Biomedical Materials Based on Polymer-Colloid Dispersion of Succinamide Chitosan-Sol of Silver Iodide

Abstract

Polymer-colloid dispersions which are products of interaction of macromolecules with inorganic sol are of special interest among polymeric materials of biomedical function. The water-soluble sodium salt of chitosan suссinamide (SChT) having a complex of unique properties, among which is biocompatibility with body tissues, bacteriostaticity, ability to biodegradation, and so on, has been used as a basis for creation of film composite materials for biomedical purpose. Sol of silver iodide (AgI) known for its bactericidal properties has been used as colloidal dispersion. Microbiological studies have shown that films on the basis of polymer-colloidal dispersion SChT-AgI possess the expressed bactericidal action, while individual sol and individual SChT at the chosen concentration are characterized only by a bacteriostatic effect. It is revealed that polymer-colloidal dispersion SChT-AgI promotes an increase in resistance of components of blood to action of hemolytic agents. It is established that addition of AgI leads to an increase in tensile strength and decrease in elongation fracture. It is shown that the obtained films in all cases destruct much more slowly and to a lesser extent than an initial film of SChT when maintaining good water-absorbing ability.