Effect of t-ZrO2-Based Ceramic Samples on the Condition of Muscular and Connecting Tissues in Experimental Animals with Intramuscular Introduction
- Авторы: Kovalko N.Y.1, Kalinina M.V.1, Suslov D.N.2, Galibin O.V.3,4, Yukina G.Y.3, Arsentyev M.Y.1, Shilova O.A.1
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Учреждения:
- Grebenschikov Institute of Silicate Chemistry, Russian Academy of Sciences
- Granov Russian Scientific Center for Radiology and Surgical Technologies, Ministry of Health of the Russian Federation
- Pavlov First Saint Petersburg State Medical University
- Gorbacheva Institute of Pediatric Oncology, Hematology, and Transplantology
- Выпуск: Том 10, № 5 (2019)
- Страницы: 1109-1114
- Раздел: Materials for Ensuring Human Vital Activity and Environmental Protection
- URL: https://journals.rcsi.science/2075-1133/article/view/208080
- DOI: https://doi.org/10.1134/S2075113319050149
- ID: 208080
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Аннотация
A highly dispersed powder (9–10 nm) based on a tetragonal solid solution of partially stabilized zirconia (t-ZrO2) was synthesized by coprecipitation of hydroxides from salt solutions. On the basis of this powder, nanocrystalline ceramic (grain size 60–70 nm) with high physicochemical and mechanical characteristics was obtained: degree of tetragonality c/a, 1.438–1.431; flexural strength, 900–1000 MPa; Vickers hardness, 13–14 GPa; crack resistance, 10–11 MPa m1/2. The ceramic implant obtained was placed into bodies of experimental animals. The response of soft tissues of experimental animals to the introduction of zirconia-based ceramic plates was investigated. The studies showed no toxic effect of the t-ZrO2-based ceramic implant on the tissues surrounding the implant and the organism of laboratory animals in the period from 30 to 195 days from the moment of implantation. The results of in vivo studies suggest that the obtained nanoscale bioceramic can be used in restorative dentistry and endoprosthetics as dental implants, endoprostheses, and bone fragments for transplantology.
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Об авторах
N. Kovalko
Grebenschikov Institute of Silicate Chemistry, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: kovalko.n.yu@gmail.com
Россия, St. Petersburg, 199034
M. Kalinina
Grebenschikov Institute of Silicate Chemistry, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: tikhonov_p-a@mail.ru
Россия, St. Petersburg, 199034
D. Suslov
Granov Russian Scientific Center for Radiology and Surgical Technologies, Ministry of Health of the Russian Federation
Автор, ответственный за переписку.
Email: dn_suslov@rrcrst.ru
Россия, St. Petersburg, 197758
O. Galibin
Pavlov First Saint Petersburg State Medical University; Gorbacheva Institute of Pediatric Oncology, Hematology, and Transplantology
Автор, ответственный за переписку.
Email: ogalibin@mail.ru
Россия, St. Petersburg, 197022; St. Petersburg, 197022
G. Yukina
Pavlov First Saint Petersburg State Medical University
Автор, ответственный за переписку.
Email: pipson@inbox.ru
Россия, St. Petersburg, 197022
M. Arsentyev
Grebenschikov Institute of Silicate Chemistry, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: ars21031960@gmail.com
Россия, St. Petersburg, 199034
O. Shilova
Grebenschikov Institute of Silicate Chemistry, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: olgashilova@bk.ru
Россия, St. Petersburg, 199034
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