Effectiveness and safety of the herbal preparation Soveren® in patients with hyperuricemia

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Abstract

Background. Despite advances in the field of synthetic pharmaceuticals, interest in the use of natural raw materials from representatives of the flora persists throughout the world. Currently, herbal medicine is successfully used in the treatment of both hyperuricemia (HU) and gout.

Aim. To evaluate the effectiveness and safety of the herbal preparation Soveren® in the prevention and treatment of HU.

Materials and methods. The study included 80 patients who were divided into 2 groups: group 1 consisted of patients diagnosed with arthritis with HU (n=40), group 2 – patients with gout (n=40). The natural complex of natural origin Soveren® was prescribed according to the standard scheme against the background of dietary recommendations. Patients with gout also received urate-lowering therapy. Clinical efficacy and safety of treatment were assessed after 6 and 12 weeks according to the dynamics of laboratory parameters of blood and urine, the EuroQol-5D quality of life questionnaire, assessment of the health status of patients, assessment of patient satisfaction with treatment.

Results. The use of the plant complex Soveren® in patients with HU does not have a negative effect on the functional state of the liver and kidneys. The drug has a significant positive effect on blood levels, reducing uric acid by 1.5 times, creatinine by 1.11 times, and urea by 1.3 times. In group 2, the addition of the Soveren® complex made it possible to achieve the target value of uric acid. In addition, in patients of both groups, within 3 months, the level of total protein in the urine decreased by 3 times, a decrease in the degree of leukocyturia was noted. Against the background of taking the drug in both groups, the relative density of urine increases within the normal range, and a slight acidification of urine was revealed, as well as an increase in urinary excretion of ketones. Most patients positively assessed the result of treatment.

Conclusion. Our data confirm the good therapeutic effect and safety of the herbal complex Soveren® in patients with HU. With the introduction of the Soveren® drug into practice, doctors will have a new effective tool for monitoring the course of HU.

About the authors

Margarita A. Gromova

Pirogov Russian National Research Medical University

Author for correspondence.
Email: margarita-gromov@mail.ru
ORCID iD: 0000-0002-3757-058X

Cand. Sci. (Med.)

Russian Federation, Moscow

Vladimir V. Tsurko

Pirogov Russian National Research Medical University

Email: vvtsurko@mail.ru
ORCID iD: 0000-0001-8040-3704

D. Sci. (Med.)

Russian Federation, Moscow

References

  1. Чазова И.Е., Жернакова Ю.В., Кисляк О.А., и др. Консенсус по ведению пациентов с гиперурикемией и высоким сердечно-сосудистым риском. Системные гипертензии. 2019;16(4):8-21 [Chazova IYe, Zhernakova YuV, Kislyak OA, et al. Consensus on the management of patients with hyperuricemia and high cardiovascular risk. Sistemnyie gipertenzii. 2019;16(4):8-21 (in Russian)]. doi: 10.26442/2075082X.2019.4.190686
  2. Bardin T, Richette P. Definition of hyperuricemia and gouty conditions. Curr Opin Rheumatol. 2014;26(2):186-91. doi: 10.1097/BOR.0000000000000028
  3. Richette P, Doherty M, Pascual E, et al. 2016 updated EULAR evidence-based recommendations for the management of gout. Ann Rheum Dis. 2017;76(1):29-42. doi: 10.1136/annrheumdis-2016-209707
  4. Селимзянова Л.Р., Вишнева Е.А., Федосеенко М.В., Промыслова Е.А. Фитотерапия: современное состояние вопроса. Педиатрическая фармакология. 2016;13(5):488-93 [Selimzyanova LR, Vishneva EA, Fedoseenko MV, Promyslova EA. Phytotherapy: state of health. Pediatricheskaia farmakologiia. 2016;13(5):488-93 (in Russian)]. doi: 10.15690/pf.v13i5.1645
  5. Newman DJ, Cragg GM. Natural products as sources of new drugs from 1981 to 2019. J Nat Prod. 2020;83(3):770-803. doi: 10.1021/acs.jnatprod.9b01285
  6. Михайлова Н.А. Возможности применения фитопрепаратов в терапии гиперурикемии у больных хронической болезнью почек третьей – пятой стадии. Медицинский портал для врачей. Режим доступа: https://umedp.ru/articles/vozmozhnosti_primeneniya_fitopreparatov_v_terapii_giperurikemii_u_bolnykh_khronicheskoy_boleznyu_poch.htm. Ссылка активна на 15.02.2023 [Mikhailova NA. Possibilities of using phytopreparations in the treatment of hyperuricemia in patients with chronic kidney disease of the third-fifth stage. Medical portal for doctors. Available at: https://umedp.ru/articles/vozmozhnosti_primeneniya_fitopreparatov_v_terapii_giperurikemii_u_bolnykh_khronicheskoy_boleznyu_poch.htm. Accessed: 15.02.2023 (in Russian)].
  7. Чабан Н.Г., Путин А.Ю., Рапопорт Л.М., Буслаева Т.М. Фитопрепараты для лечения и профилактики уратного нефролитиаза. Тонкие химические технологии. 2017;12(6):39-45 [Chaban NG, Putin AYu, Rapoport LM, Buslaeva TM. Phytopreparations in the prevention and treatment of urate nephrolithiasis. Tonkiie khimicheskiie tekhnologii. 2017;12(6):39-45 (in Russian)]. doi: 10.32362/2410-6593-2017-12-6-39-45
  8. Corp N, Pendry B. The role of Western herbal medicine in the treatment of gout. Journal of Herbal Medicine. 2013;3(4):157-70. doi: 10.1016/j.hermed.2013.08.002
  9. Yarnell E. Herbs for Gout. Alternative and Complementary Therapies. 2016;22(5):218-25. doi: 10.1089/act.2016.29075.eya
  10. Posadzki P, Watson LK, Ernst E. Adverse effects of herbal medicines: an overview of systematic reviews. Clin Med. 2013;13(1):7-12. doi: 10.7861/clinmedicine.13-1-7
  11. Fatima N, Nayeem N. Toxic Effects as a Result of Herbal Medicine Intake. In book: Toxicology – New Aspects to This Scientific Conundrum, 2016, Ed. 1st. Chapter: 9. doi: 10.5772/64468
  12. Ni Q, Lu X, Chen C, et al. Risk factors for the development of hyperuricemia: A STROBE-compliant cross-sectional and longitudinal study. Medicine (Baltimore). 2019;98(42):e17597. doi: 10.1097/MD.0000000000017597
  13. Cao J, Wang C, Zhang G, et al. Incidence and simple prediction model of Hyperuricemia for urban Han Chinese adults: a prospective cohort study. Int J Environ Res Public Health. 2017;14(1):67. doi: 10.3390/ijerph14010067

Supplementary files

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2. Fig. 1. ROC curve characterizing the dependence of the probability of damage to target organs on the level of uric acid.

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3. Fig. 2. Analysis of the sensitivity and specificity of the model depending on the threshold values of the uric acid level.

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4. Fig. 3. ROC is a curve characterizing the dependence of the probability of a diagnosis of GU on the value of the logistic function P.

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5. Fig. 4. Analysis of the sensitivity and specificity of the model depending on the threshold values of the logistic function P.

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