2024.151080
  3. Pavlatou MG, Remaley AT, Gold PW. Klotho: a humeral mediator in CSF and plasma that influences longevity and susceptibility to multiple complex disorders, including depression. Transl Psychiatry. 2016;6(8):e876. doi: 10.1038/tp.2016.135
  4. Rodríguez-Ortiz ME, Jurado-Montoya D, Valdés-Díaz K, et al. Cognitive Impairment Related to Chronic Kidney Disease Is Associated with a Decreased Abundance of Membrane-Bound Klotho in the Cerebral Cortex. Int J Mol Sci. 2024;25(8):4194. doi: 10.3390/ijms25084194
  5. Ge S, Dong F, Tian C, et al. Serum soluble alpha-klotho klotho and cognitive functioning in older adults aged 60 and 79: an analysis of cross-sectional data of the National Health and Nutrition Examination Survey 2011 to 2014. BMC Geriatr. 2024;24(1):245. doi: 10.1186/s12877-024-04661-7
  6. Tang J, Xu Z, Ren L, et al. Association of serum Klotho with the severity and mortality among adults with cardiovascular-kidney-metabolic syndrome. Lipids Health Dis. 2024;23(1):408. doi: 10.1186/s12944-024-02400-w
  7. Veronesi F, Borsari V, Cherubini A, Fini M. Association of Klotho with physical performance and frailty in middle-aged and older adults: A systematic review. Exp Gerontol. 2021;154:111518. doi: 10.1016/j.exger.2021.111518
  8. Martín-Vírgala J, Martín-Carro B, Fernández-Villabrille S, et al. Soluble klotho, a potential biomarker of chronic kidney disease-mineral bone disorders involved in healthy ageing: lights and shadows. Int J Mol Sci. 2024;25(3):1843. doi: 10.3390/ijms25031843
  9. Yamazaki Y, Imura A, Urakawa I, et al. Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects. Biochem Biophys Res Commun. 2010;398(3):513-8. doi: 10.1016/j.bbrc.2010.06.110
  10. Mochón-Benguigui S, Carneiro-Barrera A, Castillo MJ, Amaro-Gahete FJ. Is sleep associated with the s-klotho anti-aging protein in sedentary middle-aged adults? The FIT-AGEING study. Antioxidants (Basel). 2020;9(8):738. doi: 10.3390/antiox9080738
  11. Topal M, Erkus E. Improving sleep quality is essential for enhancing soluble Klotho levels in hemodialysis patients. Int Urol Nephrol. 2023;55(12):3275-320. doi: 10.1007/s11255-023-03693-z
  12. Shin EJ, Chung YH, Le HL, et al. Melatonin attenuates memory impairment induced by Klotho gene deficiency via interactive signaling between MT2 receptor, ERK, and Nrf2-related antioxidant potential. Int J Neuropsychopharmacol. 2014;18(6):pyu105. doi: 10.1093/ijnp/pyu105
  13. Мадаева И.М., Курашова Н.А., Ухинов Э.Б., и др. Изменение относительной длины теломер у пациентов с синдромом обструктивного апноэ сна на фоне СИПАП-терапии: пилотное исследование. Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски. 2022;122(5-2):52-7 [Madaeva IM, Kurashova NA, Ukhinov EB, et al. Changes in the telomeres length in patients with obstructive sleep apnea after continuous positive airway pressure therapy: a pilot study. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(5-2):52-7 (in Russian)]. doi: 10.17116/jnevro202212205252
  14. Pákó J, Kunos L, Mészáros M, et al. Decreased levels of anti-aging klotho in obstructive sleep apnea. Rejuvenation Res. 2020;23(3):256-61. doi: 10.1089/rej.2019.2183
  15. Tempaku PF, D'Almeida V, da Silva SMA, et al. Klotho genetic variants mediate the association between obstructive sleep apnea and short telomere length. Sleep Med. 2021;83:210-1. doi: 10.1016/j.sleep.2021.01.015
  16. Turkiewicz S, Ditmer M, Sochal M, et al. Obstructive sleep apnea as an acceleration trigger of cellular senescence processes through telomere shortening. Int J Mol Sci. 2021;22(22):12536. doi: 10.3390/ijms222212536
  17. Tarnoki AD, Tarnoki DL, Oláh C, et al. Lumbar spine abnormalities in patients with obstructive sleep apnoea. Sci Rep. 2021;11(1):16233. doi: 10.1038/s41598-021-95667-3
  18. Gaspar LS, Álvaro AR, Moita J, Cavadas C. Obstructive sleep apnea and hallmarks of aging. Trends Mol Med. 2017;23(8):675-92. doi: 10.1016/j.molmed.2017.06.006
  19. Madaeva IM, Kurashova NA, Berdina ON, et al. The state of the lPO-AOD system and the relative length of telomeric repeats in the chromosomes of blood leukocytes in obstructive sleep apnea syndrome. Bull Exp Biol Med. 2023;176(1):30-3. doi: 10.1007/s10517-023-05961-5
  20. Madaeva IM, Kurashova NA, Titova EV, et al. Growth Differentiation Factor GDF 15 (“Protein of Senility”) under Conditions of Oxidative Stress and Intermittent Nocturnal Hypoxia in Patients with Sleep Apnea Syndrome. Adv Gerontol. 2024;14(2):61-7. doi: 10.1134/s2079057024600447
  21. Cofta S, Winiarska HM, Płóciniczak A, et al. Oxidative stress markers and severity of obstructive sleep apnea. Adv Exp Med Biol. 2019;1222:27-35. doi: 10.1007/5584_2019_433
  22. Stanek A, Brożyna-Tkaczyk K, Myśliński W. Oxidative stress markers among obstructive sleep apnea patients. Oxid Med Cell Longev. 2021;9681595. doi: 10.1155/2021/9681595
  23. Kunos L, Horvath P, Kis A, et al. Circulating survivin levels in obstructive sleep apnoea. Lung. 2018;196(4):417-24. doi: 10.1007/s00408-018-0120-z
  24. da Paz Oliveira G, Elias RM, Peres Fernandes GB, et al. Decreased concentration of klotho and increased concentration of FGF23 in the cerebrospinal fluid of patients with narcolepsy. Sleep Med. 2021;78:57-62. doi: 10.1016/j.sleep.2020.11.037

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2025 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).