Rational drug therapy of chronic heart failure: the role of mineralocorticoid receptor antagonists: review

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Abstract

Mineralocorticoid receptor antagonists (MRAs) are part of basic medical therapy for heart failure. The clinical efficacy of MRAs has been proven by randomized clinical trials. To review comparative efficacy and tolerability data between the two main MRAs, spironolactone and eplerenone, in patients with systolic heart failure.

About the authors

Natalia V. Safronova

Chazov National Medical Research Center of Cardiology

Email: izhirov@mail.ru
ORCID iD: 0000-0001-6624-3804

Cand. Sci. (Med.), Chazov National Medical Research Center of Cardiology

Russian Federation, Moscow

Igor V. Zhirov

Chazov National Medical Research Center of Cardiology; Russian Medical Academy of Continuous Professional Education

Author for correspondence.
Email: izhirov@mail.ru
ORCID iD: 0000-0002-4066-2661

D. Sci. (Med.), Chazov National Medical Research Center of Cardiology, Russian Medical Academy of Continuous Professional Education

Russian Federation, Moscow; Moscow

Sergey N. Tereshchenko

Chazov National Medical Research Center of Cardiology; Russian Medical Academy of Continuous Professional Education

Email: tereschenko@yandex.ru
ORCID iD: 0000-0001-9234-6129

D. Sci. (Med.), Prof., Chazov National Medical Research Center of Cardiology, Russian Medical Academy of Continuous Professional Education

Russian Federation, Moscow; Moscow

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