The state of systolic and diastolic myocardial functions in patients with severe obstructive sleep apnea and their dynamics during CPAP therapy
- Authors: Kuchmin A.N.1, Ekimov V.V.1, Kazachenko A.A.1, Nagornyy M.B.1, Galova E.P.1, Evsyukov K.B.1, Pukhova U.D.1
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Affiliations:
- Kirov Military Medical Academy
- Issue: Vol 25, No 1 (2023): Cardiovascular diseases
- Pages: 52-56
- Section: Articles
- URL: https://journals.rcsi.science/2075-1753/article/view/131644
- DOI: https://doi.org/10.26442/20751753.2023.1.202163
- ID: 131644
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Abstract
Aim. To evaluate the change in the parameters of systolic and diastolic myocardial functions in patients with severe obstructive sleep apnea (OSA) syndrome before and after CPAP therapy.
Materials and methods. Forty eight patients with severe OSA aged 45–74 years were examined. All patients underwent questionnaires, echocardiography with tissue Dopplerography, speckle-tracking echocardiography. At the end of the three-month course of CPAP therapy, the patients were re-examined, followed by a comparative analysis of the data obtained.
Results. In patients with severe OSA after CPAP therapy, the ejection fraction of the left ventricle and the amplitude of systolic displacement of the fibrous ring of the tricuspid valve significantly increased, which indicated an increase in the relative capacity of the ventricular myocardium. The performed CPAP therapy had a positive effect on the diastolic function of the myocardium of both ventricles, which was manifested in an increase in the ratio of peak rates of early and late transmitral and transtricuspidal diastolic flows. The rate of transtricuspidal regurgitation and systolic pressure in the pulmonary artery decreased in dynamics.
Conclusion. The use of CPAP therapy improves systolic and diastolic heart function, leads to a decrease in systolic pressure in the pulmonary artery in patients with severe OSA. The results obtained substantiate the importance of early initiation of CPAP therapy in the complex treatment of patients with OSA.
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##article.viewOnOriginalSite##About the authors
Alexey N. Kuchmin
Kirov Military Medical Academy
Author for correspondence.
Email: kuchmin.63@mail.ru
ORCID iD: 0000-0003-2888-9625
D. Sci. (Med.), Prof.
Russian Federation, Saint PetersburgVitaliy V. Ekimov
Kirov Military Medical Academy
Email: v.ekimov2012@mail.ru
ORCID iD: 0000-0003-3750-4301
Major of Medical Service
Russian Federation, Saint PetersburgAlexandr A. Kazachenko
Kirov Military Medical Academy
Email: kazachenko.alex@gmail.com
ORCID iD: 0000-0002-4578-7893
Cand. Sci. (Med.)
Russian Federation, Saint PetersburgMikhail B. Nagornyy
Kirov Military Medical Academy
Email: ilikedm@mail.ru
ORCID iD: 0000-0002-5542-0948
Cand. Sci. (Med.)
Russian Federation, Saint PetersburgElena P. Galova
Kirov Military Medical Academy
Email: galova.elena@gmail.com
ORCID iD: 0000-0001-7820-0481
Functional Diagnostics Doctor
Russian Federation, Saint PetersburgKonstantin B. Evsyukov
Kirov Military Medical Academy
Email: konsta54@mail.ru
ORCID iD: 0000-0002-7362-7539
Cand. Sci. (Med.)
Russian Federation, Saint PetersburgUliana D. Pukhova
Kirov Military Medical Academy
Email: uliana.dw@gmail.com
ORCID iD: 0000-0002-9952-3981
Clinical Resident
Russian Federation, Saint PetersburgReferences
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