Exacerbation of chronic obstructive pulmonary disease: discussion of controversies. A review
- Authors: Zaytsev A.A.1,2
-
Affiliations:
- Burdenko Main Military Clinical Hospital
- BIOTECH University
- Issue: Vol 25, No 9 (2023): Otorhinolaryngology and pulmonology
- Pages: 603-610
- Section: Articles
- URL: https://journals.rcsi.science/2075-1753/article/view/253576
- DOI: https://doi.org/10.26442/20751753.2023.9.202393
- ID: 253576
Cite item
Full Text
Abstract
The paper discusses the controversial issues of infectious exacerbation of chronic obstructive pulmonary disease. Researchers and practitioners share a common understanding of rational patient management, which involves the evolution of exacerbation terminology, the impact of viral infection and air pollutants, the significance of biomarkers, and the appropriate antibiotic therapy regimens. Clinical reflections on the current causes of chronic obstructive pulmonary disease exacerbations and modern therapeutic options are presented.
Full Text
##article.viewOnOriginalSite##About the authors
Andrey A. Zaytsev
Burdenko Main Military Clinical Hospital; BIOTECH University
Author for correspondence.
Email: a-zaicev-a@yandex.ru
ORCID iD: 0000-0002-0934-7313
D. Sci. (Med.), Prof., Burdenko Main Military Clinical Hospital, BIOTECH University
Russian Federation, Moscow; MoscowReferences
- Sadatsafavi M, Xie H, Etminan M, et al; Canadian Respiratory Research Network. The association between previous and future severe exacerbations of chronic obstructive pulmonary disease: Updating the literature using robust statistical methodology. PLoS One. 2018;13(1):e0191243. doi: 10.1371/journal.pone.0191243
- Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2023. Available at: http://www.goldcopd.org/ Accessed: 24.08.2023.
- Клинические рекомендации. Хроническая обструктивная болезнь легких, 2023 (проект) [Klinicheskie rekomendatsii. Khronicheskaia obstruktivnaia bolezn' legkikh, 2023 (proekt) (in Russian)].
- Soriano JB, Alfageme I, Miravitlles M, et al. Prevalencia y determinantes de la EPOC en España: EPISCAN II. Arch Bronconeumol (Engl Ed). 2021;57(1):61-9. doi: 10.1016/j.arbres.2020.07.024
- Lorenz J, Bals R, Dreher M, et al. Expertentreffen COPD. Pneumologie. 2017;71(5):269-89. doi: 10.1055/s-0043-106559
- Rodríguez González-Moro JM, Izquierdo Alonso JL. Oral antibiotic treatment of exacerbation of COPD. Beyond COVID-19. Rev Esp Quimioter. 2021;34(5):429-40. doi: 10.37201/req/125.2021
- MacLeod M, Papi A, Contoli M, et al. Chronic obstructive pulmonary disease exacerbation fundamentals: Diagnosis, treatment, prevention and disease impact. Respirology. 2021;26(6):532-51. doi: 10.1111/resp.14041
- Синопальников А.И., Зайцев А.А. Современный взгляд на фармакотерапию обострений хронической обструктивной болезни легких. Лечащий врач. 2009;10:45-9 [Sinopal'nikov AI, Zaitsev AA. Sovremennyi vzgliad na farmakoterapiiu obostrenii khronicheskoi obstruktivnoi bolezni legkikh. Lechashchii vrach. 2009;10:45-9 (in Russian)].
- Pinto-Plata VM, Livnat G, Girish M, et al. Systemic cytokines, clinical and physiological changes in patients hospitalized for exacerbation of COPD. Chest. 2007;131(1):37-43. doi: 10.1378/chest.06-0668
- Rodriguez-Roisin R. Toward a consensus definition for COPD exacerbations. Chest. 2000;117(5 Suppl. 2):398S-401S. doi: 10.1378/chest.117.5_suppl_2.398s
- Wedzicha JA, Miravitlles M, Hurst JR, et al. Management of COPD exacerbations: a European Respiratory Society/American Thoracic Society guideline. Eur Respir J. 2017;49(3):1600791. doi: 10.1183/13993003.00791-2016
- Anthonisen NR, Manfreda J, Warren CP, et al. Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann Intern Med. 1987;106(2):196-204. doi: 10.7326/0003-4819-106-2-196
- Seemungal T, Harper-Owen R, Bhowmik A, et al. Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001;164(9):1618-23. doi: 10.1164/ajrccm.164.9.2105011
- Celli B, Barnes P. Exacerbations of chronic obstructive pulmonary disease. Eur Respir J. 2007;29(6):1224-38. doi: 10.1183/09031936.00109906
- Paggiaro PL, Dahle R, Bakran I, et al. Multicentre randomised placebo-controlled trial of inhaled fluticasone propionate in patients with chronic obstructive pulmonary disease. International COPD Study Group. Lancet. 1998;351(9105):773-80. doi: 10.1016/s0140-6736(97)03471-5
- Vogelmeier CF, Criner GJ, Martinez FJ, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report: GOLD executive summary. Eur Respir J. 2017;49(3):1700214. doi: 10.1183/13993003.00214-2017
- Miravitlles M, Soler-Cataluña JJ, Calle M, et al. A new approach to grading and treating COPD based on clinical phenotypes: summary of the Spanish COPD guidelines (GesEPOC). Prim Care Respir J. 2013;22(1):117-21. doi: 10.4104/pcrj.2013.00016
- Soler-Cataluña JJ, Martínez-García MA, Román Sánchez P, et al. Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease. Thorax. 2005;60(11):925-31. doi: 10.1136/thx.2005.040527
- Синопальников А.И., Зайцев А.А. Комплаентность пациентов с инфекциями дыхательных путей. Клин микробиол антимикроб химиотер. 2008;10(1):15-23 [Sinopalnikov AI, Zaitsev AA. Patient Compliance with Antimicrobial Therapy of Lower Respiratory Tract Infections. Klin mikrobiol antimikrob khimioter. 2008;10(1):15-23 (in Russian)].
- Peacock JL, Anderson HR, Bremner SA, et al. Outdoor air pollution and respiratory health in patients with COPD. Thorax. 2011;66(7):591-6. doi: 10.1136/thx.2010.155358
- Li J, Sun S, Tang R, et al. Major air pollutants and risk of COPD exacerbations: a systematic review and meta-analysis. Int J Chron Obstruct Pulmon Dis. 2016;11:3079-91. doi: 10.2147/COPD.S122282
- Sethi S. Bacteria in exacerbations of chronic obstructive pulmonary disease: phenomenon or epiphenomenon? Proc Am Thorac Soc. 2004;1(2):109-4. doi: 10.1513/pats.2306029
- González Del Castillo J, Candel FJ, de la Fuente J, et al. Manejo integral del paciente con exacerbación aguda de la enfermedad pulmonary. Rev Esp Quimioter. 2018;31(5):461-84 [González Del Castillo J, Candel FJ, de la Fuente J, et al. Integral approach to the acute exacerbation of chronic obstructive pulmonary disease. Rev Esp Quimioter. 2018;31(5):461-84 (in Spanish)].
- Kherad O, Rutschmann OT. Infections virales à l'origine des exacerbations de la broncho-pneumopathie chronique obstructive. Praxis. 2010;99(4):235-40 [Kherad O, Rutschmann OT. Viral Infections as a Cause of Chronic Obstructive Pulmonary Disease (COPD) Exacerbation. Praxis. 2010;99(4):235-40 (in German)]. doi: 10.1024/1661-8157/a000034
- Murphy TF, Brauer AL, Eschberger K, et al. Pseudomonas aeruginosa in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2008;177(8):853-60. doi: 10.1164/rccm.200709-1413OC
- Gallego M, Pomares X, Espasa M, et al. Pseudomonas aeruginosa isolates in severe chronic obstructive pulmonary disease: Characterization and risk factors. BMC Pulm Med. 2014;14:103. doi: 10.1186/1471-2466-14-103
- Малеев В.В., Зайцев А.А., Яковлев С.В., и др. О применении антибактериальной терапии у пациентов с новой коронавирусной инфекцией COVID-19. Терпевтический архив. 2020;11:4 [Maleev VV, Zaitsev AA, Iakovlev SV, et al. O primenenii antibakterial'noi terapii u patsientov s novoi koronavirusnoi infektsiei COVID-19. Terapevticheskii Arkhiv (Ter. Arkh.). 2020;11:4 (in Russian)].
- Papi A, Bellettato CM, Braccioni F, et al. Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations. Am J Respir Crit Care Med. 2006;173(10):1114-21. doi: 10.1164/rccm.200506-859OC
- Wilkinson TM, Donaldson GC, Johnston SL, et al. Respiratory syncytial virus, airway inflammation, and FEV1 decline in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2006;173(8):871-6. doi: 10.1164/rccm.200509-1489OC
- Зайцев А.А., Синопальников А.И. Рациональная фармакотерапия острых респираторных вирусных инфекций. Consilium Medicum. 2008;10(10):80-6 [Zaytsev AA, Sinopal'nikov AI. Ratsional'naya farmakoterapiya ostrykh respiratornykh virusnykh infektsiy. Consilium Medicum. 2008;10(10):80-6 (in Russian)].
- Mallia P, Footitt J, Sotero R, et al. Rhinovirus infection induces degradation of antimicrobial peptides and secondary bacterial infection in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2012;186(11):1117-24. doi: 10.1164/rccm.201205-0806OC
- Mallia P, Contoli M, Caramori G, et al. Exacerbations of asthma and chronic obstructive pulmonary disease (COPD): focus on virus induced exacerbations. Curr Pharm Des. 2007;13(1):73-97. doi: 10.2174/138161207779313777
- Hurst JR, Donaldson GC, Wilkinson TMA, et al. Epidemiological relationships between the common cold and exacerbation frequency in COPD. Eur Respir J. 2005;26(5):846-52. doi: 10.1183/09031936.05.00043405
- Sethi S, Wrona C, Eschberger K, et al. Inflammatory profile of new bacterial strain exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2008;177(5):491-7. doi: 10.1164/rccm.200708-1234OC
- Stockley RA, O’Brien C, Pye A, Hill S. Relationship of sputum color to nature and outpatient management of acute exacerbations of COPD. Chest. 2000;117(6):1638-45. doi: 10.1378/chest.117.6.1638
- Bafadhel M, McKenna S, Terry S, et al. Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers. Am J Respir Crit Care Med. 2011;184(6):662-71. doi: 10.1164/rccm.201104-0597OC
- Ni W, Bao J, Yang D, et al. Potential of serum procalcitonin in predicting bacterial exacerbation and guiding antibiotic administration in severe COPD exacerbations: a systematic review and meta-analysis. Infect Dis (Lond). 2019;51(9):639-50. doi: 10.1080/23744235.2019.1644456
- Prins HJ, Duijkers R, van der Valk P, et al. CRP-guided antibiotic treatment in acute exacerbations of COPD in hospital admissions. Eur Respir J. 2019;53(5):1802014. doi: 10.1183/13993003.02014-2018
- Jansen WTM, Verel A, Beitsma M, et al. Longitudinal European surveillance study of antibiotic resistance of Haemophilus influenza. J Antimicrob Chemother. 2006;58(4):873-7. doi: 10.1093/jac/dkl310
- Harrison CJ, Woods C, Stout G, et al. Susceptibilities of Haemophilus influenzae, Streptococcus pneumoniae, including serotype 19A, and Moraxella catarrhalis paediatric isolates from 2005 to 2007 to commonly used antibiotics. J Antimicrob Chemother. 2009;63(3):511-9. doi: 10.1093/jac/dkn538
- European Centre for Disease Prevention and Control. Surveillance of antimicrobial resistance in Europe Annual report of the European Antimicrobial Resistance Surveillance Network (EARS-Net) 2017. 2018. doi: 10.2900/230516
- Давыдов А.В., Титов Л.П., Клюйко Н.Л., и др. Чувствительность к антибиотикам штаммов Streptococcus pneumoniae, выделенных от пациентов с пневмонией в Беларуси. Медицинские новости. 2017;12:74-82 [Davydov AV, Titov LP, Klyuiko NL, et al. Antimicrobial susceptibility of Streptococcus pneumoniae strains isolated from patients with pneumonia in Belarus. Meditsinskie novosti. 2017;12:74-82 (in Russian)].
- Куркова А.А., Муравьев А.А., Козлов Р.С. Современное состояние антимикробной резистентности Streptococcus pneumoniae и специфической вакцинопрофилактики пневмококковой инфекции. Пульмонология. 2023;33(4):534-41 [Kurkova AA, Muraviov AA, Kozlov RS. The current status of antimicrobial resistance of Streptococcus pneumoniae and specific vaccine prevention of pneumococcal infection. Pulmonologiya. 2023;33(4):534-41 (in Russian)]. doi: 10.18093/0869-0189-2022-3655
- Vanderkooi OG, Low DE, Green K, et al; Toronto Invasive Bacterial Disease Network. Predicting antimicrobial assistance in invasive pneumococcal infections. Clin Infect Dis. 2005;40(9):1288-97. doi: 10.1086/429242
- Цой А.Н., Сафонова Е.В., Гучев И.А. Цефиксим. Клиническая эффективность при обострении нетяжелой хронической обструктивной болезни легких и влияние на развитие рецидивов заболевания. Лечащий врач. 2011;1:86-90 [Tsoi AN, Safonova EV, Guchev IA. Tsefiksim. Klinicheskaia effektivnost' pri obostrenii netiazheloi khronicheskoi obstruktivnoi bolezni legkikh i vliianie na razvitie retsidivov zabolevaniia. Lechashchii vrach. 2011;1:86-90 (in Russian)].
- Lorenz J, Steinfeld P, Drath L, et al; Cefixime Short-Course versus Standard-Course Study Group. Efficacy and Tolerability of 5- vs 10-Day Cefixime Therapy in Acute Exacerbations of Chronic Bronchitis. Clin Drug Investig. 1998;15(1):13-20. doi: 10.2165/00044011-199815010-00002
- Liu KX, Xu B, Wang J, et al. Efficacy and safety of moxifloxacin in acute exacerbations of chronic bronchitis and COPD: a systematic review and meta-analysis. J Thorac Dis. 2014;6(3):221-9. doi: 10.3978/j.issn.2072-1439.2013.11.12
- Wilson R, Allegra L, Huchon G, et al. MOSAIC Study Group. Short-term and long-term outcomes of moxifloxacin compared to standard antibiotic treatment in acute exacerbations of chronic bronchitis. Chest. 2004;125(3):953-64. doi: 10.1378/chest.125.3.953
- Wilson R, Anzueto A, Miravitlles M, et al. Moxifloxacin versus amoxicillin/clavulanic acid in outpatient acute exacerbations of COPD: MAESTRAL results. Eur Respir J. 2012;40(1):17-27. doi: 10.1183/09031936.00090311
- Chuchalin A, Zakharova M, Dokic D, et al. Efficacy and safety of moxifloxacin in acute exacerbations of chronic bronchitis: a prospective, multicenter, observational study (AVANTI). BMC Pulm Med. 2013;13:5. doi: 10.1186/1471-2466-13-5
- Tulkens P, Arvis P, Kruesmann F. Moxiloxacin Safety An Analysis of 14 Years of Clinical Data. Drugs RD. 2012;12(2):71-100. doi: 10.2165/11634300-000000000-00000
- Van Bambeke F, Tulkens PM. Safety profile of the respiratory fluoroquinolone moxifloxacin: comparison with other fluoroquinolones and other antibacterial classes. Drug Saf. 2009;32(5):359-78. doi: 10.2165/00002018-200932050-00001
- Stass H, Kubitza D, Schühly U. Pharmacokinetics, safety and tolerability of moxifloxacin, a novel 8-methoxyfluoroquinolone, after repeated oral administration. Clin Pharmacokinet. 40(Suppl. 1):1-9. doi: 10.2165/00003088-200140001-00001
- Паценко М.Б., Зайцев А.А., Чернов С.А., и др. Практические подходы к лечению пациентов с новой коронавирусной инфекцией (COVID-19). Военно-медицинский журнал. 2022;343(8):20-7 [Patsenko MB, Zaitsev AA, Chernov SA, et al. Practical approaches to the treatment of patients with new coronavirus infection (COVID-19). Voenno-meditsinskii zhurnal. 2022;343(8):20-7 (in Russian)]. doi: 10.52424/00269050_2022_343_8_20
- Авдеев С.Н., Адамян Л.В., Баранов А.А., и др. Временные методические рекомендации. Профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19). Версия 17. М., 2023 [Avdeev SN, Adamian LV, Baranov AA, et al. Vremennye metodicheskie rekomendatsii. Profilaktika, diagnostika i lechenie novoi koronavirusnoi infektsii (COVID-19). Versiia 17. Moscow, 2023 (in Russian)].
- Зайцев А.А., Клочков О.И., Горелов А.В. Острые респираторные вирусные инфекции: перспективы противовирусной терапии. Вестник семейной медицины. 2009;5:4-10 [Zaitsev AA, Klochkov OI, Gorelov AV. Ostrye respiratornye virusnye infektsii: perspektivy protivovirusnoi terapii. Vestnik semeinoi meditsiny. 2009;5:4-10 (in Russian)].