Porous Ceramics Based on Substituted Tricalcium Phosphates for Bone Tissue Recovery
- Authors: Fadeeva I.V.1, Fomin A.S.1, Davydova G.A.2, Filippov Y.Y.3, Shaposhnikov M.E.1, Volchenkova V.A.1, Selezneva I.I.2, Barinov S.M.1
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Affiliations:
- Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
- Institute of Mechanics, Moscow State University
- Issue: Vol 10, No 4 (2019)
- Pages: 796-801
- Section: Article
- URL: https://journals.rcsi.science/2075-1133/article/view/207969
- DOI: https://doi.org/10.1134/S2075113319040105
- ID: 207969
Cite item
Abstract
The results of studies concerning ceramics made of substituted (silver, zinc, copper, iron) tricalcium phosphate (TCP) powders are presented. It is shown that the pores in the obtained ceramics are interrelated, the size of macropores ranges from 200 to 400 μm, the size of micropores ranges from 1 to 5 μm, and there are nanopores between the ceramic grains. Such pore sizes can provide the penetration of biological fluxes and cells required for the subsequent formation and growth of new bone tissue into the ceramic matrix. According to the solubility in the physiological solution, the ceramics composed of cation-substituted TCP can be arranged in the following order: Ag ≈ Fe < Cu < Zn. According to the results of studies on the antimicrobial activity with respect to a strain of E. coli bacteria, it has been established that cation-substituted TCPs exhibit a pronounced antimicrobial activity. The highest antimicrobial activity has been shown by the samples of zinc-substituted TCP.
About the authors
I. V. Fadeeva
Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences
Author for correspondence.
Email: fadeeva_inna@mail.ru
Russian Federation, Moscow, 119334
A. S. Fomin
Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences
Email: fadeeva_inna@mail.ru
Russian Federation, Moscow, 119334
G. A. Davydova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: fadeeva_inna@mail.ru
Russian Federation, Pushchino, Moscow oblast, 142290
Ya. Yu. Filippov
Institute of Mechanics, Moscow State University
Email: fadeeva_inna@mail.ru
Russian Federation, Moscow, 119192
M. E. Shaposhnikov
Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences
Email: fadeeva_inna@mail.ru
Russian Federation, Moscow, 119334
V. A. Volchenkova
Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences
Email: fadeeva_inna@mail.ru
Russian Federation, Moscow, 119334
I. I. Selezneva
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: fadeeva_inna@mail.ru
Russian Federation, Pushchino, Moscow oblast, 142290
S. M. Barinov
Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences
Email: fadeeva_inna@mail.ru
Russian Federation, Moscow, 119334