Endocan is a key player in cardiovascular disease: A review

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Abstract

In recent years, the attention of scientists has been actively focused on studying the role of endocan as a biological marker of endothelial dysfunction in cardiovascular diseases. Until recent years, endocan has been studied in acute kidney injury, chronic kidney disease, and renal replacement therapy. Endocan, formerly known as endothelial cell-specific molecule-1, is a soluble dermatan sulfate proteoglycan expressed and secreted into the circulation from endothelial cells. Currently available studies demonstrate the diagnostic and prognostic value of endocan evaluation in cardiovascular pathology. It is expected that further scientific and clinical studies will demonstrate the possibilities of using endocan as an additional laboratory tool for diagnosing and assessing the prognosis in patients with a cardiac profile. Drug regulation of endocan concentration and expression may be a promising target for the treatment of cardiac and vascular pathology.

About the authors

Amina M. Alieva

Pirogov Russian National Research Medical University

Author for correspondence.
Email: amisha_alieva@mail.ru
ORCID iD: 0000-0001-5416-8579
SPIN-code: 2749-6427

Cand. Sci. (Med.)

Russian Federation, Moscow

Elena V. Reznik

Pirogov Russian National Research Medical University

Email: elenaresnik@gmail.com
ORCID iD: 0000-0001-7479-418X
SPIN-code: 3494-9080

D. Sci. (Med.), Prof.

Russian Federation, Moscow

Irina E. Baykova

Pirogov Russian National Research Medical University

Email: 1498553@mail.ru
ORCID iD: 0000-0003-0886-6290
SPIN-code: 3054-8884

Cand. Sci. (Med.)

Russian Federation, Moscow

Natalia V. Teplova

Pirogov Russian National Research Medical University

Email: 1498553@mail.ru
ORCID iD: 0000-0002-7181-4680

D. Sci. (Med.), Prof.

Russian Federation, Moscow

Liudmila M. Makeeva

Pirogov Russian National Research Medical University

Email: mila-mm@yandex.ru
ORCID iD: 0000-0003-0755-4869

Assistant

Russian Federation, Moscow

Kira V. Voronkova

Pirogov Russian National Research Medical University

Email: kiravoronkova@yandex.ru
ORCID iD: 0000-0003-1111-6378
SPIN-code: 1636-7627

D. Sci. (Med.)

Russian Federation, Moscow

Nyurzhanna Kh. Khadzhieva

Central Clinical Hospital “RZD-Medicine”

Email: nurzhanna@yandex.ru
ORCID iD: 0000-0002-5520-281X
SPIN-code: 2520-8520

Cand. Sci. (Med.)

Russian Federation, Moscow

Anna V. Modestova

Pirogov Russian National Research Medical University

Email: a.modestowa@yandex.ru

Cand. Sci. (Med.)

Russian Federation, Moscow

Gaiane G. Totolyan

Pirogov Russian National Research Medical University

Email: tgg03@mail.ru
ORCID iD: 0000-0002-9922-5845

Cand. Sci. (Med.)

Russian Federation, Moscow

Ramiz K. Valiev

Loginov Moscow Clinical Scientific Center

Email: radiosurgery@bk.ru
ORCID iD: 0000-0003-1613-3716

Cand. Sci. (Med.)

Russian Federation, Moscow

Alexander M. Li

MEDSI Group of Companies

Email: steve-sk8@yandex.ru
ORCID iD: 0000-0001-6809-5227

Ultrasound Doctor

Russian Federation, Moscow

Irina A. Kotikova

Pirogov Russian National Research Medical University

Email: kotikova.ia@mail.ru
ORCID iD: 0000-0001-5352-8499

Student

Russian Federation, Moscow

Igor G. Nikitin

Pirogov Russian National Research Medical University

Email: igor.nikitin.64@mail.ru
ORCID iD: 0000-0003-1699-0881

D. Sci. (Med.), Prof.

Russian Federation, Moscow

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