Composite Porous Tubular Biopolymer Matrix of Small Diameter


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One of the main problems in cardiovascular surgery is the lack of functionally reliable small-diameter (no more than 4 mm) vascular grafts required for coronary artery bypass grafting and peripheral artery and vein bypass grafting. The purpose of this work is the development of a composite biopolymer porous tubular matrix (CPTB matrix) 2 and 4 mm in diameter with adjustable resorption time and physicomechanical properties close to native blood vessels of the same diameter. The specimens of CPTB matrices with a diameter of 2 and 4 mm were produced by means of electrospinning from poly(hydroxybutyrate-co-hydroxyvalerate) and gelatin solution in hexafluoroisopropanol. The matrix structure was stabilized by treatment with glutaraldehyde (HA) vapor. It was demonstrated that the best specimen in terms of structure, physicomechanical properties, and resorption rate is the matrix obtained with the ratio of poly(hydroxybutyrate-co-hydroxyvalerate) : gelatin equal to 1 : 2 v/v in the solution and additionally crosslinked in HA vapor for 48 h. The detected slight cytotoxicity of the CBPT matrices developed is easily eliminated by treatment with an aqueous solution containing a set of amino acids. Decreasing the diameter of the substrate rod from 4 to 2 mm is accompanied by small changes in the surface structure and the physicomechanical properties of the CPTB matrix.

作者简介

E. Nemets

Shumakov Federal Research Center of Transplantology and Artificial Organs,
Ministry of Health Care of the Russian Federation

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Email: evgnemets@yandex.ru
俄罗斯联邦, Moscow, 123182

V. Belov

Institute of Biomedical Research and Technologies

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Email: w.000000000@yandex.ru
俄罗斯联邦, Moscow, 123557

T. Ilina

Moscow State University

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Email: ts.iljina@physics.msu.ru
俄罗斯联邦, Moscow, 119991

V. Surguchenko

Shumakov Federal Research Center of Transplantology and Artificial Organs,
Ministry of Health Care of the Russian Federation

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Email: valent.surg@yandex.ru
俄罗斯联邦, Moscow, 123182

A. Pankina

Institute of Biomedical Research and Technologies

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Email: amagniya@yandex.ru
俄罗斯联邦, Moscow, 123557

V. Sevastianov

Shumakov Federal Research Center of Transplantology and Artificial Organs,
Ministry of Health Care of the Russian Federation

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Email: viksev@yandex.ru
俄罗斯联邦, Moscow, 123182

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