Drug-induced Brugada syndrome: Case report
- Authors: Fedulaev Y.N.1, Makarova I.V.1, Magomedova F.G.1, Arakelov S.E.2,3, Titova I.Y.2
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Affiliations:
- Pirogov Russian National Research Medical University (Pirogov University)
- Demikhov City Clinical Hospital
- Peoples' Friendship University of Russia named after Patrice Lumumba
- Issue: Vol 27, No 10 (2025): Cardiology and nephrology
- Pages: 589-593
- Section: Articles
- URL: https://journals.rcsi.science/2075-1753/article/view/352917
- DOI: https://doi.org/10.26442/20751753.2025.10.203407
- ID: 352917
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Abstract
Brugada syndrome (BrS) is an inherited clinical and electrocardiographic syndrome, related to ion channelopathies and associated with an increased risk of sudden cardiac death. The cornerstone in diagnosis remains a spontaneous type 1 Brugada-pattern on the electrocardiogram (ECG), including J point elevation of ≥ 2 mm, coved-type ST segment elevation and T wave inversion in right precordial leads. Similar ECG changes, induced by antiarrhythmic therapy, should be considered as diagnostic when combined with a documented polymorphic ventricular tachycardia or ventricular fibrillation episode, arrhythmogenic syncope, nocturnal agonal breathing or a family history of sudden cardiac death or BrS. The article represents a clinical case of drug-induced type 1 Brugada-pattern in the settings of antiarrhytmic treatment using 1C class sodium channel blocker ethacizine in a female without additional BrS criteria, with negative genetic testing results and the ECG normalization after drug withdrawal.
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##article.viewOnOriginalSite##About the authors
Yuri N. Fedulaev
Pirogov Russian National Research Medical University (Pirogov University)
Email: irina-makarova93@mail.ru
ORCID iD: 0000-0003-4040-2971
SPIN-code: 2764-7250
Scopus Author ID: 6503940014
ResearcherId: K-7917-2018
D. Sci. (Med.), Prof.
Russian Federation, MoscowIrina V. Makarova
Pirogov Russian National Research Medical University (Pirogov University)
Author for correspondence.
Email: irina-makarova93@mail.ru
ORCID iD: 0000-0001-5127-1300
SPIN-code: 3525-1775
Scopus Author ID: 57211044069
ResearcherId: ABE-1969-2020
Cand. Sci. (Med.)
Russian Federation, MoscowFatima G. Magomedova
Pirogov Russian National Research Medical University (Pirogov University)
Email: irina-makarova93@mail.ru
ORCID iD: 0009-0000-8745-7991
Student
Russian Federation, MoscowSergey E. Arakelov
Demikhov City Clinical Hospital; Peoples' Friendship University of Russia named after Patrice Lumumba
Email: irina-makarova93@mail.ru
ORCID iD: 0000-0003-3911-8543
SPIN-code: 4970-8419
D. Sci. (Med.)
Russian Federation, Moscow; MoscowIrina Yu. Titova
Demikhov City Clinical Hospital
Email: irina-makarova93@mail.ru
ORCID iD: 0000-0001-7056-0634
SPIN-code: 1901-8102
Deputy Chief Doctor
Russian Federation, MoscowReferences
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